ENSG00000069696


Homo sapiens

Features
Gene ID: ENSG00000069696
  
Biological name :DRD4
  
Synonyms : dopamine receptor D4 / DRD4 / P21917
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.5
Gene start: 637293
Gene end: 640706
  
Corresponding Affymetrix probe sets: 208215_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000176183
NCBI entrez gene - 1815     See in Manteia.
OMIM - 126452
RefSeq - NM_000797
RefSeq Peptide - NP_000788
swissprot - P21917
Ensembl - ENSG00000069696
  
Related genetic diseases (OMIM): 126452 - Autonomic nervous system dysfunction
  143465 - {Attention deficit-hyperactivity disorder}, 143465
  601696 - [Novelty seeking personality], 601696
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 drd4aENSDARG00000038363Danio rerio
 drd4bENSDARG00000035820Danio rerio
 DRD4ENSGALG00000040761Gallus gallus
 Drd4ENSMUSG00000025496Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DRD3 / P35462 / dopamine receptor D3ENSG0000015157736
DRD2 / P14416 / dopamine receptor D2ENSG0000014929534
HTR2B / P41595 / 5-hydroxytryptamine receptor 2BENSG0000013591427
DRD5 / P21918 / dopamine receptor D5ENSG0000016967627
ADRB1 / P08588 / adrenoceptor beta 1ENSG0000004359127
ADRB3 / P13945 / adrenoceptor beta 3ENSG0000018877827
HTR2A / P28223 / 5-hydroxytryptamine receptor 2AENSG0000010246825
DRD1 / P21728 / dopamine receptor D1ENSG0000018484525
HTR6 / P50406 / 5-hydroxytryptamine receptor 6ENSG0000015874825
HTR2C / P28335 / 5-hydroxytryptamine receptor 2CENSG0000014724624
HRH2 / P25021 / histamine receptor H2ENSG0000011374923
ADRB2 / P07550 / adrenoceptor beta 2ENSG0000016925221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000929  Dopamine receptor family
 IPR002185  Dopamine D4 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IDA
 biological_processGO:0001662 behavioral fear response NAS
 biological_processGO:0001975 response to amphetamine IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IC
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway IMP
 biological_processGO:0007212 dopamine receptor signaling pathway IDA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0032417 positive regulation of sodium:proton antiporter activity IDA
 biological_processGO:0033674 positive regulation of kinase activity IDA
 biological_processGO:0034776 response to histamine IDA
 biological_processGO:0035176 social behavior NAS
 biological_processGO:0042053 regulation of dopamine metabolic process IEA
 biological_processGO:0042417 dopamine metabolic process IC
 biological_processGO:0042596 fear response IEA
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0048148 behavioral response to cocaine IEA
 biological_processGO:0048149 behavioral response to ethanol TAS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050482 arachidonic acid secretion IDA
 biological_processGO:0050709 negative regulation of protein secretion IDA
 biological_processGO:0051586 positive regulation of dopamine uptake involved in synaptic transmission IC
 biological_processGO:0060080 inhibitory postsynaptic potential IEA
 biological_processGO:1901386 negative regulation of voltage-gated calcium channel activity IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go IMP
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004952 dopamine neurotransmitter receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IDA
 molecular_functionGO:0015459 potassium channel regulator activity NAS
 molecular_functionGO:0017124 SH3 domain binding IDA
 molecular_functionGO:0035240 dopamine binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051379 epinephrine binding IDA
 molecular_functionGO:0051380 norepinephrine binding IDA


Pathways (from Reactome)
Pathway description
Dopamine receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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