ENSMUSG00000004151


Mus musculus

Features
Gene ID: ENSMUSG00000004151
  
Biological name :Etv1
  
Synonyms : ETS translocation variant 1 / Etv1 / P41164
  
Possible biological names infered from orthology : ETS variant 1 / P50549
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A3
Gene start: 38779380
Gene end: 38870484
  
Corresponding Affymetrix probe sets: 10395457 (MoGene1.0st)   10406934 (MoGene1.0st)   1422607_at (Mouse Genome 430 2.0 Array)   1439906_at (Mouse Genome 430 2.0 Array)   1445314_at (Mouse Genome 430 2.0 Array)   1450684_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124166
Ensembl peptide - ENSMUSP00000124650
Ensembl peptide - ENSMUSP00000125733
Ensembl peptide - ENSMUSP00000125692
Ensembl peptide - ENSMUSP00000125676
Ensembl peptide - ENSMUSP00000125157
Ensembl peptide - ENSMUSP00000124736
Ensembl peptide - ENSMUSP00000124705
Ensembl peptide - ENSMUSP00000093442
Ensembl peptide - ENSMUSP00000124019
NCBI entrez gene - 14009     See in Manteia.
MGI - MGI:99254
RefSeq - NM_007960
RefSeq - XM_006514964
RefSeq - XM_006514965
RefSeq - XM_006514966
RefSeq - XM_006514967
RefSeq - XM_006514968
RefSeq - XM_006514969
RefSeq - XM_006514970
RefSeq - XM_006514971
RefSeq - XM_006514972
RefSeq - NM_001163154
RefSeq Peptide - NP_031986
RefSeq Peptide - NP_001156626
RefSeq Peptide - NP_001334308
swissprot - P41164
swissprot - E0CZ37
swissprot - E0CYN8
swissprot - E0CYI1
swissprot - E0CXX3
swissprot - E0CXE6
swissprot - E0CXD2
swissprot - E0CZ54
swissprot - Q549J8
swissprot - Q8CCR6
Ensembl - ENSMUSG00000004151
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 etv5aENSDARG00000069763Danio rerio
 ETV1ENSGALG00000035504Gallus gallus
 ETV1ENSG00000006468Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Etv5 / Q9CXC9 / ETS translocation variant 5 / P41161* / ETS variant 5*ENSMUSG0000001308962
Etv4 / P28322 / ETS translocation variant 4 / P43268* / ETS variant 4*ENSMUSG0000001772455
Ets2 / P15037 / Protein C-ets-2 / P15036* / ETS proto-oncogene 2, transcription factor*ENSMUSG0000002289521
Ets1 / P27577 / Protein C-ets-1 / P14921* / ETS proto-oncogene 1, transcription factor*ENSMUSG0000003203521
Erg / P81270 / Transcriptional regulator ERG / P11308* / ERG, ETS transcription factor*ENSMUSG0000004073220
Fli1 / P26323 / Friend leukemia integration 1 transcription factor / Q01543* / Fli-1 proto-oncogene, ETS transcription factor*ENSMUSG0000001608718
Gabpa / Q00422 / GA-binding protein alpha chain / Q06546* / GA binding protein transcription factor alpha subunit*ENSMUSG0000000897617
Etv2 / P41163 / ETS translocation variant 2 / O00321* / ETS variant 2*ENSMUSG0000000631114
Elk4 / P41158 / ETS domain-containing protein Elk-4 / P28324* / ELK4, ETS transcription factor*ENSMUSG0000002643613
Fev / Q8QZW2 / Protein FEV / Q99581* / FEV, ETS transcription factor*ENSMUSG0000005519713
Etv3 / Q8R4Z4 / ETS translocation variant 3 / P41162* / ETS variant 3*ENSMUSG0000000338212
Elk1 / P41969 / ETS domain-containing protein Elk-1 / P19419* / ELK1, ETS transcription factor*ENSMUSG0000000940612
Elk3 / P41971 / ETS domain-containing protein Elk-3 / P41970* / ELK3, ETS transcription factor*ENSMUSG0000000839812
Erf / ETS2 repressor factor / P50548*ENSMUSG0000004085712
Gm4881 / AC010616.1*ENSMUSG0000010836712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR006715  PEA3-type ETS-domain transcription factor, N-terminal
 IPR032928  ETS translocation variant 1
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007517 muscle organ development IMP
 biological_processGO:0007638 mechanosensory behavior IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048935 peripheral nervous system neuron development IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000959 abnormal somatic sensory system morphology 
Show

