ENSMUSG00000016087


Mus musculus

Features
Gene ID: ENSMUSG00000016087
  
Biological name :Fli1
  
Synonyms : Fli1 / Friend leukemia integration 1 transcription factor / P26323
  
Possible biological names infered from orthology : Fli-1 proto-oncogene, ETS transcription factor / Q01543
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A4
Gene start: 32422204
Gene end: 32542861
  
Corresponding Affymetrix probe sets: 10592067 (MoGene1.0st)   1422024_at (Mouse Genome 430 2.0 Array)   1433512_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016231
Ensembl peptide - ENSMUSP00000138984
NCBI entrez gene - 14247     See in Manteia.
MGI - MGI:95554
RefSeq - XM_017313133
RefSeq - NM_008026
RefSeq - XM_006510008
RefSeq - XM_006510009
RefSeq Peptide - NP_032052
swissprot - V9GX50
swissprot - P26323
swissprot - Q544B3
Ensembl - ENSMUSG00000016087
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ergENSDARG00000077304Danio rerio
 fli1aENSDARG00000054632Danio rerio
 FLI1ENSGALG00000001161Gallus gallus
 FLI1ENSG00000151702Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Erg / P81270 / Transcriptional regulator ERG / P11308* / ERG, ETS transcription factor*ENSMUSG0000004073267
Ets2 / P15037 / Protein C-ets-2 / P15036* / ETS proto-oncogene 2, transcription factor*ENSMUSG0000002289527
Fev / Q8QZW2 / Protein FEV / Q99581* / FEV, ETS transcription factor*ENSMUSG0000005519727
Ets1 / P27577 / Protein C-ets-1 / P14921* / ETS proto-oncogene 1, transcription factor*ENSMUSG0000003203525
Gabpa / Q00422 / GA-binding protein alpha chain / Q06546* / GA binding protein transcription factor alpha subunit*ENSMUSG0000000897624
Etv5 / Q9CXC9 / ETS translocation variant 5 / P41161* / ETS variant 5*ENSMUSG0000001308920
Etv4 / P28322 / ETS translocation variant 4 / P43268* / ETS variant 4*ENSMUSG0000001772420
Etv1 / P41164 / ETS translocation variant 1 / P50549* / ETS variant 1*ENSMUSG0000000415119
Etv2 / P41163 / ETS translocation variant 2 / O00321* / ETS variant 2*ENSMUSG0000000631119
Erf / ETS2 repressor factor / P50548*ENSMUSG0000004085718
Etv3 / Q8R4Z4 / ETS translocation variant 3 / P41162* / ETS variant 3*ENSMUSG0000000338217
Gm4881 / AC010616.1*ENSMUSG0000010836715
Elk4 / P41158 / ETS domain-containing protein Elk-4 / P28324* / ELK4, ETS transcription factor*ENSMUSG0000002643614
Elk3 / P41971 / ETS domain-containing protein Elk-3 / P41970* / ELK3, ETS transcription factor*ENSMUSG0000000839814
Elk1 / P41969 / ETS domain-containing protein Elk-1 / P19419* / ELK1, ETS transcription factor*ENSMUSG0000000940614


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR003118  Pointed domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR035573  Friend leukemia integration 1 transcription factor, pointed domain
 IPR035575  Friend leukemia integration 1 transcription factor
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008015 blood circulation IMP
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0009987 cellular process TAS
 biological_processGO:0035855 megakaryocyte development IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dapp1Gt(OST111213)Lex/Dapp1Gt(OST111213)Lex
Genetic Background: B6.Cg-Dapp1Gt(OST111213)Lex

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000228 abnormal thrombopoiesis "abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Fli1tm1Morl/Fli1tm1.1Morl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * DBA

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: H2-DMatm1Lkrl/H2-DMatm1Lkrl
Genetic Background: involves: 129P2/OlaHsd

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dapp1Gt(OST111213)Lex/Dapp1Gt(OST111213)Lex
Genetic Background: B6.Cg-Dapp1Gt(OST111213)Lex

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Hps6ru-6J/Hps6ru-6J
Genetic Background: involves: C3H/HeJ

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dapp1Gt(OST111213)Lex/Dapp1Gt(OST111213)Lex
Genetic Background: B6.Cg-Dapp1Gt(OST111213)Lex

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Apctm1Tyj/Apctm1Tyj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Dapp1Gt(OST111213)Lex/Dapp1Gt(OST111213)Lex
Genetic Background: B6.Cg-Dapp1Gt(OST111213)Lex

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Tyj/Apctm1Tyj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hps6ru-6J/Hps6ru-6J
Genetic Background: involves: C3H/HeJ

