ENSMUSG00000034987


Mus musculus

Features
Gene ID: ENSMUSG00000034987
  
Biological name :Hrh2
  
Synonyms : Histamine H2 receptor / Hrh2 / P97292
  
Possible biological names infered from orthology : histamine receptor H2 / P25021
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B1
Gene start: 54192129
Gene end: 54236180
  
Corresponding Affymetrix probe sets: 10405248 (MoGene1.0st)   1423639_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148117
Ensembl peptide - ENSMUSP00000038170
Ensembl peptide - ENSMUSP00000147413
NCBI entrez gene - 15466     See in Manteia.
MGI - MGI:108482
RefSeq - XM_017315397
RefSeq - NM_001010973
RefSeq - NM_008286
RefSeq - XM_006516852
RefSeq - XM_006516853
RefSeq - XM_006516854
RefSeq Peptide - NP_001010973
RefSeq Peptide - NP_032312
swissprot - A0A1B0GSX9
swissprot - P97292
swissprot - A0A1B0GR79
Ensembl - ENSMUSG00000034987
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hrh2aENSDARG00000107444Danio rerio
 hrh2bENSDARG00000057479Danio rerio
 HRH2ENSGALG00000024171Gallus gallus
 HRH2ENSG00000113749Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Drd5 / Q8BLD9 / D(1B) dopamine receptor / P21918* / dopamine receptor D5*ENSMUSG0000003935833
Adrb1 / P34971 / Beta-1 adrenergic receptor / P08588* / adrenoceptor beta 1*ENSMUSG0000003528330
Drd1 / Q61616 / D(1A) dopamine receptor / P21728* / dopamine receptor D1*ENSMUSG0000002147830
Adrb3 / P25962 / Beta-3 adrenergic receptor / P13945* / adrenoceptor beta 3*ENSMUSG0000003148929
Drd2 / P61168 / D(2) dopamine receptor / P14416* / dopamine receptor D2*ENSMUSG0000003225928
Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*ENSMUSG0000004573027
Htr6 / Q9R1C8 / 5-hydroxytryptamine (serotonin) receptor 6 / P50406* / 5-hydroxytryptamine receptor 6*ENSMUSG0000002874727
Drd3 / P30728 / D(3) dopamine receptor / P35462* / dopamine receptor D3*ENSMUSG0000002270526
Drd4 / P51436 / D(4) dopamine receptor / P21917* / dopamine receptor D4*ENSMUSG0000002549625
Htr2a / P35363 / 5-hydroxytryptamine (serotonin) receptor 2A / P28223* / 5-hydroxytryptamine receptor 2A*ENSMUSG0000003499725
Htr2c / P34968 / 5-hydroxytryptamine (serotonin) receptor 2C / P28335* / 5-hydroxytryptamine receptor 2C*ENSMUSG0000004138023
Htr2b / Q02152 / 5-hydroxytryptamine (serotonin) receptor 2B / P41595* / 5-hydroxytryptamine receptor 2B*ENSMUSG0000002622823


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000503  Histamine H2 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001696 gastric acid secretion IEA
 biological_processGO:0001697 histamine-induced gastric acid secretion IMP
 biological_processGO:0001698 gastrin-induced gastric acid secretion IMP
 biological_processGO:0003382 epithelial cell morphogenesis IMP
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007613 memory IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0048167 regulation of synaptic plasticity IMP
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0048732 gland development IMP
 biological_processGO:1901998 toxin transport IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004969 histamine receptor activity IEA


Pathways (from Reactome)
Pathway description
Histamine receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000505 reduced digestive secretion "decrease in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001650 electrically induced seizures "high or low frequency electrical stimulation applied to induce seizure activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
Show

Allelic Composition: Gsdmetm1Ant/Gsdmetm1Ant,Pjvktm1Ugds/Pjvktm1Ugds
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * CBA/Ca

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gsdmetm1Ant/Gsdmetm1Ant,Pjvktm1Ugds/Pjvktm1Ugds
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 * CBA/Ca

 MP:0003883 enlarged stomach "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003892 abnormal gastric gland "anomaly of any of the branched tubular glands in the mucosa of the fundus and body of the stomach that contain parietal cells that secrete hydrocholric acid and zymogenic cells that produce pepsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004138 abnormal mucous neck cell morphology "malformation of the mucin-producing epithelial cells present in the the neck of the gastric glands " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004140 abnormal chief cell morphology "malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004731 increased circulating gastrin level "greater concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005211 increased thickness of gastric mucosa "greater than the normal depth or width of the epithelial layer of the stomach" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:77398]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0008004 abnormal stomach pH "anomaly in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, as measured by the concentration of the hydrogen ion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0008006 increased stomach pH "change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is decreased, as indicated by the decreased concentration of hydrogen ion" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

 MP:0010799 stomach mucosa hyperplasia "overdevelopment or increased size, usually due to an increase in the number of cells, of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0013569 gastric gland hyperplasia "overdevelopment or increased size, usually due to an increased number of cells, of any of the branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin" [MGI:Anna]
Show

Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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