ENSMUSG00000063065


Mus musculus

Features
Gene ID: ENSMUSG00000063065
  
Biological name :Mapk3
  
Synonyms : Mapk3 / Mitogen-activated protein kinase 3 / Q63844
  
Possible biological names infered from orthology : P27361
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 126759601
Gene end: 126765819
  
Corresponding Affymetrix probe sets: 10557459 (MoGene1.0st)   1427060_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051619
Ensembl peptide - ENSMUSP00000146179
Ensembl peptide - ENSMUSP00000146161
Ensembl peptide - ENSMUSP00000101969
Ensembl peptide - ENSMUSP00000088880
NCBI entrez gene - 26417     See in Manteia.
MGI - MGI:1346859
RefSeq - NM_011952
RefSeq Peptide - NP_036082
swissprot - A0A0U1RPX4
swissprot - D3Z6D8
swissprot - Q63844
swissprot - D3Z3G6
swissprot - A0A0U1RPZ0
Ensembl - ENSMUSG00000063065
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk3ENSDARG00000070573Danio rerio
 MAPK3ENSG00000102882Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*ENSMUSG0000006335881
Mapk7 / Q9WVS8 / Mitogen-activated protein kinase 7 / Q13164*ENSMUSG0000000103449
Nlk / O54949 / Serine/threonine-protein kinase NLK / Q9UBE8* / nemo like kinase*ENSMUSG0000001737640
Mapk6 / Q61532 / Mitogen-activated protein kinase 6 / Q16659*ENSMUSG0000004268839
Mapk4 / Q6P5G0 / Mitogen-activated protein kinase 4 / P31152*ENSMUSG0000002455837
Mapk15 / Q80Y86 / Mitogen-activated protein kinase 15 / Q8TD08*ENSMUSG0000006370437


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008349  Mitogen-activated protein (MAP) kinase, ERK1/2
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002741 positive regulation of cytokine secretion involved in immune response IMP
 biological_processGO:0006351 transcription, DNA-templated IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0006975 DNA damage induced protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009887 animal organ morphogenesis IDA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IMP
 biological_processGO:0014032 neural crest cell development IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0019369 arachidonic acid metabolic process IEA
 biological_processGO:0030278 regulation of ossification IGI
 biological_processGO:0030509 BMP signaling pathway IEA
 biological_processGO:0030641 regulation of cellular pH IMP
 biological_processGO:0030878 thyroid gland development IGI
 biological_processGO:0031281 positive regulation of cyclase activity IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0032872 regulation of stress-activated MAPK cascade TAS
 biological_processGO:0033129 positive regulation of histone phosphorylation IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0035066 positive regulation of histone acetylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IEA
 biological_processGO:0042473 outer ear morphogenesis IGI
 biological_processGO:0043330 response to exogenous dsRNA IDA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048538 thymus development IGI
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0051216 cartilage development IDA
 biological_processGO:0051403 stress-activated MAPK cascade IEA
 biological_processGO:0051493 regulation of cytoskeleton organization TAS
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0060020 Bergmann glial cell differentiation IGI
 biological_processGO:0060324 face development IGI
 biological_processGO:0060425 lung morphogenesis IGI
 biological_processGO:0060440 trachea formation IGI
 biological_processGO:0061308 cardiac neural crest cell development involved in heart development IGI
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 biological_processGO:0070849 response to epidermal growth factor IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IGI
 biological_processGO:0072584 caveolin-mediated endocytosis TAS
 biological_processGO:0090170 regulation of Golgi inheritance TAS
 biological_processGO:1903351 cellular response to dopamine IEA
 biological_processGO:1904355 positive regulation of telomere capping IEA
 biological_processGO:1904417 positive regulation of xenophagy IGI
 biological_processGO:1905050 positive regulation of metallopeptidase activity IMP
 biological_processGO:2000641 regulation of early endosome to late endosome transport TAS
 biological_processGO:2000657 negative regulation of apolipoprotein binding IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005769 early endosome TAS
 cellular_componentGO:0005770 late endosome TAS
 cellular_componentGO:0005794 Golgi apparatus TAS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola TAS
 cellular_componentGO:0005925 focal adhesion TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031143 pseudopodium IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IMP
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0004708 MAP kinase kinase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
MAPK3 (ERK1) activation
RAF-independent MAPK1/3 activation
ISG15 antiviral mechanism
Spry regulation of FGF signaling
Golgi Cisternae Pericentriolar Stack Reorganization
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RNA Polymerase I Promoter Opening
Signal attenuation
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000705 athymia "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Mapk1tm1.1Hed/Mapk1tm1.1Hed,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mapk1tm1.1Hed/Mapk1tm1.1Hed,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001299 abnormal eye distance/ position "abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Grk1tm1Citb/Grk1tm1Citb,Nrltm1Asw/Nrltm1Asw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Grk1tm1Citb/Grk1tm1Citb,Nrltm1Asw/Nrltm1Asw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg,Tg(Myh6-Map2k1*)1Jmol/0
Genetic Background: involves: 129/Sv * FVB/N