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apctm1Tyj/Apctm1Tyj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: H2-DMatm1Lkrl/H2-DMatm1Lkrl
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fli1tm2Adh/Fli1tm2Adh
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001917 intraventricular hemorrhage "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Dapp1Gt(OST111213)Lex/Dapp1Gt(OST111213)Lex
Genetic Background: B6.Cg-Dapp1Gt(OST111213)Lex

Allelic Composition: Fli1tm1Ber/Fli1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hps6ru-6J/Hps6ru-6J
Genetic Background: involves: C3H/HeJ

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H2-DMatm1Lkrl/H2-DMatm1Lkrl
Genetic Background: involves: 129P2/OlaHsd

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H2-DMatm1Lkrl/H2-DMatm1Lkrl
Genetic Background: involves: 129P2/OlaHsd

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apctm1Tyj/Apctm1Tyj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Esr1tm1.2Awo/Esr1tm1.2Awo,Kiss1tm1.1(cre)Uboe/Kiss1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Ergmld2/Erg+,Mpltm1Wsa/Mpltm1Wsa
Genetic Background: B6.Cg-Mpltm1Wsa Ergmld2

Allelic Composition: Fli1tm1Morl/Fli1tm1Morl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Fli1tm1Morl/Fli1tm1.1Morl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA * DBA

 MP:0003279 aneurysm "a protruding sac formed by the dilation of the wall of an artery, a vein, or the heart resulting from a weakening of the vessel wall or heart muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Apctm1Tyj/Apctm1Tyj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003719 abnormal pericyte morphology "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Tyj/Apctm1Tyj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004112 abnormal arteriole morphology "structural anomaly in the small diameter vessels that branch from the arteries and lead to the capillaries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apctm1Tyj/Apctm1Tyj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004125 abnormal venule morphology "any structural anomaly in the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apctm1Tyj/Apctm1Tyj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fli1tm1.1Dkw/Fli1tm1.1Dkw
Genetic Background: B6.129S6-Fli1tm1.1Dkw

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hps6ru-6J/Hps6ru-6J
Genetic Background: involves: C3H/HeJ

Allelic Composition: Fli1tm1.1Dkw/Fli1tm1.1Dkw
Genetic Background: B6.129S6-Fli1tm1.1Dkw

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fli1tm1.1Dkw/Fli1tm1.1Dkw
Genetic Background: B6.129S6-Fli1tm1.1Dkw

 MP:0005412 vascular stenosis "narrowing or constriction of a blood vessel" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apctm1Tyj/Apctm1Tyj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apctm1Tyj/Apctm1Tyj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006054 spinal hemorrhage "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0006056 increased vascular endothelial cell number "greater than normal number of cells lining the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Apctm1Tyj/Apctm1Tyj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Fli1tm1Morl/Fli1tm1Morl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fli1tm1.1Dkw/Fli1tm1.1Dkw
Genetic Background: B6.129S6-Fli1tm1.1Dkw

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Fli1tm1.1Dkw/Fli1tm1.1Dkw
Genetic Background: B6.129S6-Fli1tm1.1Dkw

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fli1tm1.1Dkw/Fli1tm1.1Dkw
Genetic Background: B6.129S6-Fli1tm1.1Dkw

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
Show

Allelic Composition: Fli1tm1Morl/Fli1tm1Morl,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Timp3tm1Rkho/Timp3tm1Rkho
Genetic Background: B6.129-Timp3tm1Rkho

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fli1tm1.1Dkw/Fli1tm1.1Dkw
Genetic Background: B6.129S6-Fli1tm1.1Dkw

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fli1tm1.1Dkw/Fli1tm1.1Dkw
Genetic Background: B6.129S6-Fli1tm1.1Dkw

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Fli1tm1.1Dkw/Fli1tm1.1Dkw
Genetic Background: B6.129S6-Fli1tm1.1Dkw

 MP:0009022 abnormal brain meninges morphology "any structural anomaly in any of the membranes covering the brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: H2-DMatm1Lkrl/H2-DMatm1Lkrl
Genetic Background: involves: 129P2/OlaHsd

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Prox1tm3(cre/ERT2)Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Prox1tm3(cre/ERT2)Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: H2-DMatm1Lkrl/H2-DMatm1Lkrl
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fli1tm1Dkw/Fli1tm1Dkw
Genetic Background: either: B6.Cg-Fli1tm1Dkw or (involves: CD-1) or (involves: 129S6/SvEvTac * C57BL/6)

 MP:0020326 dilated capillary "stretched or widened aperture of the luminal space of the small branching blood vessel that form a network between the arterioles and venules" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Apctm1Tyj/Apctm1Tyj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr