ENSMUSG00000041380


Mus musculus

Features
Gene ID: ENSMUSG00000041380
  
Biological name :Htr2c
  
Synonyms : 5-hydroxytryptamine (serotonin) receptor 2C / Htr2c / P34968
  
Possible biological names infered from orthology : 5-hydroxytryptamine receptor 2C / P28335
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F2
Gene start: 146962513
Gene end: 147197277
  
Corresponding Affymetrix probe sets: 10602261 (MoGene1.0st)   1435513_at (Mouse Genome 430 2.0 Array)   1450477_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108450
Ensembl peptide - ENSMUSP00000138772
Ensembl peptide - ENSMUSP00000043936
Ensembl peptide - ENSMUSP00000094021
NCBI entrez gene - 15560     See in Manteia.
MGI - MGI:96281
RefSeq - NM_008312
RefSeq Peptide - NP_032338
swissprot - B1ATN4
swissprot - P34968
swissprot - S4R2T0
Ensembl - ENSMUSG00000041380
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr2cl1ENSDARG00000018228Danio rerio
 HTR2CENSGALG00000005853Gallus gallus
 HTR2CENSG00000147246Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Htr2a / P35363 / 5-hydroxytryptamine (serotonin) receptor 2A / P28223* / 5-hydroxytryptamine receptor 2A*ENSMUSG0000003499750
Htr2b / Q02152 / 5-hydroxytryptamine (serotonin) receptor 2B / P41595* / 5-hydroxytryptamine receptor 2B*ENSMUSG0000002622839
Drd2 / P61168 / D(2) dopamine receptor / P14416* / dopamine receptor D2*ENSMUSG0000003225926
Adrb1 / P34971 / Beta-1 adrenergic receptor / P08588* / adrenoceptor beta 1*ENSMUSG0000003528324
Drd3 / P30728 / D(3) dopamine receptor / P35462* / dopamine receptor D3*ENSMUSG0000002270524
Drd4 / P51436 / D(4) dopamine receptor / P21917* / dopamine receptor D4*ENSMUSG0000002549623
Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*ENSMUSG0000004573023
Drd1 / Q61616 / D(1A) dopamine receptor / P21728* / dopamine receptor D1*ENSMUSG0000002147822
Adrb3 / P25962 / Beta-3 adrenergic receptor / P13945* / adrenoceptor beta 3*ENSMUSG0000003148922
Drd5 / Q8BLD9 / D(1B) dopamine receptor / P21918* / dopamine receptor D5*ENSMUSG0000003935822
Htr6 / Q9R1C8 / 5-hydroxytryptamine (serotonin) receptor 6 / P50406* / 5-hydroxytryptamine receptor 6*ENSMUSG0000002874721
Hrh2 / P97292 / Histamine H2 receptor / P25021* / histamine receptor H2*ENSMUSG0000003498720


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000377  5-Hydroxytryptamine 2C receptor
 IPR002231  5-hydroxytryptamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0006182 cGMP biosynthetic process IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007208 phospholipase C-activating serotonin receptor signaling pathway IMP
 biological_processGO:0007210 serotonin receptor signaling pathway IEA
 biological_processGO:0007610 behavior IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0010513 positive regulation of phosphatidylinositol biosynthetic process IEA
 biological_processGO:0031644 regulation of neurological system process IMP
 biological_processGO:0032098 regulation of appetite IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043397 regulation of corticotropin-releasing hormone secretion IMP
 biological_processGO:0045600 positive regulation of fat cell differentiation IMP
 biological_processGO:0048016 inositol phosphate-mediated signaling ISO
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0098664 G-protein coupled serotonin receptor signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001587 Gq/11-coupled serotonin receptor activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0030594 neurotransmitter receptor activity IBA
 molecular_functionGO:0051378 serotonin binding IEA
 molecular_functionGO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding IEA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

Allelic Composition: Htr2ctm1Jke/Y
Genetic Background: B6.129-Htr2ctm1Jke

 MP:0000421 mottled coat "coat has spots, streaks, and/or blotches of a different color" [J:17194]
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Allelic Composition: Htr2ctm1.1Eme/Y
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Htr2ctm1Knk/Htr2ctm1Knk
Genetic Background: C.Cg-Htr2ctm1Knk

Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

Allelic Composition: Htr2ctm1.1Eme/Y
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc-cre/ERT2)#Jke/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc-cre/ERT2)#Jke/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Htr2ctm1Knk/Htr2ctm1Knk
Genetic Background: C.Cg-Htr2ctm1Knk

Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

Allelic Composition: Htr2ctm1.1Eme/Y
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Htr2ctm1.1Eme/Htr2c+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Htr2ctm1.1Eme/Htr2ctm1.1Eme
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Htr2ctm1Jke/Y
Genetic Background: B6.129-Htr2ctm1Jke

Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Htr2ctm1.1Eme/Y
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd,Tg(Drd2-cre)ER44Gsat/0,Tg(Drd2-EGFP)S118Gsat/0
Genetic Background: involves: C57BL/6 * FVB/N * FVB/NTac