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk1tm1Melo/Mapk1+,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N

Allelic Composition: Mapk3tm1Gpg/Mapk3+,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129/Sv * C3H * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grk1tm1Citb/Grk1tm1Citb,Nrltm1Asw/Nrltm1Asw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Krastm1Bbd/Kras+,Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Krastm1Bbd/Kras+,Mapk1tm1.1Hed/Mapk1tm1.1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Mapk1tm1.1Hed/Mapk1tm1.1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129/Sv

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0002798 abnormal active avoidance behavior "defects in the ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002799 abnormal passive avoidance behavior "defects in the ability of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously with prolonged latency" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003808 enlarged endocardial cushions "larger than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [mac:Megan A. Cassell, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk3tm1Gpg/Mapk3+,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129/Sv * C3H * C57BL/6 * FVB/N

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Tg(TcrAND)53Hed/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dll1tm1Mjo/Dll1tm1Mjo,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg,Tg(Cd4-cre)1Cwi/0,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 * SJL

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grk1tm1Citb/Grk1tm1Citb,Nrltm1Asw/Nrltm1Asw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mapk1tm1.1Hed/Mapk1tm1.1Hed,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mapk1tm1.1Hed/Mapk1tm1.1Hed,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Grk1tm1Citb/Grk1tm1Citb,Nrltm1Asw/Nrltm1Asw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005432 abnormal pro-B cell "anomalous structure, development, or number of cells in the developing B cell lineage that have displayed B cell surface markers, but have not yet completed heavy chain gene rearrangement" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005579 absent outer ear "missing auricles or external acoustic meatus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:17694]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0006346 small branchial arch "reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008233 abnormal pro-B cell differentiation "atypical production of or inability to produce the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Malt1m1Btlr/Malt1+
Genetic Background: C57BL/6J-Malt1m1Btlr

 MP:0008716 lung non-small cell carcinoma "a heterogeneous aggregate of at least three distinct histological types of lung cancer" [MESH:C04.557.470.200.300]
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Allelic Composition: Krastm1Bbd/Kras+,Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

 MP:0009905 absent tongue "absence of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0010283 decreased classified tumor incidence "less than the expected number of tumors with a specific classification type in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm1Bbd/Kras+,Mapk1tm1.1Hed/Mapk1tm1.1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Mapk1tm1Melo/Mapk1+,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N

Allelic Composition: Mapk3tm1Gpg/Mapk3+,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129/Sv * C3H * C57BL/6 * FVB/N

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0012269 nuchal edema "abnormal accumulation of subcutaneous fluid in the nuchal region i.e. at the back of the neck" [MGI:anna]
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Allelic Composition: Mapk1tm1Melo/Mapk1+,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N

Allelic Composition: Mapk3tm1Gpg/Mapk3+,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129/Sv * C3H * C57BL/6 * FVB/N

