ENSMUSG00000008976


Mus musculus

Features
Gene ID: ENSMUSG00000008976
  
Biological name :Gabpa
  
Synonyms : GA-binding protein alpha chain / Gabpa / Q00422
  
Possible biological names infered from orthology : GA binding protein transcription factor alpha subunit / Q06546
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C3.3
Gene start: 84834925
Gene end: 84863779
  
Corresponding Affymetrix probe sets: 10436678 (MoGene1.0st)   1450664_at (Mouse Genome 430 2.0 Array)   1450665_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000009120
Ensembl peptide - ENSMUSP00000109822
NCBI entrez gene - 14390     See in Manteia.
MGI - MGI:95610
RefSeq - XM_017316876
RefSeq - NM_008065
RefSeq - XM_006522907
RefSeq - XM_017316875
RefSeq - XM_006522905
RefSeq - XM_006522906
RefSeq Peptide - NP_032091
swissprot - Q00422
Ensembl - ENSMUSG00000008976
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabpaENSDARG00000069289Danio rerio
 GABPAENSGALG00000015763Gallus gallus
 GABPAENSG00000154727Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ets2 / P15037 / Protein C-ets-2 / P15036* / ETS proto-oncogene 2, transcription factor*ENSMUSG0000002289528
Ets1 / P27577 / Protein C-ets-1 / P14921* / ETS proto-oncogene 1, transcription factor*ENSMUSG0000003203526
Erg / P81270 / Transcriptional regulator ERG / P11308* / ERG, ETS transcription factor*ENSMUSG0000004073225
Fli1 / P26323 / Friend leukemia integration 1 transcription factor / Q01543* / Fli-1 proto-oncogene, ETS transcription factor*ENSMUSG0000001608724
Etv4 / P28322 / ETS translocation variant 4 / P43268* / ETS variant 4*ENSMUSG0000001772419
Etv1 / P41164 / ETS translocation variant 1 / P50549* / ETS variant 1*ENSMUSG0000000415118
Etv2 / P41163 / ETS translocation variant 2 / O00321* / ETS variant 2*ENSMUSG0000000631117
Fev / Q8QZW2 / Protein FEV / Q99581* / FEV, ETS transcription factor*ENSMUSG0000005519716
Etv5 / Q9CXC9 / ETS translocation variant 5 / P41161* / ETS variant 5*ENSMUSG0000001308916
Etv3 / Q8R4Z4 / ETS translocation variant 3 / P41162* / ETS variant 3*ENSMUSG0000000338213
Elk3 / P41971 / ETS domain-containing protein Elk-3 / P41970* / ELK3, ETS transcription factor*ENSMUSG0000000839813
Gm4881 / AC010616.1*ENSMUSG0000010836713
Erf / ETS2 repressor factor / P50548*ENSMUSG0000004085713
Elk1 / P41969 / ETS domain-containing protein Elk-1 / P19419* / ELK1, ETS transcription factor*ENSMUSG0000000940612
Elk4 / P41158 / ETS domain-containing protein Elk-4 / P28324* / ELK4, ETS transcription factor*ENSMUSG0000002643612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR003118  Pointed domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR016312  Transcription factor, GA-binding, alpha subunit
 IPR024668  GA-binding protein alpha subunit, N-terminal
 IPR029071  Ubiquitin-like domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0045653 negative regulation of megakaryocyte differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:1903351 cellular response to dopamine IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Grem1tm1Rmh/Grem1tm1Rmh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Grem1tm1Rmh/Grem1tm1Rmh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Ets1tm1.1Dds/Ets1+
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc32a1tm1Yyan/Slc32a1tm1Yyan
Genetic Background: Not Specified

 MP:0002913 abnormal PNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the peripheral nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ets1tm1.1Dds/Ets1+
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Ets1tm1.1Dds/Ets1+
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0003903 increased cell mass "greater total physical bulk or volume of a cell compared to the normal state" [RGD:Rat Genome Database submission]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tead4tm1Bnno/Tead4tm1Bnno
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ets1tm1.1Dds/Ets1+
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tead4tm1Bnno/Tead4tm1Bnno
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grem1tm1Rmh/Grem1tm1Rmh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004836 abnormal synaptic acetylcholine release "aberrant secretion across synapses of the excitatory neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Ets1tm1.1Dds/Ets1+
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0008057 abnormal DNA replication "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tead4tm1Bnno/Tead4tm1Bnno
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Slc32a1tm1Yyan/Slc32a1tm1Yyan
Genetic Background: Not Specified

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Grem1tm1Rmh/Grem1tm1Rmh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Tead4tm1Bnno/Tead4tm1Bnno
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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