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

Allelic Composition: Htr2ctm1Knk/Y,Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Htr2ctm1Jke/Y
Genetic Background: B6.129-Htr2ctm1Jke

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

 MP:0001492 piloerection "the involuntary bristling of hairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd,Tg(Drd2-cre)ER44Gsat/0,Tg(Drd2-EGFP)S118Gsat/0
Genetic Background: involves: C57BL/6 * FVB/N * FVB/NTac

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Htr2ctm1.1Eme/Y
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

Allelic Composition: Htr2ctm2Jke/Y,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

Allelic Composition: Htr2ctm1.1Eme/Y
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Htr2ctm1.1Eme/Htr2c+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Htr2ctm1.1Eme/Htr2ctm1.1Eme
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ssbtm1Rjma/Ssbtm2.1Rjma,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S/SvEv * BALB/c

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc-cre/ERT2)#Jke/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc-cre/ERT2)#Jke/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

Allelic Composition: Htr2ctm1Jke/Y
Genetic Background: B6.129-Htr2ctm1Jke

Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

Allelic Composition: Htr2ctm2Jke/Y,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0002712 increased circulating glucagon level "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc-cre/ERT2)#Jke/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc-cre/ERT2)#Jke/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0002826 tonic seizures "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0003063 increased coping response "enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Htr2ctm1Jke/Y
Genetic Background: B6.129-Htr2ctm1Jke

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

Allelic Composition: Htr2ctm1Jke/Y
Genetic Background: B6.129-Htr2ctm1Jke

Allelic Composition: Htr2ctm1Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: B6.Cg-Htr2ctm1Jke Tg(Pomc1-cre)16Lowl

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0004129 abnormal respiratory quotient "anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism" [J:94416]
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Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Htr2ctm1.1Eme/Y
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Htr2ctm1.1Eme/Y
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005123 increased circulating growth hormone level "greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc-cre/ERT2)#Jke/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc-cre/ERT2)#Jke/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Htr2ctm1Jke/Y
Genetic Background: B6.129-Htr2ctm1Jke

 MP:0005535 abnormal body temperature "deviation in the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc-cre/ERT2)#Jke/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc-cre/ERT2)#Jke/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

Allelic Composition: Htr2ctm1Jke/Y
Genetic Background: B6.129-Htr2ctm1Jke

Allelic Composition: Htr2ctm2Jke/Y,Tg(Zp3-cre)93Knw/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

Allelic Composition: Htr2ctm1Jke/Y
Genetic Background: B6.129-Htr2ctm1Jke

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Htr2ctm1Knk/Htr2ctm1Knk
Genetic Background: C.Cg-Htr2ctm1Knk

Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

Allelic Composition: Htr2ctm1Knk/Y,Mc4rtm1Lowl/Mc4rtm1Lowl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ghrhrlit/Ghrhrlit,M14104Asr/M14104Asr+
Genetic Background: C57BL/6J-Ghrhrlit M14104Asr

Allelic Composition: Htr2ctm1Knk/Htr2ctm1Knk
Genetic Background: C.Cg-Htr2ctm1Knk

Allelic Composition: Htr2ctm1Knk/Htr2ctm1Knk
Genetic Background: B6.Cg-Htr2ctm1Knk

Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

Allelic Composition: Htr2ctm1Knk/Htr2c+
Genetic Background: B6.Cg-Htr2ctm1Knk

Allelic Composition: Htr2ctm1Knk/Htr2ctm2Knk
Genetic Background: B6.Cg-Htr2ctm1Knk/Htr2ctm2Knk

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0008965 increased basal metabolism "increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [MESH:E01.370.374.750.100]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0009288 increased epididymal fat pad weight 
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

 MP:0009302 increased renal fat pad weight 
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

Allelic Composition: Htr2ctm1Jul/Y
Genetic Background: B6.129S-Htr2ctm1Jul

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

Allelic Composition: Htr2ctm1Jke/Y
Genetic Background: B6.129-Htr2ctm1Jke

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Htr2ctm1.1Eme/Y
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
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Allelic Composition: Htr2ctm1.1Eme/Y
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Htr2ctm1Knk/Htr2ctm1Knk
Genetic Background: B6.Cg-Htr2ctm1Knk

Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

Allelic Composition: Htr2ctm1.1Eme/Y
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0011612 increased circulating ghrelin level "greater than the normal blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that normally stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland" [MGI:anna]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Htr2ctm1.1Eme/Y
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Htr2ctm2Jke/Htr2ctm2Jke,Tg(Pomc-cre/ERT2)#Jke/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Htr2ctm2Jke/Y,Tg(Pomc-cre/ERT2)#Jke/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Htr2ctm1.1Eme/Y
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Htr2ctm1.1Eme/Htr2c+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
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Allelic Composition: Htr2ctm1Knk/Y
Genetic Background: B6.Cg-Htr2ctm1Knk

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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