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000003518 Dusp3 / Q9D7X3 / Dual specificity protein phosphatase 3 / P51452* / dual specificity phosphatase 3*  / reaction
 ENSMUSG00000059409 Ppp2r5d / protein phosphatase 2, regulatory subunit B, delta / Q14738* / protein phosphatase 2 regulatory subunit Bdelta*  / reaction
 ENSMUSG00000003541 Ier3 / immediate early response 3 / P46695*  / reaction / complex
 ENSMUSG00000004936 Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*  / complex / reaction
 ENSMUSG00000031383 Dusp9 / dual specificity phosphatase 9 / Q99956*  / reaction
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / complex / reaction
 ENSMUSG00000019960 Dusp6 / Q9DBB1 / Dual specificity protein phosphatase 6 / Q16828* / dual specificity phosphatase 6*  / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / complex / reaction
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / complex / reaction
 ENSMUSG00000031530 Dusp4 / Q8BFV3 / Dual specificity protein phosphatase 4 / Q13115* / dual specificity phosphatase 4*  / reaction
 ENSMUSG00000028062 Q9JHS3 / Lamtor2 / Ragulator complex protein LAMTOR2 / Q9Y2Q5* / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2*  / complex / reaction
 ENSMUSG00000040717 Il17rd / Q8JZL1 / Interleukin-17 receptor D / Q8NFM7*  / complex / reaction
 ENSMUSG00000034765 Dusp5 / dual specificity phosphatase 5 / Q16690*  / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000035027 Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*  / complex / reaction
 ENSMUSG00000005150 Wdr83 / Q9DAJ4 / WD repeat domain containing 83 / Q9BRX9* / WD repeat domain 83*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / reaction
 ENSMUSG00000009406 Elk1 / P41969 / ETS domain-containing protein Elk-1 / P19419* / ELK1, ETS transcription factor*  / reaction
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / reaction
 ENSMUSG00000007411 Mark3 / Q03141 / MAP/microtubule affinity-regulating kinase 3 / P27448* / microtubule affinity regulating kinase 3*  / complex / reaction
 ENSMUSG00000029195 Klb / Q99N32 / Beta-klotho / Q86Z14* / klotho beta*  / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000048376 F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*  / complex / reaction
 ENSMUSG00000056501 Cebpb / P28033 / CCAAT/enhancer-binding protein beta / P17676*  / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / complex / reaction
 ENSMUSG00000031309 P18654 / Rps6ka3 / ribosomal protein S6 kinase polypeptide 3 / P51812* / ribosomal protein S6 kinase A3*  / reaction
 ENSMUSG00000060216 Arrb2 / Q91YI4 / Beta-arrestin-2 / P32121* / arrestin beta 2*  / complex / reaction
 ENSMUSG00000031073 Fgf15 / O35622 / Fibroblast growth factor 15 / FGF19* / O95750* / fibroblast growth factor 19*  / reaction
 ENSMUSG00000000182 Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*  / reaction
 ENSMUSG00000021250 Fos / P01101 / Proto-onco c-Fos / P01100* / Fos proto-oncogene, AP-1 transcription factor subunit*  / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction
 ENSMUSG00000031565 Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*  / reaction
 ENSMUSG00000058488 Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*  / reaction
 ENSMUSG00000003644 P18653 / Rps6ka1 / ribosomal protein S6 kinase polypeptide 1 / Q15418* / ribosomal protein S6 kinase A1*  / reaction
 ENSMUSG00000091512 O88653 / Lamtor3 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 / Q9UHA4*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / reaction
 ENSMUSG00000021180 Q8C050 / Rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / ribosomal protein S6 kinase A5*  / reaction
 ENSMUSG00000022895 Ets2 / P15037 / Protein C-ets-2 / P15036* / ETS proto-oncogene 2, transcription factor*  / reaction
 ENSMUSG00000024777 Q6PD28 / Ppp2r5b / protein phosphatase 2, regulatory subunit B, beta / Q15173* / protein phosphatase 2 regulatory subunit Bbeta*  / reaction / complex
 ENSMUSG00000005320 Fgfr4 / fibroblast growth factor receptor 4 / P22455*  / reaction
 ENSMUSG00000025372 Baiap2 / Q8BKX1 / Brain-specific angiosis inhibitor 1-associated protein 2 / Q9UQB8* / BAI1 associated protein 2*  / reaction
 ENSMUSG00000017843 Q60996 / Ppp2r5c / protein phosphatase 2, regulatory subunit B, gamma / Q13362* / protein phosphatase 2 regulatory subunit Bgamma*  / reaction / complex
 ENSMUSG00000032035 Ets1 / P27577 / Protein C-ets-1 / P14921* / ETS proto-oncogene 1, transcription factor*  / reaction
 ENSMUSG00000018909 Arrb1 / Q8BWG8 / Beta-arrestin-1 / P49407* / arrestin beta 1*  / reaction / complex
 ENSMUSG00000023809 Q9WUT3 / Rps6ka2 / ribosomal protein S6 kinase, polypeptide 2 / Q15349* / ribosomal protein S6 kinase A2*  / reaction
 ENSMUSG00000055980 Irs1 / insulin receptor substrate 1 / P35568*  / reaction
 ENSMUSG00000013698 Pea15a / Q62048 / Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant 4, mRNA. / PEA15* / Q15121* / proliferation and apoptosis adaptor protein 15*  / reaction / complex
 ENSMUSG00000018334 Ksr1 / Q61097 / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA. / Q8IVT5* / kinase suppressor of ras 1*  / complex / reaction
 ENSMUSG00000053716 Dusp7 / Q91Z46 / Dual specificity protein phosphatase 7 / Q16829* / dual specificity phosphatase 7*  / reaction






 

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