ENSMUSG00000008398


Mus musculus

Features
Gene ID: ENSMUSG00000008398
  
Biological name :Elk3
  
Synonyms : Elk3 / ETS domain-containing protein Elk-3 / P41971
  
Possible biological names infered from orthology : ELK3, ETS transcription factor / P41970
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C2
Gene start: 93247414
Gene end: 93311135
  
Corresponding Affymetrix probe sets: 10371959 (MoGene1.0st)   1417662_at (Mouse Genome 430 2.0 Array)   1435143_at (Mouse Genome 430 2.0 Array)   1445886_at (Mouse Genome 430 2.0 Array)   1448797_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000008542
Ensembl peptide - ENSMUSP00000121754
Ensembl peptide - ENSMUSP00000122324
Ensembl peptide - ENSMUSP00000152060
NCBI entrez gene - 13713     See in Manteia.
MGI - MGI:101762
RefSeq - NM_001282967
RefSeq - NM_001322265
RefSeq - NM_001322268
RefSeq - NM_013508
RefSeq Peptide - NP_001309194
RefSeq Peptide - NP_001269896
RefSeq Peptide - NP_038536
RefSeq Peptide - NP_001309197
swissprot - P41971
swissprot - G3UVX2
swissprot - G3UVW8
Ensembl - ENSMUSG00000008398
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elk3ENSDARG00000018688Danio rerio
 ELK3ENSGALG00000043701Gallus gallus
 ELK3ENSG00000111145Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Elk4 / P41158 / ETS domain-containing protein Elk-4 / P28324* / ELK4, ETS transcription factor*ENSMUSG0000002643649
Elk1 / P41969 / ETS domain-containing protein Elk-1 / P19419* / ELK1, ETS transcription factor*ENSMUSG0000000940639
Erf / ETS2 repressor factor / P50548*ENSMUSG0000004085722
Etv3 / Q8R4Z4 / ETS translocation variant 3 / P41162* / ETS variant 3*ENSMUSG0000000338221
Erg / P81270 / Transcriptional regulator ERG / P11308* / ERG, ETS transcription factor*ENSMUSG0000004073217
Gm4881 / AC010616.1*ENSMUSG0000010836716
Etv4 / P28322 / ETS translocation variant 4 / P43268* / ETS variant 4*ENSMUSG0000001772416
Fli1 / P26323 / Friend leukemia integration 1 transcription factor / Q01543* / Fli-1 proto-oncogene, ETS transcription factor*ENSMUSG0000001608715
Fev / Q8QZW2 / Protein FEV / Q99581* / FEV, ETS transcription factor*ENSMUSG0000005519715
Gabpa / Q00422 / GA-binding protein alpha chain / Q06546* / GA binding protein transcription factor alpha subunit*ENSMUSG0000000897614
Etv1 / P41164 / ETS translocation variant 1 / P50549* / ETS variant 1*ENSMUSG0000000415114
Ets1 / P27577 / Protein C-ets-1 / P14921* / ETS proto-oncogene 1, transcription factor*ENSMUSG0000003203514
Etv5 / Q9CXC9 / ETS translocation variant 5 / P41161* / ETS variant 5*ENSMUSG0000001308914
Ets2 / P15037 / Protein C-ets-2 / P15036* / ETS proto-oncogene 2, transcription factor*ENSMUSG0000002289513
Etv2 / P41163 / ETS translocation variant 2 / O00321* / ETS variant 2*ENSMUSG0000000631111


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0032422 purine-rich negative regulatory element binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcc1tm1Bor/Abcc1tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Abcc1tm1Bor/Abcc1tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abcc1tm1Bor/Abcc1tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Abcc1tm1Bor/Abcc1tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Abcc1tm1Bor/Abcc1tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcc1tm1Bor/Abcc1tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fundc1tm1a(KOMP)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Elk3tm1.2Ics/Elk3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003660 chylothorax "an accumulation of chyle (fluid consisting of lymph and emulsified fats that is formed in the small intestine during digestion of fatty foods and taken up by the lymph vessels) in the thoracic cavity" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:95585]
Show

Allelic Composition: Abcc1tm1Bor/Abcc1tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Elk3tm1.2Ics/Elk3tm1.2Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004038 lymphangiectasis "dilation of the lymphatic vessels, the basic process that may result in the formation of a lymphangioma" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:71816]
Show

Allelic Composition: Abcc1tm1Bor/Abcc1tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Fundc1tm1a(KOMP)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fundc1tm1a(KOMP)Wtsi/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0010097 abnormal retinal blood vessel morphology "any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elk3tm1.2Ics/Elk3tm1.2Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Elk3tm1.2Ics/Elk3+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0010820 abnormal pleura morphology "any structural anomaly of the serous membrane surrounding the lungs and lining the walls of the pleural cavity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Abcc1tm1Bor/Abcc1tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Abcc1tm1Bor/Abcc1tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Elk3tm1.2Ics/Elk3tm1.2Ics
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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