ENSMUSG00000045730


Mus musculus

Features
Gene ID: ENSMUSG00000045730
  
Biological name :Adrb2
  
Synonyms : Adrb2 / Beta-2 adrenergic receptor / P18762
  
Possible biological names infered from orthology : adrenoceptor beta 2 / P07550
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: E1
Gene start: 62177817
Gene end: 62179959
  
Corresponding Affymetrix probe sets: 10459288 (MoGene1.0st)   1437302_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062256
NCBI entrez gene - 11555     See in Manteia.
MGI - MGI:87938
RefSeq - NM_007420
RefSeq Peptide - NP_031446
swissprot - P18762
Ensembl - ENSMUSG00000045730
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adrb2aENSDARG00000088124Danio rerio
 adrb2bENSDARG00000054510Danio rerio
 ADRB2ENSGALG00000040035Gallus gallus
 ADRB2ENSG00000169252Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adrb1 / P34971 / Beta-1 adrenergic receptor / P08588* / adrenoceptor beta 1*ENSMUSG0000003528349
Adrb3 / P25962 / Beta-3 adrenergic receptor / P13945* / adrenoceptor beta 3*ENSMUSG0000003148941
Drd1 / Q61616 / D(1A) dopamine receptor / P21728* / dopamine receptor D1*ENSMUSG0000002147830
Drd5 / Q8BLD9 / D(1B) dopamine receptor / P21918* / dopamine receptor D5*ENSMUSG0000003935829
Drd2 / P61168 / D(2) dopamine receptor / P14416* / dopamine receptor D2*ENSMUSG0000003225926
Htr6 / Q9R1C8 / 5-hydroxytryptamine (serotonin) receptor 6 / P50406* / 5-hydroxytryptamine receptor 6*ENSMUSG0000002874726
Htr2b / Q02152 / 5-hydroxytryptamine (serotonin) receptor 2B / P41595* / 5-hydroxytryptamine receptor 2B*ENSMUSG0000002622825
Drd3 / P30728 / D(3) dopamine receptor / P35462* / dopamine receptor D3*ENSMUSG0000002270525
Htr2c / P34968 / 5-hydroxytryptamine (serotonin) receptor 2C / P28335* / 5-hydroxytryptamine receptor 2C*ENSMUSG0000004138025
Hrh2 / P97292 / Histamine H2 receptor / P25021* / histamine receptor H2*ENSMUSG0000003498725
Htr2a / P35363 / 5-hydroxytryptamine (serotonin) receptor 2A / P28223* / 5-hydroxytryptamine receptor 2A*ENSMUSG0000003499723
Drd4 / P51436 / D(4) dopamine receptor / P21917* / dopamine receptor D4*ENSMUSG0000002549622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000332  Beta 2 adrenoceptor
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001993 regulation of systemic arterial blood pressure by norepinephrine-epinephrine IMP
 biological_processGO:0002024 diet induced thermogenesis IGI
 biological_processGO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
 biological_processGO:0002028 regulation of sodium ion transport IMP
 biological_processGO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006940 regulation of smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007190 activation of adenylate cyclase activity IEA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0009409 response to cold IGI
 biological_processGO:0010739 positive regulation of protein kinase A signaling IGI
 biological_processGO:0030501 positive regulation of bone mineralization IMP
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0031649 heat generation IGI
 biological_processGO:0040015 negative regulation of multicellular organism growth IGI
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045453 bone resorption IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0045986 negative regulation of smooth muscle contraction IGI
 biological_processGO:0050873 brown fat cell differentiation IGI
 biological_processGO:0061885 positive regulation of mini excitatory postsynaptic potential IGI
 biological_processGO:0071875 adrenergic receptor signaling pathway IEA
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0097746 regulation of blood vessel diameter IEA
 biological_processGO:1901098 positive regulation of autophagosome maturation IEA
 biological_processGO:1904504 positive regulation of lipophagy IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:2000969 positive regulation of AMPA receptor activity IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IEA
 molecular_functionGO:0004941 beta2-adrenergic receptor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008179 adenylate cyclase binding IDA
 molecular_functionGO:0015459 potassium channel regulator activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0051379 epinephrine binding IBA
 molecular_functionGO:0051380 norepinephrine binding IEA


Pathways (from Reactome)
Pathway description
Adrenoceptors
G alpha (s) signalling events
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Nfkbiatm1.1Kbp/Nfkbiatm1.1Kbp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001629 abnormal heart rate "greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Il3ram1/Il3ram1
Genetic Background: CE/J

Allelic Composition: Adrb2tm1Kry/Adrb2+,Lepob/Lep+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: C57BL/6 * FVB * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il3ram1/Il3ram1
Genetic Background: CE/J

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004945 abnormal bone resorption "anomaly in the process of degrading the organic and inorganic phases of bone by absorption, usually by the abnormal function or by absence of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkbiatm1.1Kbp/Nfkbiatm1.1Kbp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Adrb2tm1Bkk/Adrb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkbiatm1.1Kbp/Nfkbiatm1.1Kbp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkbiatm1.1Kbp/Nfkbiatm1.1Kbp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Adrb2tm1Bkk/Adrb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nfkbiatm1.1Kbp/Nfkbiatm1.1Kbp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0005547 abnormal Muller cell morphology "anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il3ram1/Il3ram1
Genetic Background: CE/J

Allelic Composition: Adrb2tm1Kry/Adrb2+,Lepob/Lep+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: C57BL/6 * FVB * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfkbiatm1.1Kbp/Nfkbiatm1.1Kbp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Adrb2tm1Kry/Adrb2tm1Kry,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfkbiatm1.1Kbp/Nfkbiatm1.1Kbp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Adrb2tm1Bkk/Adrb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0009119 increased brown fat cell size "increase in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0009294 increased interscapular fat pad weight 
Show

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adrb2tm1Bkk/Adrb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
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Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0012107 enhanced exercise endurance "improved performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Gpd2tm1Lbr/Gpd2+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0012143 decreased a wave amplitude "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
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Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Braftm1Cpri/Braf+,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000074886 Grk6 / O70293 / G protein-coupled receptor kinase 6 / P43250*  / complex / reaction
 ENSMUSG00000003228 Grk5 / Q8VEB1 / G protein-coupled receptor kinase 5 / P34947*  / complex / reaction
 ENSMUSG00000024858 Grk2 / Q99MK8 / G protein-coupled receptor kinase 2 / P25098*  / reaction / complex
 ENSMUSG00000018909 Arrb1 / Q8BWG8 / Beta-arrestin-1 / P49407* / arrestin beta 1*  / complex / reaction
 ENSMUSG00000042249 Grk3 / Q3UYH7 / Beta-adrenergic receptor kinase 2 / P35626* / G protein-coupled receptor kinase 3*  / complex / reaction
 ENSMUSG00000026854 Usp20 / Q8C6M1 / ubiquitin specific peptidase 20 / Q9Y2K6*  / complex
 ENSMUSG00000025437 Usp33 / Q8R5K2 / ubiquitin specific peptidase 33 / Q8TEY7*  / complex
 ENSMUSG00000060216 Arrb2 / Q91YI4 / Beta-arrestin-2 / P32121* / arrestin beta 2*  / complex / reaction






 

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