ENSMUSG00000032035


Mus musculus

Features
Gene ID: ENSMUSG00000032035
  
Biological name :Ets1
  
Synonyms : Ets1 / P27577 / Protein C-ets-1
  
Possible biological names infered from orthology : ETS proto-oncogene 1, transcription factor / P14921
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A4
Gene start: 32636221
Gene end: 32757820
  
Corresponding Affymetrix probe sets: 10584142 (MoGene1.0st)   1422027_a_at (Mouse Genome 430 2.0 Array)   1422028_a_at (Mouse Genome 430 2.0 Array)   1426725_s_at (Mouse Genome 430 2.0 Array)   1452163_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034534
Ensembl peptide - ENSMUSP00000051303
Ensembl peptide - ENSMUSP00000138951
Ensembl peptide - ENSMUSP00000139107
NCBI entrez gene - 23871     See in Manteia.
MGI - MGI:95455
RefSeq - XM_006510269
RefSeq - NM_001038642
RefSeq - NM_011808
RefSeq Peptide - NP_001033731
RefSeq Peptide - NP_035938
swissprot - P27577
swissprot - Q540Q5
swissprot - V9GX28
swissprot - V9GXE2
swissprot - E9PWI8
Ensembl - ENSMUSG00000032035
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ets2ENSDARG00000103980Danio rerio
 ETS1ENSGALG00000001143Gallus gallus
 ETS1ENSG00000134954Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ets2 / P15037 / Protein C-ets-2 / P15036* / ETS proto-oncogene 2, transcription factor*ENSMUSG0000002289553
Erg / P81270 / Transcriptional regulator ERG / P11308* / ERG, ETS transcription factor*ENSMUSG0000004073227
Gabpa / Q00422 / GA-binding protein alpha chain / Q06546* / GA binding protein transcription factor alpha subunit*ENSMUSG0000000897627
Fli1 / P26323 / Friend leukemia integration 1 transcription factor / Q01543* / Fli-1 proto-oncogene, ETS transcription factor*ENSMUSG0000001608726
Etv4 / P28322 / ETS translocation variant 4 / P43268* / ETS variant 4*ENSMUSG0000001772423
Etv1 / P41164 / ETS translocation variant 1 / P50549* / ETS variant 1*ENSMUSG0000000415123
Etv5 / Q9CXC9 / ETS translocation variant 5 / P41161* / ETS variant 5*ENSMUSG0000001308921
Etv2 / P41163 / ETS translocation variant 2 / O00321* / ETS variant 2*ENSMUSG0000000631119
Fev / Q8QZW2 / Protein FEV / Q99581* / FEV, ETS transcription factor*ENSMUSG0000005519718
Erf / ETS2 repressor factor / P50548*ENSMUSG0000004085715
Gm4881 / AC010616.1*ENSMUSG0000010836714
Etv3 / Q8R4Z4 / ETS translocation variant 3 / P41162* / ETS variant 3*ENSMUSG0000000338214
Elk3 / P41971 / ETS domain-containing protein Elk-3 / P41970* / ELK3, ETS transcription factor*ENSMUSG0000000839813
Elk1 / P41969 / ETS domain-containing protein Elk-1 / P19419* / ELK1, ETS transcription factor*ENSMUSG0000000940613
Elk4 / P41158 / ETS domain-containing protein Elk-4 / P28324* / ELK4, ETS transcription factor*ENSMUSG0000002643612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000418  Ets domain
 IPR003118  Pointed domain
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR016311  Transforming protein C-ets
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II ISO
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009611 response to wounding IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010715 regulation of extracellular matrix disassembly IEA
 biological_processGO:0021854 hypothalamus development IEA
 biological_processGO:0021983 pituitary gland development IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030578 PML body organization IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0034616 response to laminar fluid shear stress IEA
 biological_processGO:0042981 regulation of apoptotic process ISO
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IEA
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045786 negative regulation of cell cycle ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046677 response to antibiotic ISO
 biological_processGO:0048870 cell motility IEA
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0051272 positive regulation of cellular component movement IEA
 biological_processGO:0060055 angiogenesis involved in wound healing IEA
 biological_processGO:0061614 pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:1990837 sequence-specific double-stranded DNA binding IMP


Pathways (from Reactome)
Pathway description
Oncogene Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: FVB.129S-Psaptm1Juma

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: FVB.129S-Psaptm1Juma

 MP:0000370 head blaze "the appearance of a stripe of white fur on the head" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: FVB.129S-Psaptm1Juma

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: FVB.129S-Psaptm1Juma

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: FVB.129S-Psaptm1Juma

Allelic Composition: Ets1tm1.1Dds/Ets1+
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: FVB.129S-Psaptm1Juma

Allelic Composition: Ets1tm1.1Dds/Ets1+
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Gdi1tm1Toni/Y
Genetic Background: B6N.129S7-Gdi1tm1Toni

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gdi1tm1Toni/Y
Genetic Background: B6N.129S7-Gdi1tm1Toni

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: a/a,Mssq6C57BL/6JJcl/?
Genetic Background: involves: C57BL/6JJcl * KK/TaJcl

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gdi1tm1Toni/Y
Genetic Background: B6N.129S7-Gdi1tm1Toni

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: FVB.129S-Psaptm1Juma

 MP:0002369 abnormal thymus subcapsular epithelium morphology "anomalous structure or development of the epithelial cells lining the capsule and trabeculae of the thymus" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: FVB.129S-Psaptm1Juma

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: FVB.129S-Psaptm1Juma

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psaptm1Juma/Psaptm1Juma
Genetic Background: FVB.129S-Psaptm1Juma

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0002938 white spotting "the appearance of patches of white fur" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ets1tm1.1Dds/Ets1tm1.1Dds
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0004955 increased thymus weight "greater than average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ets1tm1.1Dds/Ets1tm1.1Dds
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

Allelic Composition: Ets1tm1.1Dds/Ets1+
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

Allelic Composition: Ets1tm1.1Dds/Ets1tm1.1Dds
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ets1tm1.1Dds/Ets1tm1.1Dds
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

Allelic Composition: Ets1tm1Fwa/Ets1tm1Fwa
Genetic Background: B6.129S4-Ets1tm1Fwa

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: a/a,Mssq6C57BL/6JJcl/?
Genetic Background: involves: C57BL/6JJcl * KK/TaJcl

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * DBA/2J

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ets1tm1.1Dds/Ets1tm1.1Dds
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ets1tm1Fwa/Ets1tm1Fwa
Genetic Background: B6.129S4-Ets1tm1Fwa

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0008050 decreased memory T cell number "reduced number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ets1tm1.1Dds/Ets1tm1.1Dds
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

Allelic Composition: Ets1tm1.1Dds/Ets1+
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ets1tm1.1Dds/Ets1tm1.1Dds
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * DBA/2J

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ets1tm1Fwa/Ets1tm1Fwa
Genetic Background: B6.129S4-Ets1tm1Fwa

 MP:0008203 absent B-1a cells "absence of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Ets1tm1Fwa/Ets1tm1Fwa
Genetic Background: B6.129S4-Ets1tm1Fwa

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ets1tm1Fwa/Ets1tm1Fwa
Genetic Background: B6.129S4-Ets1tm1Fwa

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Ets1tm1Fwa/Ets1tm1Fwa
Genetic Background: B6.129S4-Ets1tm1Fwa

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ets1tm1Fwa/Ets1tm1Fwa
Genetic Background: B6.129S4-Ets1tm1Fwa

 MP:0009322 increased splenocyte apoptosis "increase in the number of spleen cells undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ets1tm1.1Dds/Ets1tm1.1Dds
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

Allelic Composition: Ets1tm1.1Dds/Ets1+
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ets1tm1.1Dds/Ets1tm1.1Dds
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

Allelic Composition: Ets1tm1.1Dds/Ets1+
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

Allelic Composition: Ets1tm1Fwa/Ets1tm1Fwa
Genetic Background: B6.129S4-Ets1tm1Fwa

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

Allelic Composition: Ets1tm1.1Dds/Ets1tm1.1Dds
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ets1tm1.1Dds/Ets1tm1.1Dds
Genetic Background: 129S6/SvEvTac-Ets1tm1.1Dds

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

 MP:0020321 increased vascular endothelial cell apoptosis "increase in the timing or the number of vascular endothelial cells undergoing programmed cell death" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Tg(CD2-Zbtb7b)C8Rbo/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129

Allelic Composition: Ets1tm1Jml/Ets1tm1Jml,Ets2tm5.1Rgo/Ets2tm5.1Rgo,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction






 

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