ENSMUSG00000063358


Mus musculus

Features
Gene ID: ENSMUSG00000063358
  
Biological name :Mapk1
  
Synonyms : Mapk1 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P63085
  
Possible biological names infered from orthology : mitogen-activated protein kinase 1 / P28482
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A3
Gene start: 16983382
Gene end: 17047453
  
Corresponding Affymetrix probe sets: 10433940 (MoGene1.0st)   1419568_at (Mouse Genome 430 2.0 Array)   1426585_s_at (Mouse Genome 430 2.0 Array)   1453104_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065983
Ensembl peptide - ENSMUSP00000111396
NCBI entrez gene - 26413     See in Manteia.
MGI - MGI:1346858
RefSeq - XM_006522147
RefSeq - NM_001038663
RefSeq - NM_001357115
RefSeq - NM_011949
RefSeq Peptide - NP_001344044
RefSeq Peptide - NP_036079
RefSeq Peptide - NP_001033752
swissprot - P63085
Ensembl - ENSMUSG00000063358
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk1ENSDARG00000027552Danio rerio
 MAPK1ENSGALG00000001501Gallus gallus
 MAPK1ENSG00000100030Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*ENSMUSG0000006306586
Mapk7 / Q9WVS8 / Mitogen-activated protein kinase 7 / Q13164*ENSMUSG0000000103450
Mapk6 / Q61532 / Mitogen-activated protein kinase 6 / Q16659*ENSMUSG0000004268842
Nlk / O54949 / Serine/threonine-protein kinase NLK / Q9UBE8* / nemo like kinase*ENSMUSG0000001737641
Mapk4 / Q6P5G0 / Mitogen-activated protein kinase 4 / P31152*ENSMUSG0000002455839
Mapk15 / Q80Y86 / Mitogen-activated protein kinase 15 / Q8TD08*ENSMUSG0000006370439


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008349  Mitogen-activated protein (MAP) kinase, ERK1/2
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0006351 transcription, DNA-templated NAS
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009887 animal organ morphogenesis IDA
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0014032 neural crest cell development IGI
 biological_processGO:0015966 diadenosine tetraphosphate biosynthetic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0019858 cytosine metabolic process IDA
 biological_processGO:0030278 regulation of ossification IGI
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030641 regulation of cellular pH IMP
 biological_processGO:0030878 thyroid gland development IGI
 biological_processGO:0031647 regulation of protein stability ISS
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IEA
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0032872 regulation of stress-activated MAPK cascade TAS
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0033598 mammary gland epithelial cell proliferation IDA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038127 ERBB signaling pathway IEA
 biological_processGO:0042473 outer ear morphogenesis IGI
 biological_processGO:0043330 response to exogenous dsRNA IDA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045596 negative regulation of cell differentiation IGI
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048538 thymus development IGI
 biological_processGO:0050852 T cell receptor signaling pathway IDA
 biological_processGO:0050853 B cell receptor signaling pathway IDA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity NAS
 biological_processGO:0051403 stress-activated MAPK cascade IEA
 biological_processGO:0051493 regulation of cytoskeleton organization TAS
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0060020 Bergmann glial cell differentiation IGI
 biological_processGO:0060291 long-term synaptic potentiation IGI
 biological_processGO:0060324 face development IMP
 biological_processGO:0060425 lung morphogenesis IGI
 biological_processGO:0060440 trachea formation IGI
 biological_processGO:0060716 labyrinthine layer blood vessel development IMP
 biological_processGO:0061308 cardiac neural crest cell development involved in heart development IGI
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070849 response to epidermal growth factor IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IGI
 biological_processGO:0072584 caveolin-mediated endocytosis TAS
 biological_processGO:0090170 regulation of Golgi inheritance TAS
 biological_processGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
 biological_processGO:1903351 cellular response to dopamine IEA
 biological_processGO:1904355 positive regulation of telomere capping IEA
 biological_processGO:2000641 regulation of early endosome to late endosome transport TAS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005769 early endosome TAS
 cellular_componentGO:0005770 late endosome TAS
 cellular_componentGO:0005794 Golgi apparatus TAS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola TAS
 cellular_componentGO:0005925 focal adhesion TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031143 pseudopodium IDA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0072686 mitotic spindle ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IMP
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004707 MAP kinase activity IMP
 molecular_functionGO:0004708 MAP kinase kinase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IDA
 molecular_functionGO:0016301 kinase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0031435 mitogen-activated protein kinase kinase kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
phospho-PLA2 pathway
RAF-independent MAPK1/3 activation
MAPK1 (ERK2) activation
Spry regulation of FGF signaling
Golgi Cisternae Pericentriolar Stack Reorganization
ERK/MAPK targets
ERKs are inactivated
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
RSK activation
Signal transduction by L1
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Neutrophil degranulation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signal attenuation
Gastrin-CREB signalling pathway via PKC and MAPK
ESR-mediated signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000087 absent mandible "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Dll3pu-2J/Dll3pu-2J
Genetic Background: B6;CBA-Dll3pu-2J/GrsrJ

