ENSMUSG00000040857


Mus musculus

Features
Gene ID: ENSMUSG00000040857
  
Biological name :Erf
  
Synonyms : Erf / ETS2 repressor factor
  
Possible biological names infered from orthology : P50548
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 25242561
Gene end: 25250761
  
Corresponding Affymetrix probe sets: 10561004 (MoGene1.0st)   1422114_at (Mouse Genome 430 2.0 Array)   1435561_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041912
Ensembl peptide - ENSMUSP00000112046
NCBI entrez gene - 13875     See in Manteia.
MGI - MGI:109637
RefSeq - NM_010155
RefSeq Peptide - NP_034285
swissprot - D3YXK6
swissprot - A0A0R4J0I0
Ensembl - ENSMUSG00000040857
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 erfl1ENSDARG00000086892Danio rerio
 ERFENSG00000105722Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Etv3 / Q8R4Z4 / ETS translocation variant 3 / P41162* / ETS variant 3*ENSMUSG0000000338242
Gm4881 / AC010616.1*ENSMUSG0000010836732
Elk4 / P41158 / ETS domain-containing protein Elk-4 / P28324* / ELK4, ETS transcription factor*ENSMUSG0000002643617
Elk3 / P41971 / ETS domain-containing protein Elk-3 / P41970* / ELK3, ETS transcription factor*ENSMUSG0000000839816
Elk1 / P41969 / ETS domain-containing protein Elk-1 / P19419* / ELK1, ETS transcription factor*ENSMUSG0000000940616
Fli1 / P26323 / Friend leukemia integration 1 transcription factor / Q01543* / Fli-1 proto-oncogene, ETS transcription factor*ENSMUSG0000001608715
Fev / Q8QZW2 / Protein FEV / Q99581* / FEV, ETS transcription factor*ENSMUSG0000005519714
Erg / P81270 / Transcriptional regulator ERG / P11308* / ERG, ETS transcription factor*ENSMUSG0000004073214
Ets1 / P27577 / Protein C-ets-1 / P14921* / ETS proto-oncogene 1, transcription factor*ENSMUSG0000003203512
Etv4 / P28322 / ETS translocation variant 4 / P43268* / ETS variant 4*ENSMUSG0000001772411
Ets2 / P15037 / Protein C-ets-2 / P15036* / ETS proto-oncogene 2, transcription factor*ENSMUSG0000002289511
Etv1 / P41164 / ETS translocation variant 1 / P50549* / ETS variant 1*ENSMUSG0000000415111
Gabpa / Q00422 / GA-binding protein alpha chain / Q06546* / GA binding protein transcription factor alpha subunit*ENSMUSG0000000897611
Etv5 / Q9CXC9 / ETS translocation variant 5 / P41161* / ETS variant 5*ENSMUSG0000001308910
Etv2 / P41163 / ETS translocation variant 2 / O00321* / ETS variant 2*ENSMUSG000000063119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR032925  ETS domain-containing transcription factor ERF
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Oncogene Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Erftm2Gmav/Erftm2.1Gmav
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0000081 premature suture closure "early fusion of the bones of the skull" [J:26513]
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Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Erftm2Gmav/Erftm2.1Gmav
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0000440 domed skull 
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Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Erftm2Gmav/Erftm2.1Gmav
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001711 abnormal placenta 
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nos3tm2.1Plh/Nos3tm2.1Plh
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003403 absent placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005032 abnormal ectoplacental cone 
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009429 decreased embryo weight "reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012090 midbrain hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012099 decreased spongiotrophoblast size "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012134 absent umbilical cord "absence of or failure to form the connective stalk between the fetus and the placenta" [MGI:anna]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012264 hindbrain hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [MGI:anna]
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Allelic Composition: Rag1/Rag2tm1Mnz/Rag1/Rag2tm1Mnz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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