ENSMUSG00000013698


Mus musculus

Features
Gene ID: ENSMUSG00000013698
  
Biological name :Pea15a
  
Synonyms : Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant 4, mRNA. / Pea15a / Q62048
  
Possible biological names infered from orthology : PEA15 / proliferation and apoptosis adaptor protein 15 / Q15121
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 172196728
Gene end: 172206804
  
Corresponding Affymetrix probe sets: 10360227 (MoGene1.0st)   1416406_at (Mouse Genome 430 2.0 Array)   1416407_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000013842
Ensembl peptide - ENSMUSP00000106878
Ensembl peptide - ENSMUSP00000117735
NCBI entrez gene - 18611     See in Manteia.
MGI - MGI:104799
RefSeq - XM_017319302
RefSeq - NM_001329871
RefSeq - NM_011063
RefSeq - XM_006496702
RefSeq Peptide - NP_001316800
RefSeq Peptide - NP_035193
RefSeq Peptide - NP_001316798
swissprot - Q62048
swissprot - D3Z375
Ensembl - ENSMUSG00000013698
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pea15ENSDARG00000079771Danio rerio
 PEA15ENSG00000162734Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001875  Death effector domain
 IPR011029  Death-like domain superfamily
 IPR029546  Astrocytic phosphoprotein PEA-15


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0006915 apoptotic process RCA
 biological_processGO:0008643 carbohydrate transport IEA
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0046325 negative regulation of glucose import ISS
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005875 microtubule associated complex NAS
 molecular_functionGO:0005080 protein kinase C binding TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Glra1tm1Rah/Glra1tm1Rah
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Glra1tm1Rah/Glra1tm1Rah
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction / complex
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction / complex






 

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