ENSMUSG00000035283


Mus musculus

Features
Gene ID: ENSMUSG00000035283
  
Biological name :Adrb1
  
Synonyms : Adrb1 / Beta-1 adrenergic receptor / P34971
  
Possible biological names infered from orthology : adrenoceptor beta 1 / P08588
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 56722372
Gene end: 56724862
  
Corresponding Affymetrix probe sets: 10464167 (MoGene1.0st)   1423420_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040847
NCBI entrez gene - 11554     See in Manteia.
MGI - MGI:87937
RefSeq - NM_007419
RefSeq Peptide - NP_031445
swissprot - P34971
Ensembl - ENSMUSG00000035283
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adrb1ENSDARG00000007490Danio rerio
 ADRB1ENSGALG00000008949Gallus gallus
 ADRB1ENSG00000043591Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adrb2 / P18762 / Beta-2 adrenergic receptor / P07550* / adrenoceptor beta 2*ENSMUSG0000004573044
Adrb3 / P25962 / Beta-3 adrenergic receptor / P13945* / adrenoceptor beta 3*ENSMUSG0000003148942
Drd5 / Q8BLD9 / D(1B) dopamine receptor / P21918* / dopamine receptor D5*ENSMUSG0000003935829
Drd1 / Q61616 / D(1A) dopamine receptor / P21728* / dopamine receptor D1*ENSMUSG0000002147829
Htr6 / Q9R1C8 / 5-hydroxytryptamine (serotonin) receptor 6 / P50406* / 5-hydroxytryptamine receptor 6*ENSMUSG0000002874728
Hrh2 / P97292 / Histamine H2 receptor / P25021* / histamine receptor H2*ENSMUSG0000003498726
Drd3 / P30728 / D(3) dopamine receptor / P35462* / dopamine receptor D3*ENSMUSG0000002270525
Drd2 / P61168 / D(2) dopamine receptor / P14416* / dopamine receptor D2*ENSMUSG0000003225924
Htr2b / Q02152 / 5-hydroxytryptamine (serotonin) receptor 2B / P41595* / 5-hydroxytryptamine receptor 2B*ENSMUSG0000002622823
Htr2c / P34968 / 5-hydroxytryptamine (serotonin) receptor 2C / P28335* / 5-hydroxytryptamine receptor 2C*ENSMUSG0000004138023
Htr2a / P35363 / 5-hydroxytryptamine (serotonin) receptor 2A / P28223* / 5-hydroxytryptamine receptor 2A*ENSMUSG0000003499723
Drd4 / P51436 / D(4) dopamine receptor / P21917* / dopamine receptor D4*ENSMUSG0000002549622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000507  Beta 1 adrenoceptor
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IMP
 biological_processGO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine IMP
 biological_processGO:0002024 diet induced thermogenesis IGI
 biological_processGO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0009409 response to cold IGI
 biological_processGO:0030819 obsolete positive regulation of cAMP biosynthetic process IEA
 biological_processGO:0031649 heat generation IGI
 biological_processGO:0040015 negative regulation of multicellular organism growth IGI
 biological_processGO:0042596 fear response IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0045823 positive regulation of heart contraction IEA
 biological_processGO:0050873 brown fat cell differentiation IGI
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IMP
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IEA
 molecular_functionGO:0004940 beta1-adrenergic receptor activity IMP
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0031694 alpha-2A adrenergic receptor binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051379 epinephrine binding IBA
 molecular_functionGO:0051380 norepinephrine binding IBA


Pathways (from Reactome)
Pathway description
Adrenoceptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0009119 increased brown fat cell size "increase in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0009294 increased interscapular fat pad weight 
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Adrb1tm1Bkk/Adrb1tm1Bkk,Adrb2tm1Bkk/Adrb2tm1Bkk,Adrb3tm1Lowl/Adrb3tm1Lowl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * FVB/N

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Adrb3tm1Jpg/Adrb3tm1Jpg
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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