ENSG00000162734


Homo sapiens

Features
Gene ID: ENSG00000162734
  
Biological name :PEA15
  
Synonyms : PEA15 / proliferation and apoptosis adaptor protein 15 / Q15121
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q23.2
Gene start: 160205337
Gene end: 160215376
  
Corresponding Affymetrix probe sets: 200787_s_at (Human Genome U133 Plus 2.0 Array)   200788_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357055
Ensembl peptide - ENSP00000357056
Ensembl peptide - ENSP00000353660
NCBI entrez gene - 8682     See in Manteia.
OMIM - 603434
RefSeq - XM_006711599
RefSeq - NM_001297576
RefSeq - NM_001297577
RefSeq - NM_001297578
RefSeq - NM_003768
RefSeq Peptide - NP_001284507
RefSeq Peptide - NP_003759
RefSeq Peptide - NP_001284506
RefSeq Peptide - NP_001284505
swissprot - B1AKZ5
swissprot - B1AKZ4
swissprot - Q15121
Ensembl - ENSG00000162734
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pea15ENSDARG00000079771Danio rerio
 Pea15aENSMUSG00000013698Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001875  Death effector domain
 IPR011029  Death-like domain superfamily
 IPR029546  Astrocytic phosphoprotein PEA-15


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008643 carbohydrate transport IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0046325 negative regulation of glucose import IDA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005875 microtubule associated complex NAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
RAF-independent MAPK1/3 activation
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100030 MAPK1 / P28482 / mitogen-activated protein kinase 1  / reaction / complex
 ENSG00000102882 MAPK3 / P27361 / mitogen-activated protein kinase 3  / reaction / complex






 

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