ENSMUSG00000025496


Mus musculus

Features
Gene ID: ENSMUSG00000025496
  
Biological name :Drd4
  
Synonyms : D(4) dopamine receptor / Drd4 / P51436
  
Possible biological names infered from orthology : dopamine receptor D4 / P21917
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F5
Gene start: 141292006
Gene end: 141296464
  
Corresponding Affymetrix probe sets: 10558866 (MoGene1.0st)   1422829_at (Mouse Genome 430 2.0 Array)   1422830_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026569
NCBI entrez gene - 13491     See in Manteia.
MGI - MGI:94926
RefSeq - XM_017321972
RefSeq - NM_007878
RefSeq - XM_006536156
RefSeq Peptide - NP_031904
swissprot - P51436
Ensembl - ENSMUSG00000025496
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 drd4aENSDARG00000038363Danio rerio
 drd4bENSDARG00000035820Danio rerio
 DRD4ENSGALG00000040761Gallus gallus
 DRD4ENSG00000069696Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Drd3 / P30728 / D(3) dopamine receptor / P35462* / dopamine receptor D3*ENSMUSG0000002270539
Drd2 / P61168 / D(2) dopamine receptor / P14416* / dopamine receptor D2*ENSMUSG0000003225936
Drd5 / Q8BLD9 / D(1B) dopamine receptor / P21918* / dopamine receptor D5*ENSMUSG0000003935828
Htr2b / Q02152 / 5-hydroxytryptamine (serotonin) receptor 2B / P41595* / 5-hydroxytryptamine receptor 2B*ENSMUSG0000002622828
Adrb3 / P25962 / Beta-3 adrenergic receptor / P13945* / adrenoceptor beta 3*ENSMUSG0000003148927
Adrb1 / P34971 / Beta-1 adrenergic receptor / P08588* / adrenoceptor beta 1*ENSMUSG0000003528327
Htr2c / P34968 / 5-hydroxytryptamine (serotonin) receptor 2C / P28335* / 5-hydroxytryptamine receptor 2C*ENSMUSG0000004138027
Htr6 / Q9R1C8 / 5-hydroxytryptamine (serotonin) receptor 6 / P50406* / 5-hydroxytryptamine receptor 6*ENSMUSG0000002874726
Drd1 / Q61616 / D(1A) dopamine receptor / P21728* / dopamine receptor D1*ENSMUSG0000002147826
Htr2a / P35363 / 5-hydroxytryptamine (serotonin) receptor 2A / P28223* / 5-hydroxytryptamine receptor 2A*ENSMUSG0000003499726
Hrh2 / P97292 / Histamine H2 receptor / P25021* / histamine receptor H2*ENSMUSG0000003498726
Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*ENSMUSG0000004573023


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000929  Dopamine receptor family
 IPR002185  Dopamine D4 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001975 response to amphetamine IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway ISS
 biological_processGO:0007212 dopamine receptor signaling pathway ISO
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0032417 positive regulation of sodium:proton antiporter activity IEA
 biological_processGO:0033674 positive regulation of kinase activity IEA
 biological_processGO:0034776 response to histamine IEA
 biological_processGO:0042053 regulation of dopamine metabolic process IMP
 biological_processGO:0042596 fear response IMP
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0048148 behavioral response to cocaine IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0050709 negative regulation of protein secretion IEA
 biological_processGO:0060080 inhibitory postsynaptic potential IMP
 biological_processGO:1901386 negative regulation of voltage-gated calcium channel activity IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004952 dopamine neurotransmitter receptor activity ISO
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0035240 dopamine binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051379 epinephrine binding IEA
 molecular_functionGO:0051380 norepinephrine binding IEA


Pathways (from Reactome)
Pathway description
Dopamine receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Thtm4.1Rpa/Thtm4.1Rpa,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002629 hyperactivity elicited by ethanol administration 
Show

Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Thtm4.1Rpa/Thtm4.1Rpa,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0009750 impaired behavioral response to addictive substance "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009754 enhanced behavioral response to cocaine "increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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