ENSMUSG00000021478


Mus musculus

Features
Gene ID: ENSMUSG00000021478
  
Biological name :Drd1
  
Synonyms : D(1A) dopamine receptor / Drd1 / Q61616
  
Possible biological names infered from orthology : dopamine receptor D1 / P21728
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 54051183
Gene end: 54055705
  
Corresponding Affymetrix probe sets: 10409319 (MoGene1.0st)   1455629_at (Mouse Genome 430 2.0 Array)   1456051_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021932
Ensembl peptide - ENSMUSP00000152768
NCBI entrez gene - 13488     See in Manteia.
MGI - MGI:99578
RefSeq - NM_001291801
RefSeq - NM_010076
RefSeq Peptide - NP_001278730
RefSeq Peptide - NP_034206
swissprot - Q61616
swissprot - A0A1Y7VK92
Ensembl - ENSMUSG00000021478
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 drd1aENSDARG00000071640Danio rerio
 drd1bENSDARG00000038918Danio rerio
 DRD1ENSGALG00000039698Gallus gallus
 DRD1ENSG00000184845Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Drd5 / Q8BLD9 / D(1B) dopamine receptor / P21918* / dopamine receptor D5*ENSMUSG0000003935857
Adrb1 / P34971 / Beta-1 adrenergic receptor / P08588* / adrenoceptor beta 1*ENSMUSG0000003528330
Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*ENSMUSG0000004573028
Hrh2 / P97292 / Histamine H2 receptor / P25021* / histamine receptor H2*ENSMUSG0000003498727
Htr6 / Q9R1C8 / 5-hydroxytryptamine (serotonin) receptor 6 / P50406* / 5-hydroxytryptamine receptor 6*ENSMUSG0000002874726
Htr2b / Q02152 / 5-hydroxytryptamine (serotonin) receptor 2B / P41595* / 5-hydroxytryptamine receptor 2B*ENSMUSG0000002622825
Drd3 / P30728 / D(3) dopamine receptor / P35462* / dopamine receptor D3*ENSMUSG0000002270525
Adrb3 / P25962 / Beta-3 adrenergic receptor / P13945* / adrenoceptor beta 3*ENSMUSG0000003148925
Drd2 / P61168 / D(2) dopamine receptor / P14416* / dopamine receptor D2*ENSMUSG0000003225925
Htr2a / P35363 / 5-hydroxytryptamine (serotonin) receptor 2A / P28223* / 5-hydroxytryptamine receptor 2A*ENSMUSG0000003499724
Htr2c / P34968 / 5-hydroxytryptamine (serotonin) receptor 2C / P28335* / 5-hydroxytryptamine receptor 2C*ENSMUSG0000004138022
Drd4 / P51436 / D(4) dopamine receptor / P21917* / dopamine receptor D4*ENSMUSG0000002549622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000929  Dopamine receptor family
 IPR001413  Dopamine D1 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IMP
 biological_processGO:0001661 conditioned taste aversion IMP
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0001932 regulation of protein phosphorylation IMP
 biological_processGO:0001963 synaptic transmission, dopaminergic IMP
 biological_processGO:0001975 response to amphetamine IMP
 biological_processGO:0006606 protein import into nucleus IMP
 biological_processGO:0006936 muscle contraction IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007190 activation of adenylate cyclase activity IEA
 biological_processGO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IEA
 biological_processGO:0007212 dopamine receptor signaling pathway IMP
 biological_processGO:0007612 learning IMP
 biological_processGO:0007613 memory IMP
 biological_processGO:0007617 mating behavior IDA
 biological_processGO:0007625 grooming behavior IMP
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0007631 feeding behavior IGI
 biological_processGO:0008306 associative learning IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014002 astrocyte development IMP
 biological_processGO:0015872 dopamine transport IMP
 biological_processGO:0019226 transmission of nerve impulse IMP
 biological_processGO:0019228 neuronal action potential IMP
 biological_processGO:0021542 dentate gyrus development IMP
 biological_processGO:0021756 striatum development IMP
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0021853 cerebral cortex GABAergic interneuron migration IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030432 peristalsis IGI
 biological_processGO:0035106 operant conditioning IMP
 biological_processGO:0042053 regulation of dopamine metabolic process IMP
 biological_processGO:0042220 response to cocaine IMP
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0042711 maternal behavior IMP
 biological_processGO:0043987 histone H3-S10 phosphorylation IDA
 biological_processGO:0046323 glucose import IMP
 biological_processGO:0046959 habituation IMP
 biological_processGO:0046960 sensitization IGI
 biological_processGO:0048148 behavioral response to cocaine IMP
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA
 biological_processGO:0051968 positive regulation of synaptic transmission, glutamatergic IMP
 biological_processGO:0060158 phospholipase C-activating dopamine receptor signaling pathway IEA
 biological_processGO:0060291 long-term synaptic potentiation IMP
 biological_processGO:0060292 long term synaptic depression IMP
 biological_processGO:0071870 cellular response to catecholamine stimulus IEA
 biological_processGO:1903351 cellular response to dopamine IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0012505 endomembrane system IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0060170 ciliary membrane IEA
 cellular_componentGO:0097730 non-motile cilium IEA
 molecular_functionGO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IDA
 molecular_functionGO:0004952 dopamine neurotransmitter receptor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035240 dopamine binding IEA


