ENSMUSG00000060216


Mus musculus

Features
Gene ID: ENSMUSG00000060216
  
Biological name :Arrb2
  
Synonyms : Arrb2 / Beta-arrestin-2 / Q91YI4
  
Possible biological names infered from orthology : arrestin beta 2 / P32121
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 70432635
Gene end: 70440828
  
Corresponding Affymetrix probe sets: 10377804 (MoGene1.0st)   1426239_s_at (Mouse Genome 430 2.0 Array)   1451987_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136978
Ensembl peptide - ENSMUSP00000134349
Ensembl peptide - ENSMUSP00000136601
Ensembl peptide - ENSMUSP00000078065
Ensembl peptide - ENSMUSP00000082018
Ensembl peptide - ENSMUSP00000099623
Ensembl peptide - ENSMUSP00000099624
Ensembl peptide - ENSMUSP00000104208
NCBI entrez gene - 216869     See in Manteia.
MGI - MGI:99474
RefSeq - XM_006532917
RefSeq - NM_001271358
RefSeq - NM_001271359
RefSeq - NM_001271360
RefSeq - NM_145429
RefSeq Peptide - NP_663404
RefSeq Peptide - NP_001258287
RefSeq Peptide - NP_001258288
RefSeq Peptide - NP_001258289
swissprot - J3QN53
swissprot - J3QNV6
swissprot - G3UZ54
swissprot - J3JS97
swissprot - Q5F2D9
swissprot - Q91YI4
swissprot - A0A158SIT9
Ensembl - ENSMUSG00000060216
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arrb2aENSDARG00000039215Danio rerio
 arrb2bENSDARG00000011545Danio rerio
 ARRB2ENSG00000141480Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arrb1 / Q8BWG8 / Beta-arrestin-1 / P49407* / arrestin beta 1*ENSMUSG0000001890974
Sag / P20443 / S-antigen, retina and pineal gland (arrestin) / P10523* / S-antigen visual arrestin*ENSMUSG0000005605550
Arr3 / Q9EQP6 / Arrestin-C / P36575* / arrestin 3*ENSMUSG0000006089048


Protein motifs (from Interpro)
Interpro ID Name
 IPR000698  Arrestin
 IPR011021  Arrestin-like, N-terminal
 IPR011022  Arrestin C-terminal-like domain
 IPR014753  Arrestin, N-terminal
 IPR014756  Immunoglobulin E-set
 IPR017864  Arrestin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IGI
 biological_processGO:0001933 negative regulation of protein phosphorylation IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0002031 G-protein coupled receptor internalization ISO
 biological_processGO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin ISO
 biological_processGO:0002092 positive regulation of receptor internalization ISS
 biological_processGO:0006366 transcription by RNA polymerase II ISO
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IMP
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016567 protein ubiquitination ISO
 biological_processGO:0031397 negative regulation of protein ubiquitination ISO
 biological_processGO:0031398 positive regulation of protein ubiquitination ISO
 biological_processGO:0031623 receptor internalization ISO
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0032226 positive regulation of synaptic transmission, dopaminergic IMP
 biological_processGO:0032691 negative regulation of interleukin-1 beta production IMP
 biological_processGO:0032695 negative regulation of interleukin-12 production IMP
 biological_processGO:0032715 negative regulation of interleukin-6 production IMP
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IMP
 biological_processGO:0034260 negative regulation of GTPase activity IEA
 biological_processGO:0034392 negative regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0042699 follicle-stimulating hormone signaling pathway IEA
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0045860 positive regulation of protein kinase activity IC
 biological_processGO:0045953 negative regulation of natural killer cell mediated cytotoxicity ISO
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:0060326 cell chemotaxis ISO
 biological_processGO:0060765 regulation of androgen receptor signaling pathway ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:2000573 positive regulation of DNA biosynthetic process IEA
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030139 endocytic vesicle ISS
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding ISO
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0031691 alpha-1A adrenergic receptor binding IEA
 molecular_functionGO:0031692 alpha-1B adrenergic receptor binding IEA
 molecular_functionGO:0031701 angiotensin receptor binding ISO
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IEA
 molecular_functionGO:0031748 D1 dopamine receptor binding IEA
 molecular_functionGO:0031762 follicle-stimulating hormone receptor binding IEA
 molecular_functionGO:0031826 type 2A serotonin receptor binding IEA
 molecular_functionGO:0031859 platelet activating factor receptor binding IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity ISO
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043422 protein kinase B binding IPI
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IEA
 molecular_functionGO:0071889 14-3-3 protein binding IEA
 molecular_functionGO:1990763 arrestin family protein binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
WNT5A-dependent internalization of FZD4
Activation of SMO
MAP2K and MAPK activation
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Ahrrtm1b(KOMP)Wtsi/Ahrrtm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Ahrrtm1b(KOMP)Wtsi/J

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ahrrtm1b(KOMP)Wtsi/Ahrrtm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Ahrrtm1b(KOMP)Wtsi/J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0001981 enhanced chemically-elicited antinociception "greater than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002274 abnormal type I pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli through which gas exchange occurs; these are thin cells with a large surface area" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ahrrtm1b(KOMP)Wtsi/Ahrrtm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Ahrrtm1b(KOMP)Wtsi/J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Ahrrtm1b(KOMP)Wtsi/Ahrrtm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Ahrrtm1b(KOMP)Wtsi/J

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
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Allelic Composition: Ahrrtm1b(KOMP)Wtsi/Ahrrtm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Ahrrtm1b(KOMP)Wtsi/J

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0008552 abnormal circulating tumor necrosis factor level "anomaly in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008669 increased interleukin-12b secretion "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Neurod2tm1Tap/Neurod2+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ahrrtm1b(KOMP)Wtsi/Ahrrtm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Ahrrtm1b(KOMP)Wtsi/J

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Ahrrtm1b(KOMP)Wtsi/Ahrrtm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Ahrrtm1b(KOMP)Wtsi/J

 MP:0010813 abnormal alveolar lamellar body morphology "any structural anomaly of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0010993 decreased surfactant secretion "decreased production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

 MP:0011148 decreased mesenchymal cell proliferation involved in lung development "reduction in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001761 Smo / P56726 / smoothened, frizzled class receptor / Q99835*  / reaction / complex
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / complex / reaction
 ENSMUSG00000022841 Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / reaction / complex
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex / reaction
 ENSMUSG00000035152 Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*  / complex / reaction
 ENSMUSG00000031390 Avpr2 / O88721 / arginine vasopressin receptor 2 / P30518*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000037727 Avp / P35455 / arginine vasopressin / P01185*  / reaction / complex
 ENSMUSG00000021994 Wnt5a / P22725 / wingless-type MMTV integration site family, member 5A / P41221* / Wnt family member 5A*  / complex / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction / complex
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / complex / reaction
 ENSMUSG00000048376 F2r / P30558 / Proteinase-activated receptor 1 / P25116* / coagulation factor II thrombin receptor*  / reaction / complex
 ENSMUSG00000045730 Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*  / complex / reaction
 ENSMUSG00000018395 Kif3a / P28741 / Kinesin-like protein KIF3A / Q9Y496* / kinesin family member 3A*  / reaction / complex
 ENSMUSG00000049791 Fzd4 / Q61088 / Frizzled-4 / Q9ULV1* / frizzled class receptor 4*  / complex / reaction
 ENSMUSG00000025437 Usp33 / Q8R5K2 / ubiquitin specific peptidase 33 / Q8TEY7*  / complex
 ENSMUSG00000008036 Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*  / complex / reaction
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / reaction / complex
 ENSMUSG00000045613 Chrm2 / Q9ERZ4 / cholinergic receptor, muscarinic 2, cardiac / P08172* / cholinergic receptor muscarinic 2*  / reaction / complex






 

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