ENSMUSG00000031489


Mus musculus

Features
Gene ID: ENSMUSG00000031489
  
Biological name :Adrb3
  
Synonyms : Adrb3 / Beta-3 adrenergic receptor / P25962
  
Possible biological names infered from orthology : adrenoceptor beta 3 / P13945
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 27225776
Gene end: 27250616
  
Corresponding Affymetrix probe sets: 10577973 (MoGene1.0st)   1421555_at (Mouse Genome 430 2.0 Array)   1455918_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080162
Ensembl peptide - ENSMUSP00000113006
Ensembl peptide - ENSMUSP00000113732
NCBI entrez gene - 11556     See in Manteia.
MGI - MGI:87939
RefSeq - XM_017312525
RefSeq - NM_013462
RefSeq - XM_006508988
RefSeq - XM_011242116
RefSeq - XM_011242117
RefSeq - XM_006508987
RefSeq Peptide - NP_038490
swissprot - P25962
swissprot - Q3UP63
Ensembl - ENSMUSG00000031489
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adrb3aENSDARG00000053646Danio rerio
 adrb3bENSDARG00000052919Danio rerio
 ADRB3ENSGALG00000019018Gallus gallus
 ADRB3ENSG00000188778Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adrb1 / P34971 / Beta-1 adrenergic receptor / P08588* / adrenoceptor beta 1*ENSMUSG0000003528349
Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*ENSMUSG0000004573043
Htr6 / Q9R1C8 / 5-hydroxytryptamine (serotonin) receptor 6 / P50406* / 5-hydroxytryptamine receptor 6*ENSMUSG0000002874730
Drd5 / Q8BLD9 / D(1B) dopamine receptor / P21918* / dopamine receptor D5*ENSMUSG0000003935830
Hrh2 / P97292 / Histamine H2 receptor / P25021* / histamine receptor H2*ENSMUSG0000003498729
Drd3 / P30728 / D(3) dopamine receptor / P35462* / dopamine receptor D3*ENSMUSG0000002270528
Drd1 / Q61616 / D(1A) dopamine receptor / P21728* / dopamine receptor D1*ENSMUSG0000002147828
Drd4 / P51436 / D(4) dopamine receptor / P21917* / dopamine receptor D4*ENSMUSG0000002549627
Drd2 / P61168 / D(2) dopamine receptor / P14416* / dopamine receptor D2*ENSMUSG0000003225926
Htr2c / P34968 / 5-hydroxytryptamine (serotonin) receptor 2C / P28335* / 5-hydroxytryptamine receptor 2C*ENSMUSG0000004138026
Htr2b / Q02152 / 5-hydroxytryptamine (serotonin) receptor 2B / P41595* / 5-hydroxytryptamine receptor 2B*ENSMUSG0000002622825
Htr2a / P35363 / 5-hydroxytryptamine (serotonin) receptor 2A / P28223* / 5-hydroxytryptamine receptor 2A*ENSMUSG0000003499723


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000681  Beta 3 adrenoceptor
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002024 diet induced thermogenesis IGI
 biological_processGO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007190 activation of adenylate cyclase activity ISS
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009409 response to cold IGI
 biological_processGO:0031649 heat generation IGI
 biological_processGO:0040015 negative regulation of multicellular organism growth IGI
 biological_processGO:0042755 eating behavior IEA
 biological_processGO:0043410 positive regulation of MAPK cascade ISS
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0050873 brown fat cell differentiation IGI
 biological_processGO:0071875 adrenergic receptor signaling pathway IEA
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex ISS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IEA
 molecular_functionGO:0004939 beta-adrenergic receptor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015052 beta3-adrenergic receptor activity ISO
 molecular_functionGO:0031699 beta-3 adrenergic receptor binding IDA
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0051379 epinephrine binding IBA
 molecular_functionGO:0051380 norepinephrine binding IBA


Pathways (from Reactome)
Pathway description
Adrenoceptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp7aMo-12H/Atp7a+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Atp7aMo-12H/Atp7a+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp7aMo-12H/Atp7a+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Scnn1atm1Hum/Scnn1atm1Hum
Genetic Background: involves: 129/Sv

 MP:0009119 increased brown fat cell size "increase in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0009294 increased interscapular fat pad weight 
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0009300 increased parametrial fat pad weight 
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Allelic Composition: Scnn1atm1Hum/Scnn1atm1Hum
Genetic Background: involves: 129/Sv

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scnn1atm1Hum/Scnn1atm1Hum
Genetic Background: involves: 129/Sv

Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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