| MP:0000111 | cleft palate | "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000163 | abnormal cartilage morphology | "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000358 | abnormal cell content/ morphology | "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000562 | polydactyly | "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000822 | abnormal brain ventricle morphology | "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0000925 | abnormal floor plate morphology | "malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0001704 | abnormal dorsal-ventral axis patterning | "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0002151 | abnormal neural tube morphology/development | "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0002633 | persistent truncus arteriosis | "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0003052 | omphalocele | "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0003072 | abnormal metatarsal bone morphology | "anomaly in the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0003077 | abnormal cell cycle | "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Ccp110tm1.2Asw/Ccp110+
Genetic Background: involves: C57BL/6J
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| MP:0004024 | aneuploidy | "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004025 | polyploidy | "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004029 | spontaneous chromosome breakage | "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004200 | reduced fetal size | "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004672 | short ribs | "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004734 | small thoracic cavity | "reduced size of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0004760 | increased mitotic index | "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0005262 | coloboma | "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0005306 | abnormal phalanx morphology | "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0005508 | abnormal skeleton morphology | "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0009743 | preaxial polydactyly | "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0009760 | abnormal mitotic spindle | "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0009882 | absent palatal shelf | "absence of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate" [PMID:16680722] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0010082 | sternebra fusion | "appearance of one or more sternebrae as a single structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0010103 | small thoracic cage | "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0010152 | abnormal brain ependyma morphology | "any structural anomaly of the cellular membrane that lines the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0011056 | abnormal brain ependyma motile cilium morphology | "any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0011065 | abnormal kidney epithelial cell primary cilium morphology | "any structural anomaly of the single non-motile cilium of a kidney epithelial cell that projects into the luminal space of the tubules and ducts where it is thought to act as a flow sensor" [PMID:17995581] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0013202 | abnormal cilium morphology | "any structural anomaly of the specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface; each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole " [GO:0005929] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0013214 | decreased embryonic neuroepithelium primary cilium number | "reduced number of the primary non-motile microtubule-based structures of the embryonic neuroepithelium which are typically short and straight, project apically into the neural tube lumen, and play an essential role in Sonic hedgehog (Shh) signalling and neural tube patterning " [PMID:23351466] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0020137 | decreased bone mineralization | "decrease in the rate at which minerals are deposited into bone" [] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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| MP:0030320 | abnormal temporal bone tympanic part morphology | "any structural anomaly of the curved plate of bone that is situated inferiorly to the squamous part and anteriorly to the mastoid part of the temporal bone; it surrounds the external auditory meatus, forming the anterior wall, floor and some of the posterior wall of the bony external acoustic meatus; its lateral border gives the attachment to the cartilaginous part of the external acoustic meatus; its anteroinferior surface forms the posterior boundary of the mandibular fossa" [https://en.wikipedia.org/wiki/Tympanic_part_of_the_temporal_bone, https://radiopaedia.org/articles/tympanic-part-of-temporal-bone] |
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Allelic Composition: Tg(Tal1-cre/ERT)1Jrg/0,Tsc1tm1Djk/Tsc1tm1Djk
Genetic Background: involves: 129S4/SvJae * C57BL/6
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