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ttc7fsn/Ttc7fsn
Genetic Background: CByJ.A-Ttc7fsn

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: MitfMi/Mitfmi-sp
Genetic Background: B6.Cg-MitfMi/Mitfmi-sp

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000457 maxilla hypoplasia "arrested growth or atrophy of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000705 athymia "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Mapk1tm1.1Hed/Mapk1tm1.1Hed,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mapk1tm1.1Hed/Mapk1tm1.1Hed,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: C57BL/6

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg,Tg(TcraTcrb)1100Mjb/0
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Mapk1tm1.1Kuta/Mapk1tm1.1Kuta
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N

 MP:0001299 abnormal eye distance/ position "abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001353 increased aggression to other mice "when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9]
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Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
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Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Sorl1Gt(Ex255)Byg/Sorl1Gt(Ex255)Byg
Genetic Background: B6.129P2-Sorl1Gt(Ex255)Byg

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Sorl1Gt(Ex255)Byg/Sorl1Gt(Ex255)Byg
Genetic Background: B6.129P2-Sorl1Gt(Ex255)Byg

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Sorl1Gt(Ex255)Byg/Sorl1Gt(Ex255)Byg
Genetic Background: B6.129P2-Sorl1Gt(Ex255)Byg

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: MitfMi/Mitfmi-sp
Genetic Background: B6.Cg-MitfMi/Mitfmi-sp

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mapk3tm1Gpg/Mapk3tm1Gpg,Tg(Myh6-Map2k1*)1Jmol/0
Genetic Background: involves: 129/Sv * FVB/N

Allelic Composition: Mapk1tm1Melo/Mapk1+
Genetic Background: involves: 129S2/SvPas

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: MitfMi/Mitfmi-sp
Genetic Background: B6.Cg-MitfMi/Mitfmi-sp

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Smarca5tm1.1Ais/Smarca5tm1.1Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001705 abnormal proximal-distal axis patterning "anomaly in the formation or development of a body structure, often a limb, in relation to the structure s proximity to the trunk or point of origin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smarca5tm1.1Ais/Smarca5tm1.1Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001717 absent ectoplacental cone 
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Allelic Composition: Smarca5tm1.1Ais/Smarca5tm1.1Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm1Bbd/Kras+,Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Krastm1Bbd/Kras+,Mapk1tm1.1Hed/Mapk1tm1.1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

Allelic Composition: Mapk1tm1.1Hed/Mapk1tm1.1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129/Sv

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smarca5tm1.1Ais/Smarca5tm1.1Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002408 abnormal double-positive T cell "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smarca5tm1.1Ais/Smarca5tm1.1Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002583 absent extraembryonic ectoderm "missing layer of the endoderm of the extraembryonic tissue" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smarca5tm1.1Ais/Smarca5tm1.1Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ath29C57BL/6J/?
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ath29C57BL/6J/?
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ath29C57BL/6J/?
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003808 enlarged endocardial cushions "larger than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [mac:Megan A. Cassell, Mouse Genome Informatics Curator]
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Allelic Composition: MitfMi/Mitfmi-sp
Genetic Background: B6.Cg-MitfMi/Mitfmi-sp

