ENSMUSG00000022705


Mus musculus

Features
Gene ID: ENSMUSG00000022705
  
Biological name :Drd3
  
Synonyms : D(3) dopamine receptor / Drd3 / P30728
  
Possible biological names infered from orthology : dopamine receptor D3 / P35462
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B4
Gene start: 43754026
Gene end: 43822932
  
Corresponding Affymetrix probe sets: 10435793 (MoGene1.0st)   1422278_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023390
Ensembl peptide - ENSMUSP00000155033
NCBI entrez gene - 13490     See in Manteia.
MGI - MGI:94925
RefSeq - XM_006521777
RefSeq - NM_007877
RefSeq Peptide - NP_031903
swissprot - P30728
swissprot - Q0VEC4
Ensembl - ENSMUSG00000022705
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 drd3ENSDARG00000032131Danio rerio
 DRD3ENSGALG00000015117Gallus gallus
 DRD3ENSG00000151577Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Drd2 / P61168 / D(2) dopamine receptor / P14416* / dopamine receptor D2*ENSMUSG0000003225950
Drd4 / P51436 / D(4) dopamine receptor / P21917* / dopamine receptor D4*ENSMUSG0000002549633
Adrb1 / P34971 / Beta-1 adrenergic receptor / P08588* / adrenoceptor beta 1*ENSMUSG0000003528326
Drd5 / Q8BLD9 / D(1B) dopamine receptor / P21918* / dopamine receptor D5*ENSMUSG0000003935826
Drd1 / Q61616 / D(1A) dopamine receptor / P21728* / dopamine receptor D1*ENSMUSG0000002147825
Htr2c / P34968 / 5-hydroxytryptamine (serotonin) receptor 2C / P28335* / 5-hydroxytryptamine receptor 2C*ENSMUSG0000004138025
Adrb3 / P25962 / Beta-3 adrenergic receptor / P13945* / adrenoceptor beta 3*ENSMUSG0000003148925
Htr2a / P35363 / 5-hydroxytryptamine (serotonin) receptor 2A / P28223* / 5-hydroxytryptamine receptor 2A*ENSMUSG0000003499724
Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*ENSMUSG0000004573024
Htr2b / Q02152 / 5-hydroxytryptamine (serotonin) receptor 2B / P41595* / 5-hydroxytryptamine receptor 2B*ENSMUSG0000002622823
Hrh2 / P97292 / Histamine H2 receptor / P25021* / histamine receptor H2*ENSMUSG0000003498723
Htr6 / Q9R1C8 / 5-hydroxytryptamine (serotonin) receptor 6 / P50406* / 5-hydroxytryptamine receptor 6*ENSMUSG0000002874722


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000929  Dopamine receptor family
 IPR001620  Dopamine D3 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001963 synaptic transmission, dopaminergic IEA
 biological_processGO:0001975 response to amphetamine IGI
 biological_processGO:0002016 regulation of blood volume by renin-angiotensin IMP
 biological_processGO:0002031 G-protein coupled receptor internalization IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IEA
 biological_processGO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway ISO
 biological_processGO:0007212 dopamine receptor signaling pathway IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0014059 regulation of dopamine secretion IMP
 biological_processGO:0019216 regulation of lipid metabolic process IMP
 biological_processGO:0030814 obsolete regulation of cAMP metabolic process IEA
 biological_processGO:0032416 negative regulation of sodium:proton antiporter activity IEA
 biological_processGO:0032467 positive regulation of cytokinesis IEA
 biological_processGO:0032922 circadian regulation of gene expression IMP
 biological_processGO:0034776 response to histamine IEA
 biological_processGO:0035483 gastric emptying IEA
 biological_processGO:0035815 positive regulation of renal sodium excretion IEA
 biological_processGO:0040012 regulation of locomotion IEA
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0042220 response to cocaine IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043278 response to morphine IMP
 biological_processGO:0045187 regulation of circadian sleep/wake cycle, sleep IEA
 biological_processGO:0045471 response to ethanol IMP
 biological_processGO:0045776 negative regulation of blood pressure IMP
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046717 acid secretion IEA
 biological_processGO:0048148 behavioral response to cocaine IMP
 biological_processGO:0048715 negative regulation of oligodendrocyte differentiation IDA
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0050709 negative regulation of protein secretion IEA
 biological_processGO:0050883 musculoskeletal movement, spinal reflex action IMP
 biological_processGO:0051898 negative regulation of protein kinase B signaling IMP
 biological_processGO:0060134 prepulse inhibition IEA
 biological_processGO:0060160 negative regulation of dopamine receptor signaling pathway IGI
 biological_processGO:0060161 positive regulation of dopamine receptor signaling pathway IMP
 biological_processGO:0090325 regulation of locomotion involved in locomotory behavior IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045177 apical part of cell IEA
 molecular_functionGO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004952 dopamine neurotransmitter receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031748 D1 dopamine receptor binding IEA
 molecular_functionGO:0035240 dopamine binding IEA


Pathways (from Reactome)
Pathway description
Dopamine receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000676 abnormal water content "more or less than the normal total amount of water retained in the body" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: F7tm1Pec/F7tm1Pec,Proctm1Fjc/Proctm1Fjc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Drd3tm1Dac/Drd3+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: B6.129S4-Drd3tm1Dac/J

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm1Schm/Drd2+,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Drd3tm1Dac/Drd3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: B6.129S4-Drd3tm1Dac/J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Sall4tm1Ryn/Sall4tm1Ryn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Drd3tm1Dac/Drd3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001442 decreased grooming behavior "reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gli2tm1Alj/Gli2+,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

Allelic Composition: Drd3tm1Dac/Drd3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: B6.129S4-Drd3tm1Dac/J

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001666 abnormal nutrient absorption "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: B6.129S4-Drd3tm1Dac/J

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: B6.129S4-Drd3tm1Dac/J

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Drd3tm1Dac/Drd3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: B6.129S4-Drd3tm1Dac/J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Drd3tm1Dac/Drd3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003546 decreased alcohol consumption "less than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

 MP:0003866 abnormal defecation "anomaly in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003867 increased defecation "increase in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

 MP:0005582 increased renin activity "greater than the normal ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Drd3tm1Dac/Drd3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
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Allelic Composition: Sall4tm1Ryn/Sall4tm1Ryn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

 MP:0006001 abnormal intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the intestine" [smb:Susan M Bello, Mouse Genome Iformatics Curator]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

 MP:0006003 abnormal large intestinal transit time "increase or decrease in the time it takes for a bolus of material to pass through the large intestine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Drd3tm1Dac/Drd3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Drd3tm1Dac/Drd3+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: B6.129S4-Drd3tm1Dac/J

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009748 abnormal behavioral response to addictive substance "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd
Genetic Background: B6.129S4-Drd1tm1Jcd/J

Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

 MP:0009751 enhanced behavioral response to alcohol "increased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

 MP:0009757 impaired behavioral response to morphine "decreased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009775 increased behavioral withdrawal response "increase in the intensity or duration of behaviors displayed after discontinuation of an addictive substance" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011432 decreased urine flow rate "reduced volume of urine produced in a specified period of time" [MGI:anna]
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Allelic Composition: Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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