ENSMUSG00000039358


Mus musculus

Features
Gene ID: ENSMUSG00000039358
  
Biological name :Drd5
  
Synonyms : D(1B) dopamine receptor / Drd5 / Q8BLD9
  
Possible biological names infered from orthology : dopamine receptor D5 / P21918
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B3
Gene start: 38319367
Gene end: 38322518
  
Corresponding Affymetrix probe sets: 10521583 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000039691
NCBI entrez gene - 13492     See in Manteia.
MGI - MGI:94927
RefSeq - NM_013503
RefSeq Peptide - NP_038531
swissprot - B2RQS5
swissprot - Q8BLD9
Ensembl - ENSMUSG00000039358
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX530018.1ENSDARG00000037576Danio rerio
 DRD5ENSGALG00000014975Gallus gallus
 DRD5ENSG00000169676Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Drd1 / Q61616 / D(1A) dopamine receptor / P21728* / dopamine receptor D1*ENSMUSG0000002147853
Adrb1 / P34971 / Beta-1 adrenergic receptor / P08588* / adrenoceptor beta 1*ENSMUSG0000003528328
Hrh2 / P97292 / Histamine H2 receptor / P25021* / histamine receptor H2*ENSMUSG0000003498727
Drd2 / P61168 / D(2) dopamine receptor / P14416* / dopamine receptor D2*ENSMUSG0000003225926
Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*ENSMUSG0000004573026
Htr6 / Q9R1C8 / 5-hydroxytryptamine (serotonin) receptor 6 / P50406* / 5-hydroxytryptamine receptor 6*ENSMUSG0000002874726
Drd3 / P30728 / D(3) dopamine receptor / P35462* / dopamine receptor D3*ENSMUSG0000002270525
Adrb3 / P25962 / Beta-3 adrenergic receptor / P13945* / adrenoceptor beta 3*ENSMUSG0000003148925
Drd4 / P51436 / D(4) dopamine receptor / P21917* / dopamine receptor D4*ENSMUSG0000002549623
Htr2b / Q02152 / 5-hydroxytryptamine (serotonin) receptor 2B / P41595* / 5-hydroxytryptamine receptor 2B*ENSMUSG0000002622823
Htr2a / P35363 / 5-hydroxytryptamine (serotonin) receptor 2A / P28223* / 5-hydroxytryptamine receptor 2A*ENSMUSG0000003499721
Htr2c / P34968 / 5-hydroxytryptamine (serotonin) receptor 2C / P28335* / 5-hydroxytryptamine receptor 2C*ENSMUSG0000004138021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000497  Dopamine D5 receptor
 IPR000929  Dopamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001975 response to amphetamine IGI
 biological_processGO:0001992 regulation of systemic arterial blood pressure by vasopressin IGI
 biological_processGO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IBA
 biological_processGO:0007212 dopamine receptor signaling pathway IEA
 biological_processGO:0007617 mating behavior IMP
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0019226 transmission of nerve impulse IMP
 biological_processGO:0033861 negative regulation of NAD(P)H oxidase activity ISO
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0042220 response to cocaine IMP
 biological_processGO:0045776 negative regulation of blood pressure IMP
 biological_processGO:0045924 regulation of female receptivity IMP
 biological_processGO:0046960 sensitization IGI
 biological_processGO:0060158 phospholipase C-activating dopamine receptor signaling pathway IBA
 biological_processGO:0060292 long term synaptic depression IMP
 biological_processGO:0071870 cellular response to catecholamine stimulus ISO
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031526 brush border membrane IDA
 cellular_componentGO:0060170 ciliary membrane ISO
 cellular_componentGO:0097730 non-motile cilium IEA
 molecular_functionGO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs IMP
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004952 dopamine neurotransmitter receptor activity ISO
 molecular_functionGO:0035240 dopamine binding ISO


Pathways (from Reactome)
Pathway description
Dopamine receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Card11tm1Vmd/Card11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11tm1Vmd/Card11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Drd5tm1Sib/Drd5tm1Sib
Genetic Background: B6.129S4-Drd5tm1Sib

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

Allelic Composition: Drd5tm1.1Stl/Drd5tm1.1Stl
Genetic Background: involves: C57BL/6

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd1tm2.1Stl/Drd1tm2.1Stl
Genetic Background: involves: C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Card11tm1Vmd/Card11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11tm1Vmd/Card11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Drd5tm1Sib/Drd5tm1Sib
Genetic Background: B6.129S4-Drd5tm1Sib

 MP:0002909 abnormal adrenal gland physiology "altered ability of the surparenal gland to produce and secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Card11tm1Vmd/Card11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0003460 decreased fear-related response "reduced emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Drd1tm2.1Stl/Drd1tm2.1Stl
Genetic Background: involves: C57BL/6

 MP:0004183 abnormal sympathetic nervous system physiology "anomaly in the function of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11tm1Vmd/Card11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11tm1Vmd/Card11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Drd5tm1Sib/Drd5tm1Sib
Genetic Background: B6.129S4-Drd5tm1Sib

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11tm1Vmd/Card11+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Drd5tm1Sib/Drd5tm1Sib
Genetic Background: B6.129S4-Drd5tm1Sib

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd1tm2.1Stl/Drd1tm2.1Stl
Genetic Background: involves: C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Drd1tm2.1Stl/Drd1tm2.1Stl
Genetic Background: involves: C57BL/6

 MP:0012733 abnormal behavioral response to methamphetamine "anomaly in the behavioral response induced by methamphetamine such as induced hyperactivity or stereotypic behavior" [MPD:Molly]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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