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Prrx1tm1Jfm/Prrx1tm1Jfm
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Mapk1tm1.1Hed/Mapk1tm1.1Hed,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg,Tg(Cd4-cre)1Cwi/0,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 * SJL

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Tg(Lck-cre)1Cwi/0,Tg(TcrAND)53Hed/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0004136 abnormal tongue muscle morphology "anomalous structure or development of the muscular portion of the tongue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prrx1tm1Jfm/Prrx1tm1Jfm
Genetic Background: involves: 129S4/SvJaeSor

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

 MP:0004594 abnormal mandibular coronoid process morphology "any structural anomaly of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion); includes the attachment site to the temporal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

 MP:0004596 abnormal mandibular angle morphology "any structural anomaly of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
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Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Tg(TcrAND)53Hed/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg,Tg(Cd4-cre)1Cwi/0,Tg(TcrAND)53Hed/0
Genetic Background: involves: 129/Sv * C57BL/6 * DBA/2 * SJL

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Tg(Lck-cre)1Cwi/0,Tg(TcrAND)53Hed/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Smarca5tm1.1Ais/Smarca5tm1.1Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mapk1tm1.1Hed/Mapk1tm1.1Hed,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prrx1tm1Jfm/Prrx1tm1Jfm
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mapk1tm1.1Hed/Mapk1tm1.1Hed,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prrx1tm1Jfm/Prrx1tm1Jfm
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ath29C57BL/6J/?
Genetic Background: involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J

Allelic Composition: Mapk1tm1Melo/Mapk1+
Genetic Background: involves: 129S2/SvPas

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smarca5tm1.1Ais/Smarca5tm1.1Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prrx1tm1Jfm/Prrx1tm1Jfm
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005432 abnormal pro-B cell "anomalous structure, development, or number of cells in the developing B cell lineage that have displayed B cell surface markers, but have not yet completed heavy chain gene rearrangement" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005579 absent outer ear "missing auricles or external acoustic meatus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:17694]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0006346 small branchial arch "reduced size of one or more of the branchial arches" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk1tm1.1Hed/Mapk1tm1.1Hed,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk1tm1.1Hed/Mapk1tm1.1Hed,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Mapk1tm1Hed/Mapk1tm1Hed,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008233 abnormal pro-B cell differentiation "atypical production of or inability to produce the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Lmh/Apoetm1Lmh,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008716 lung non-small cell carcinoma "a heterogeneous aggregate of at least three distinct histological types of lung cancer" [MESH:C04.557.470.200.300]
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Allelic Composition: Krastm1Bbd/Kras+,Mapk1tm1.1Hed/Mapk1tm1.1Hed
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc26a4tm1.1Dontu/Slc26a4tm1.1Dontu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

 MP:0009905 absent tongue "absence of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0009907 decreased tongue size "reduced size of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0010283 decreased classified tumor incidence "less than the expected number of tumors with a specific classification type in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm1Bbd/Kras+,Mapk1tm1.1Hed/Mapk1tm1.1Hed,Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: MitfMi/Mitfmi-sp
Genetic Background: B6.Cg-MitfMi/Mitfmi-sp

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Mapk1tm1.1Kuta/Mapk1tm1.1Kuta
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Prrx1tm1Jfm/Prrx1tm1Jfm
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Smarca5tm1.1Ais/Smarca5tm1.1Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

Allelic Composition: Mapk1tm2Moga/Mapk1tm2Moga
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mapk1tm1.1Kuta/Mapk1tm1.1Kuta
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Mapk1tm1Kuta/Mapk1tm1.1Kuta
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Mapk1tm1Melo/Mapk1+,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Smarca5tm1.1Ais/Smarca5tm1.1Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Smarca5tm1.1Ais/Smarca5tm1.1Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0011523 thin placenta labyrinth "decrease in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: Ttc7hea/Ttc7hea
Genetic Background: WBB6F1

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0012056 abnormal polar trophectoderm morphology "any structural anomaly of the trophectoderm portion that surrounds the inner cell mass (ICM); unlike mural trophectoderm cells which stop proliferating and become large polyploid cells (the primary trophoblastic giant cells) by endoreduplication, polar trophectoderm cells remain diploid, continue to proliferate and give rise to both the ectoplacental cone and the extraembryonic ectoderm" [MGI:anna]
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Allelic Composition: Smarca5tm1.1Ais/Smarca5tm1.1Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0012269 nuchal edema "abnormal accumulation of subcutaneous fluid in the nuchal region i.e. at the back of the neck" [MGI:anna]
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Allelic Composition: Mapk1tm1Melo/Mapk1+,Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL/6 * FVB/N

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: ComtB2i/Comt+
Genetic Background: Boulder heterogeneous stock

 MP:0030026 small Meckel s cartilage "reduced size of the cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible and gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [MGI:anna]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

 MP:0030209 abnormal extrinsic tongue muscle morphology "any structural anomaly of any of the four paired muscles that originate outside of and insert into the tongue and act to alter the position of the tongue, allowing for protrusion, retraction, and side-to-side movement; these muscles include the genioglossus, the hyoglossus (often including the chondroglossus), the styloglossus, and the palatoglossus" [https://en.wikipedia.org/wiki/Tongue, https://www.imaios.com/en/e-Anatomy/Anatomical-Parts/Muscles-of-tongue, MGI:anna]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

