ENSMUSG00000028747


Mus musculus

Features
Gene ID: ENSMUSG00000028747
  
Biological name :Htr6
  
Synonyms : 5-hydroxytryptamine (serotonin) receptor 6 / Htr6 / Q9R1C8
  
Possible biological names infered from orthology : 5-hydroxytryptamine receptor 6 / P50406
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 139061108
Gene end: 139075570
  
Corresponding Affymetrix probe sets: 10517673 (MoGene1.0st)   1421757_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068333
Ensembl peptide - ENSMUSP00000101428
NCBI entrez gene - 15565     See in Manteia.
MGI - MGI:1196627
RefSeq - XM_011250196
RefSeq - NM_021358
RefSeq Peptide - NP_067333
swissprot - Q14AW8
swissprot - Q9R1C8
Ensembl - ENSMUSG00000028747
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr6ENSDARG00000016095Danio rerio
 HTR6ENSGALG00000004066Gallus gallus
 HTR6ENSG00000158748Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adrb1 / P34971 / Beta-1 adrenergic receptor / P08588* / adrenoceptor beta 1*ENSMUSG0000003528330
Drd5 / Q8BLD9 / D(1B) dopamine receptor / P21918* / dopamine receptor D5*ENSMUSG0000003935828
Adrb3 / P25962 / Beta-3 adrenergic receptor / P13945* / adrenoceptor beta 3*ENSMUSG0000003148927
Drd1 / Q61616 / D(1A) dopamine receptor / P21728* / dopamine receptor D1*ENSMUSG0000002147826
Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*ENSMUSG0000004573025
Hrh2 / P97292 / Histamine H2 receptor / P25021* / histamine receptor H2*ENSMUSG0000003498724
Htr2b / Q02152 / 5-hydroxytryptamine (serotonin) receptor 2B / P41595* / 5-hydroxytryptamine receptor 2B*ENSMUSG0000002622824
Drd3 / P30728 / D(3) dopamine receptor / P35462* / dopamine receptor D3*ENSMUSG0000002270523
Drd4 / P51436 / D(4) dopamine receptor / P21917* / dopamine receptor D4*ENSMUSG0000002549623
Drd2 / P61168 / D(2) dopamine receptor / P14416* / dopamine receptor D2*ENSMUSG0000003225923
Htr2a / P35363 / 5-hydroxytryptamine (serotonin) receptor 2A / P28223* / 5-hydroxytryptamine receptor 2A*ENSMUSG0000003499723
Htr2c / P34968 / 5-hydroxytryptamine (serotonin) receptor 2C / P28335* / 5-hydroxytryptamine receptor 2C*ENSMUSG0000004138022


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002232  5-Hydroxytryptamine 6 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0021795 cerebral cortex cell migration IMP
 biological_processGO:0032008 positive regulation of TOR signaling ISO
 biological_processGO:0098664 G-protein coupled serotonin receptor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030594 neurotransmitter receptor activity IBA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Baxtm1Dlo/Baxtm1Dlo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Htr6tm1Arte/Htr6tm1Arte
Genetic Background: involves: C57BL/6

 MP:0002629 hyperactivity elicited by ethanol administration 
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009755 impaired behavioral response to alcohol "decreased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hoxc4tm1Mrc/Hoxc4+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Htr6tm1Arte/Htr6tm1Arte
Genetic Background: involves: C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Htr6tm1Arte/Htr6tm1Arte
Genetic Background: involves: C57BL/6

 MP:0020234 decreased basal metabolism "decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [GOC:NV]
Show

Allelic Composition: Htr6tm1Arte/Htr6tm1Arte
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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