Pathways (from Reactome)
Pathway description
Dopamine receptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000470 abnormal stomach morphology "malformation of the sac-like structure of the digestive canal between the esophagus and the small intestine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

Allelic Composition: Drd1tm1(cre)Rpa/Drd1tm1(cre)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prkar2btm3Gsm/Prkar2btm2Gsm,Drd1tm1(cre)Rpa/Drd1+
Genetic Background: involves: C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

Allelic Composition: Drd1tm1Jcd/Drd1+
Genetic Background: involves: 129S4/SvJae

 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Drd1tm1(cre)Rpa/Drd1+,Gad1tm1Rpa/Gad1tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd1tm1(cre)Rpa/Drd1tm1(cre)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bhlhe22tm3.1(cre)Meg/Bhlhe22tm1Meg,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic Background: involves: 129/Sv * 129S4/SvJaeSor

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Flt4tm1Ali/Flt4+,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Drd1tm2.1Stl/Drd1tm2.1Stl
Genetic Background: involves: C57BL/6

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd1tm2.1Stl/Drd1tm2.1Stl
Genetic Background: involves: C57BL/6

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002574 increased vertical activity "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos3tm1Plh/Nos3tm1Plh
Genetic Background: B6.129S4-Nos3tm1Plh

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd3tm1Dac/Drd3tm1Dac
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002799 abnormal passive avoidance behavior "defects in the ability of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously with prolonged latency" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Drd1tm1Jcd/Drd1+
Genetic Background: involves: 129S4/SvJae

 MP:0002803 abnormal operant conditional behavior "defects in the operant conditioning system refers to abnormalities in scheduled controlled behavior; behavioral assessment occurs in an automated chamber where responses are reinforced with food" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Adamts1tm1Dgen/Adamts1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003246 loss of GABA neurons "loss of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd
Genetic Background: involves: 129S4/SvJae

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0003460 decreased fear-related response "reduced emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Drd1tm2.1Stl/Drd1tm2.1Stl
Genetic Background: involves: C57BL/6

Allelic Composition: Drd1tm2.1Stl/Drd1tm2.1Stl,Tg(Pomc-cre)1Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0004077 abnormal striatum morphology "malformation of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cpa3tm3(icre)Hrr/Cpa3+,Gt(ROSA)26Sortm1Hjf/?,Notch1tm1Agt/Notch1tm1Agt
Genetic Background: involves: 129 * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd1tm1(cre)Rpa/Drd1tm1(cre)Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Flt4tm1Ali/Flt4+,Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic Background: involves: C57BL/6

 MP:0005574 decreased breathing frequency "fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005645 abnormal hypothalamus physiology "anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd
Genetic Background: involves: 129S4/SvJae

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0008802 abnormal intestinal smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue lining the intestine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd
Genetic Background: B6.129S4-Drd1tm1Jcd/J

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd1tm2.1Stl/Drd1tm2.1Stl
Genetic Background: involves: C57BL/6

Allelic Composition: Drd1tm2.1Stl/Drd1tm2.1Stl,Tg(Pomc-cre)1Lowl/0
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd1tm1.1Mmsh/Drd1tm1.1Mmsh,Gng7tm1(cre)Mmsh/?
Genetic Background: involves: C57BL/6N

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009758 impaired behavioral response to cocaine "decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf5tm1Tzi/Fgf5tm1Tzi,Fgf6tm1Thbr/Fgf6tm1Thbr,Fgf7tm1Efu/Fgf7tm1Efu
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd
Genetic Background: B6.129S4-Drd1tm1Jcd/J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Drd1tm1(cre)Rpa/Drd1+,Gad1tm1Rpa/Gad1tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010167 decreased response to stress-induced hyperthermia "reduction or absence of the expected increase in core body termperature in response to stress or anticipatory anxiety" [PMID:18722480]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd
Genetic Background: B6.129S4-Drd1tm1Jcd/J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd,Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Drd1tm2.1Stl/Drd1tm2.1Stl
Genetic Background: involves: C57BL/6

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0012468 decreased striatum area "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith]
Show

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Drd1tm1Stl/Drd1tm1Stl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012559 decreased forebrain volume "decrease from the average range of forebrain volume compared to normal" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Runx1tm4Spe/Runx1tm4Spe
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0020083 decreased hippocampus volume "decrease from the average range of the hippocampus volume compared to normal" [GOC:NV]
Show

Allelic Composition: Drd1tm2Jcd/Drd1+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * FVB/N

 MP:0020340 abnormal inhibitory learning "anomaly in the process by which a subject learns to suppress a prior learned response" [http://cognitivedefusion.tumblr.com/post/90402024947/what-is-inhibitory-learning, ORCID: orcid.org/0000-0003-4606-0597, PMID:19321764]
Show

Allelic Composition: Drd1tm1Jcd/Drd1tm1Jcd
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr