ENSMUSG00000025437


Mus musculus

Features
Gene ID: ENSMUSG00000025437
  
Biological name :Usp33
  
Synonyms : Q8R5K2 / ubiquitin specific peptidase 33 / Usp33
  
Possible biological names infered from orthology : Q8TEY7
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: H3
Gene start: 152346478
Gene end: 152393617
  
Corresponding Affymetrix probe sets: 10496919 (MoGene1.0st)   1426709_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117590
Ensembl peptide - ENSMUSP00000143062
Ensembl peptide - ENSMUSP00000142708
Ensembl peptide - ENSMUSP00000026507
Ensembl peptide - ENSMUSP00000113265
NCBI entrez gene - 170822     See in Manteia.
MGI - MGI:2159711
RefSeq - XM_006501079
RefSeq - NM_001076676
RefSeq - NM_001252486
RefSeq - NM_133247
RefSeq Peptide - NP_001239415
RefSeq Peptide - NP_001070144
RefSeq Peptide - NP_573510
swissprot - Q8R5K2
swissprot - A0A0H2UKB8
swissprot - D6RES0
swissprot - A0A0G2JF82
Ensembl - ENSMUSG00000025437
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp33ENSDARG00000016163Danio rerio
 USP33ENSGALG00000008974Gallus gallus
 USP33ENSG00000077254Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usp20 / Q8C6M1 / ubiquitin specific peptidase 20 / Q9Y2K6*ENSMUSG0000002685459
Usp16 / Q99LG0 / ubiquitin specific peptidase 16 / Q9Y5T5*ENSMUSG0000002561617
Usp8 / Q80U87 / ubiquitin specific peptidase 8 / P40818*ENSMUSG0000002736317
Usp2 / O88623 / ubiquitin specific peptidase 2 / O75604*ENSMUSG0000003201016
Usp45 / Q8K387 / ubiquitin specific petidase 45 / Q70EL2* / ubiquitin specific peptidase 45*ENSMUSG0000004045516
Usp21 / ubiquitin specific peptidase 21 / Q9UK80*ENSMUSG0000005348314
Usp50 / Q6P8X6 / ubiquitin specific peptidase 50 / Q70EL3*ENSMUSG0000002736414


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR006615  Peptidase C19, ubiquitin-specific peptidase, DUSP domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain
 IPR035927  DUSP-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0016579 protein deubiquitination ISO
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051298 centrosome duplication IEA
 biological_processGO:0070536 protein K63-linked deubiquitination IEA
 biological_processGO:0071108 protein K48-linked deubiquitination IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017160 Ral GTPase binding IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Regulation of expression of SLITs and ROBOs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022883 Robo1 / roundabout guidance receptor 1 / Q9Y6N7*  / reaction
 ENSMUSG00000033904 Ccp110 / Q7TSH4 / Centriolar coiled-coil protein of 110 kDa / O43303* / centriolar coiled-coil protein 110*  / complex
 ENSMUSG00000045730 Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*  / complex
 ENSMUSG00000060216 Arrb2 / Q91YI4 / Beta-arrestin-2 / P32121* / arrestin beta 2*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr