ENSMUSG00000055197


Mus musculus

Features
Gene ID: ENSMUSG00000055197
  
Biological name :Fev
  
Synonyms : Fev / Protein FEV / Q8QZW2
  
Possible biological names infered from orthology : FEV, ETS transcription factor / Q99581
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C4
Gene start: 74881509
Gene end: 74885419
  
Corresponding Affymetrix probe sets: 10355658 (MoGene1.0st)   1425886_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125067
Ensembl peptide - ENSMUSP00000070878
NCBI entrez gene - 260298     See in Manteia.
MGI - MGI:2449712
RefSeq - NM_153111
RefSeq - XM_017320802
RefSeq Peptide - NP_694751
swissprot - E0CXR7
swissprot - Q8QZW2
Ensembl - ENSMUSG00000055197
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FEVENSG00000163497Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fli1 / P26323 / Friend leukemia integration 1 transcription factor / Q01543* / Fli-1 proto-oncogene, ETS transcription factor*ENSMUSG0000001608752
Erg / P81270 / Transcriptional regulator ERG / P11308* / ERG, ETS transcription factor*ENSMUSG0000004073249
Ets1 / P27577 / Protein C-ets-1 / P14921* / ETS proto-oncogene 1, transcription factor*ENSMUSG0000003203533
Erf / ETS2 repressor factor / P50548*ENSMUSG0000004085732
Ets2 / P15037 / Protein C-ets-2 / P15036* / ETS proto-oncogene 2, transcription factor*ENSMUSG0000002289532
Gabpa / Q00422 / GA-binding protein alpha chain / Q06546* / GA binding protein transcription factor alpha subunit*ENSMUSG0000000897631
Etv3 / Q8R4Z4 / ETS translocation variant 3 / P41162* / ETS variant 3*ENSMUSG0000000338231
Etv5 / Q9CXC9 / ETS translocation variant 5 / P41161* / ETS variant 5*ENSMUSG0000001308929
Gm4881 / AC010616.1*ENSMUSG0000010836728
Elk1 / P41969 / ETS domain-containing protein Elk-1 / P19419* / ELK1, ETS transcription factor*ENSMUSG0000000940628
Etv4 / P28322 / ETS translocation variant 4 / P43268* / ETS variant 4*ENSMUSG0000001772428
Elk4 / P41158 / ETS domain-containing protein Elk-4 / P28324* / ELK4, ETS transcription factor*ENSMUSG0000002643627
Elk3 / P41971 / ETS domain-containing protein Elk-3 / P41970* / ELK3, ETS transcription factor*ENSMUSG0000000839827
Etv1 / P41164 / ETS translocation variant 1 / P50549* / ETS variant 1*ENSMUSG0000000415126
Etv2 / P41163 / ETS translocation variant 2 / O00321* / ETS variant 2*ENSMUSG0000000631125


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II NAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042551 neuron maturation IMP
 biological_processGO:0048665 neuron fate specification IMP
 biological_processGO:0051611 regulation of serotonin uptake NAS
 biological_processGO:1905627 regulation of serotonin biosynthetic process NAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0043025 neuronal cell body TAS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000859 abnormal somatosensory cortex morphology "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fevtm1Esd/Fevtm2Esd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Fev-cre)1Esd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Fevtm1Esd/Fevtm2Esd,Tg(Fev-cre/ERT2)aEsd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fevtm1Esd/Fevtm2Esd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Fev-cre)1Esd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fevtm1Esd/Fevtm2Esd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Fev-cre)1Esd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Fevtm1Esd/Fevtm2Esd,Tg(Fev-cre/ERT2)aEsd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003877 abnormal serotonergic neuron morphology "malformation or absence of the neurons that secrete serotonin" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54240]
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Allelic Composition: Cebpatm1Timc/Cebpatm1Timc
Genetic Background: Not Specified

Allelic Composition: Fevtm1Esd/Fevtm1Esd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fevtm1Esd/Fevtm2Esd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Fev-cre)1Esd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fevtm1Esd/Fevtm2Esd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,Tg(Fev-cre)1Esd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Cebpatm1Timc/Cebpatm1Timc
Genetic Background: Not Specified

Allelic Composition: Fevtm1Esd/Fevtm1Esd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

 MP:0010070 decreased serotonin concentration "reduction in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fevtm1Esd/Fevtm2Esd,Tg(Fev-cre/ERT2)aEsd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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