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Etv1tm2Tmj/Etv1+,Etv4tm1Arbr/Etv4+
Genetic Background: involves: 129S1/Sv

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm1Tmj/Etv1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm2Tmj/Etv1+
Genetic Background: involves: 129S1/Sv

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Rnf168Gt(156B6)Cmhd/Rnf168Gt(156B6)Cmhd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Allelic Composition: Etv1tm1Wds/Etv1tm1Wds,Tg(PLAT-cre)116Sdu/0
Genetic Background: Not Specified

Allelic Composition: Etv1tm1Tmj/Etv1tm2Tmj,Tg(EGR3-WGA)1Tmj/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj,Etv4tm1Arbr/Etv4+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj,Ntf3tm2Jae/Ntf3tm2Jae,Tg(PLAT-cre)116Sdu/0
Genetic Background: involves: 129S1/Sv

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

 MP:0000988 abnormal pacinian corpuscle morphology "anomalous structure of any of the rapidly adapting mechanoreceptors found in subcutaneous tissue beneath both hairy and glabrous skin, and which normally contain an afferent nerve fiber surrounded by a capsule with multiple concentric layers" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm1Tmj/Etv1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm2Tmj/Etv1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm2Tmj/Etv1+,Etv4tm1Arbr/Etv4+
Genetic Background: involves: 129S1/Sv

 MP:0000999 abnormal golgi tendon organ morphology "anomalous structure of the sensory organ in muscle that is involved in regulating muscle tension" [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Etv1tm1Tmj/Etv1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm2Tmj/Etv1+
Genetic Background: involves: 129S1/Sv

 MP:0001000 absent golgi tendon organ "missing sensory organ in muscle that is involved in regulating muscle tension" [Principles of Neural Science:ISBN 0-8385-8034-3, J:23882]
Show

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj,Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj,Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
Show

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129S1/Sv

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm2Tmj/Etv1+
Genetic Background: involves: 129S1/Sv

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
Show

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-10H/KitlSl-10H
Genetic Background: involves: 101/H * C3H/HeH

Allelic Composition: Etv1tm1.1(cre/ERT2)Zjh/Etv1tm1.1(cre/ERT2)Zjh
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002578 impaired ability to fire action potentials "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Rnf168Gt(156B6)Cmhd/Rnf168Gt(156B6)Cmhd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129S1/Sv

 MP:0004069 abnormal muscle spindle morphology "anomalous structure of the sensory organs in muscle that are involved in the stretch reflex" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129S1/Sv

 MP:0004297 abnormal proprioceptive neuron morphology "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Etv1tm2Tmj/Etv1tm2Tmj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj,Etv4tm1Arbr/Etv4+
Genetic Background: involves: 129S1/Sv

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zmpste24tm1Otin/Zmpste24tm1Otin
Genetic Background: involves: 129P2/Ola * C57BL/6

 MP:0006006 increased sensory neuron number "greater than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rnf168Gt(156B6)Cmhd/Rnf168Gt(156B6)Cmhd,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0008468 absent muscle spindles "absence of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv1tm2Tmj/Etv1tm2Tmj,Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj,Ntf3tm1Lfr/Ntf3tm1Lfr
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0008485 increased muscle spindle number "greater number of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
Show

Allelic Composition: Etv1tm1Tmj/Etv1+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm2Tmj/Etv1+
Genetic Background: involves: 129S1/Sv

 MP:0008486 decreased muscle spindle number "reduced number of the sensory organs in muscle that are involved in the stretch reflex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
Show

Allelic Composition: Etv1tm1Tmj/Etv1tm2Tmj,Tg(EGR3-WGA)1Tmj/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Etv1tm1Tmj/Etv1tm1Tmj,Etv4tm1Arbr/Etv4+
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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