 MP:0030258 small mandibular condyloid process "reduced size of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint" [MGI:anna]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000002413 Braf / P28028 / Serine/threonine-protein kinase B-raf / P15056* / B-Raf proto-oncogene, serine/threonine kinase*  / complex / reaction
 ENSMUSG00000003518 Dusp3 / Q9D7X3 / Dual specificity protein phosphatase 3 / P51452* / dual specificity phosphatase 3*  / reaction
 ENSMUSG00000059409 Ppp2r5d / protein phosphatase 2, regulatory subunit B, delta / Q14738* / protein phosphatase 2 regulatory subunit Bdelta*  / reaction
 ENSMUSG00000003541 Ier3 / immediate early response 3 / P46695*  / complex / reaction
 ENSMUSG00000004936 Map2k1 / P31938 / Dual specificity mitogen-activated protein kinase kinase 1 / Q02750* / mitogen-activated protein kinase kinase 1*  / complex / reaction
 ENSMUSG00000031383 Dusp9 / dual specificity phosphatase 9 / Q99956*  / reaction
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / complex / reaction
 ENSMUSG00000019960 Dusp6 / Q9DBB1 / Dual specificity protein phosphatase 6 / Q16828* / dual specificity phosphatase 6*  / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / complex / reaction
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / complex / reaction
 ENSMUSG00000031530 Dusp4 / Q8BFV3 / Dual specificity protein phosphatase 4 / Q13115* / dual specificity phosphatase 4*  / reaction
 ENSMUSG00000028062 Q9JHS3 / Lamtor2 / Ragulator complex protein LAMTOR2 / Q9Y2Q5* / late endosomal/lysosomal adaptor, MAPK and MTOR activator 2*  / complex / reaction
 ENSMUSG00000040717 Il17rd / Q8JZL1 / Interleukin-17 receptor D / Q8NFM7*  / complex / reaction
 ENSMUSG00000034765 Dusp5 / dual specificity phosphatase 5 / Q16690*  / reaction
 ENSMUSG00000091512 O88653 / Lamtor3 / late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 / Q9UHA4*  / complex / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / reaction
 ENSMUSG00000009406 Elk1 / P41969 / ETS domain-containing protein Elk-1 / P19419* / ELK1, ETS transcription factor*  / reaction
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / reaction
 ENSMUSG00000056220 P47713 / Pla2g4a / phospholipase A2, group IVA (cytosolic, calcium-dependent) / P47712* / phospholipase A2 group IVA*  / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction / complex
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction
 ENSMUSG00000007411 Mark3 / Q03141 / MAP/microtubule affinity-regulating kinase 3 / P27448* / microtubule affinity regulating kinase 3*  / complex / reaction
 ENSMUSG00000029195 Klb / Q99N32 / Beta-klotho / Q86Z14* / klotho beta*  / reaction
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / reaction / complex
 ENSMUSG00000048376 F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000056501 Cebpb / P28033 / CCAAT/enhancer-binding protein beta / P17676*  / reaction
 ENSMUSG00000022895 Ets2 / P15037 / Protein C-ets-2 / P15036* / ETS proto-oncogene 2, transcription factor*  / reaction
 ENSMUSG00000035152 Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*  / reaction / complex
 ENSMUSG00000060216 Arrb2 / Q91YI4 / Beta-arrestin-2 / P32121* / arrestin beta 2*  / complex / reaction
 ENSMUSG00000031073 Fgf15 / O35622 / Fibroblast growth factor 15 / FGF19* / O95750* / fibroblast growth factor 19*  / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction
 ENSMUSG00000031565 Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*  / reaction
 ENSMUSG00000022841 Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / reaction / complex
 ENSMUSG00000000182 Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*  / reaction
 ENSMUSG00000021250 Fos / P01101 / Proto-onco c-Fos / P01100* / Fos proto-oncogene, AP-1 transcription factor subunit*  / reaction
 ENSMUSG00000035027 Q63932 / Map2k2 / Mus musculus mitogen-activated protein kinase kinase 2 (Map2k2), transcript variant 2, mRNA. / P36507* / AC011005.1* / mitogen-activated protein kinase kinase 2*  / reaction / complex
 ENSMUSG00000003644 P18653 / Rps6ka1 / ribosomal protein S6 kinase polypeptide 1 / Q15418* / ribosomal protein S6 kinase A1*  / reaction
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex / reaction
 ENSMUSG00000031309 P18654 / Rps6ka3 / ribosomal protein S6 kinase polypeptide 3 / P51812* / ribosomal protein S6 kinase A3*  / reaction
 ENSMUSG00000008036 Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*  / complex / reaction
 ENSMUSG00000024777 Q6PD28 / Ppp2r5b / protein phosphatase 2, regulatory subunit B, beta / Q15173* / protein phosphatase 2 regulatory subunit Bbeta*  / reaction / complex
 ENSMUSG00000005320 Fgfr4 / fibroblast growth factor receptor 4 / P22455*  / reaction
 ENSMUSG00000025372 Baiap2 / Q8BKX1 / Brain-specific angiosis inhibitor 1-associated protein 2 / Q9UQB8* / BAI1 associated protein 2*  / reaction
 ENSMUSG00000018909 Arrb1 / Q8BWG8 / Beta-arrestin-1 / P49407* / arrestin beta 1*  / reaction / complex
 ENSMUSG00000023809 Q9WUT3 / Rps6ka2 / ribosomal protein S6 kinase, polypeptide 2 / Q15349* / ribosomal protein S6 kinase A2*  / reaction
 ENSMUSG00000017843 Q60996 / Ppp2r5c / protein phosphatase 2, regulatory subunit B, gamma / Q13362* / protein phosphatase 2 regulatory subunit Bgamma*  / reaction / complex
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / reaction / complex
 ENSMUSG00000032035 Ets1 / P27577 / Protein C-ets-1 / P14921* / ETS proto-oncogene 1, transcription factor*  / reaction
 ENSMUSG00000013698 Pea15a / Q62048 / Mus musculus phosphoprotein enriched in astrocytes 15A (Pea15a), transcript variant 4, mRNA. / PEA15* / Q15121* / proliferation and apoptosis adaptor protein 15*  / reaction / complex
 ENSMUSG00000058488 Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*  / reaction
 ENSMUSG00000018334 Ksr1 / Q61097 / Mus musculus kinase suppressor of ras 1 (Ksr1), transcript variant 2, mRNA. / Q8IVT5* / kinase suppressor of ras 1*  / complex / reaction
 ENSMUSG00000021180 Q8C050 / Rps6ka5 / ribosomal protein S6 kinase, polypeptide 5 / O75582* / ribosomal protein S6 kinase A5*  / reaction
 ENSMUSG00000005150 Wdr83 / Q9DAJ4 / WD repeat domain containing 83 / Q9BRX9* / WD repeat domain 83*  / reaction / complex
 ENSMUSG00000053716 Dusp7 / Q91Z46 / Dual specificity protein phosphatase 7 / Q16829* / dual specificity phosphatase 7*  / reaction






 

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