ENSG00000043591


Homo sapiens

Features
Gene ID: ENSG00000043591
  
Biological name :ADRB1
  
Synonyms : ADRB1 / adrenoceptor beta 1 / P08588
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q25.3
Gene start: 114044056
Gene end: 114046908
  
Corresponding Affymetrix probe sets: 208214_at (Human Genome U133 Plus 2.0 Array)   229277_at (Human Genome U133 Plus 2.0 Array)   229309_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000358301
NCBI entrez gene - 153     See in Manteia.
OMIM - 109630
RefSeq - NM_000684
RefSeq Peptide - NP_000675
swissprot - P08588
Ensembl - ENSG00000043591
  
Related genetic diseases (OMIM): 109630 - {Congestive heart failure and beta-blocker response, modifier of}
  607276 - [Resting heart rate], 607276
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adrb1ENSDARG00000007490Danio rerio
 ADRB1ENSGALG00000008949Gallus gallus
 Adrb1ENSMUSG00000035283Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADRB3 / P13945 / adrenoceptor beta 3ENSG0000018877843
ADRB2 / P07550 / adrenoceptor beta 2ENSG0000016925243
DRD1 / P21728 / dopamine receptor D1ENSG0000018484529
DRD5 / P21918 / dopamine receptor D5ENSG0000016967629
HTR6 / P50406 / 5-hydroxytryptamine receptor 6ENSG0000015874828
HRH2 / P25021 / histamine receptor H2ENSG0000011374925
DRD3 / P35462 / dopamine receptor D3ENSG0000015157724
HTR2A / P28223 / 5-hydroxytryptamine receptor 2AENSG0000010246823
DRD2 / P14416 / dopamine receptor D2ENSG0000014929523
DRD4 / P21917 / dopamine receptor D4ENSG0000006969623
HTR2C / P28335 / 5-hydroxytryptamine receptor 2CENSG0000014724623
HTR2B / P41595 / 5-hydroxytryptamine receptor 2BENSG0000013591422


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000507  Beta 1 adrenoceptor
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IBA
 biological_processGO:0001996 positive regulation of heart rate by epinephrine-norepinephrine IEA
 biological_processGO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA
 biological_processGO:0002024 diet induced thermogenesis IEA
 biological_processGO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007190 activation of adenylate cyclase activity TAS
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0030819 obsolete positive regulation of cAMP biosynthetic process IDA
 biological_processGO:0031649 heat generation IEA
 biological_processGO:0040015 negative regulation of multicellular organism growth IEA
 biological_processGO:0042596 fear response IEA
 biological_processGO:0043547 positive regulation of GTPase activity IDA
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IDA
 biological_processGO:0045823 positive regulation of heart contraction IEA
 biological_processGO:0050873 brown fat cell differentiation IEA
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IEA
 molecular_functionGO:0004939 beta-adrenergic receptor activity TAS
 molecular_functionGO:0004940 beta1-adrenergic receptor activity TAS
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IDA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0031694 alpha-2A adrenergic receptor binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0051379 epinephrine binding IBA
 molecular_functionGO:0051380 norepinephrine binding IBA


Pathways (from Reactome)
Pathway description
Adrenoceptors
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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