ENSG00000188778


Homo sapiens

Features
Gene ID: ENSG00000188778
  
Biological name :ADRB3
  
Synonyms : ADRB3 / adrenoceptor beta 3 / P13945
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p11.23
Gene start: 37962991
Gene end: 37966965
  
Corresponding Affymetrix probe sets: 206812_at (Human Genome U133 Plus 2.0 Array)   217303_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000343782
NCBI entrez gene - 155     See in Manteia.
OMIM - 109691
RefSeq - NM_000025
RefSeq Peptide - NP_000016
swissprot - A8KAG8
swissprot - P13945
Ensembl - ENSG00000188778
  
Related genetic diseases (OMIM): 601665 - {Obesity, susceptibility to}, 601665
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adrb3aENSDARG00000053646Danio rerio
 adrb3bENSDARG00000052919Danio rerio
 ADRB3ENSGALG00000019018Gallus gallus
 Adrb3ENSMUSG00000031489Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADRB1 / P08588 / adrenoceptor beta 1ENSG0000004359150
ADRB2 / P07550 / adrenoceptor beta 2ENSG0000016925242
DRD5 / P21918 / dopamine receptor D5ENSG0000016967629
HTR6 / P50406 / 5-hydroxytryptamine receptor 6ENSG0000015874829
HRH2 / P25021 / histamine receptor H2ENSG0000011374928
DRD4 / P21917 / dopamine receptor D4ENSG0000006969628
DRD3 / P35462 / dopamine receptor D3ENSG0000015157728
DRD1 / P21728 / dopamine receptor D1ENSG0000018484528
HTR2C / P28335 / 5-hydroxytryptamine receptor 2CENSG0000014724626
DRD2 / P14416 / dopamine receptor D2ENSG0000014929525
HTR2B / P41595 / 5-hydroxytryptamine receptor 2BENSG0000013591425
HTR2A / P28223 / 5-hydroxytryptamine receptor 2AENSG0000010246824


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000681  Beta 3 adrenoceptor
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IBA
 biological_processGO:0002024 diet induced thermogenesis IEA
 biological_processGO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
 biological_processGO:0005975 carbohydrate metabolic process TAS
 biological_processGO:0006091 generation of precursor metabolites and energy TAS
 biological_processGO:0006112 energy reserve metabolic process TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007190 activation of adenylate cyclase activity IDA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0031649 heat generation IEA
 biological_processGO:0040015 negative regulation of multicellular organism growth IEA
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0050873 brown fat cell differentiation IEA
 biological_processGO:0071875 adrenergic receptor signaling pathway IEA
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IEA
 molecular_functionGO:0004939 beta-adrenergic receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015052 beta3-adrenergic receptor activity IMP
 molecular_functionGO:0031699 beta-3 adrenergic receptor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0051379 epinephrine binding IBA
 molecular_functionGO:0051380 norepinephrine binding IDA


Pathways (from Reactome)
Pathway description
Adrenoceptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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