ENSG00000135914


Homo sapiens

Features
Gene ID: ENSG00000135914
  
Biological name :HTR2B
  
Synonyms : 5-hydroxytryptamine receptor 2B / HTR2B / P41595
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q37.1
Gene start: 231108230
Gene end: 231125118
  
Corresponding Affymetrix probe sets: 206638_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000258400
NCBI entrez gene - 3357     See in Manteia.
OMIM - 601122
RefSeq - XM_006712482
RefSeq - NM_000867
RefSeq - NM_001320758
RefSeq - XM_005246520
RefSeq Peptide - NP_000858
RefSeq Peptide - NP_001307687
swissprot - P41595
Ensembl - ENSG00000135914
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 htr2bENSDARG00000115925Danio rerio
 HTR2BENSGALG00000007681Gallus gallus
 Htr2bENSMUSG00000026228Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HTR2A / P28223 / 5-hydroxytryptamine receptor 2AENSG0000010246843
HTR2C / P28335 / 5-hydroxytryptamine receptor 2CENSG0000014724641
DRD1 / P21728 / dopamine receptor D1ENSG0000018484524
DRD2 / P14416 / dopamine receptor D2ENSG0000014929523
DRD5 / P21918 / dopamine receptor D5ENSG0000016967623
DRD4 / P21917 / dopamine receptor D4ENSG0000006969623
HTR6 / P50406 / 5-hydroxytryptamine receptor 6ENSG0000015874822
ADRB1 / P08588 / adrenoceptor beta 1ENSG0000004359121
ADRB2 / P07550 / adrenoceptor beta 2ENSG0000016925221
ADRB3 / P13945 / adrenoceptor beta 3ENSG0000018877821
DRD3 / P35462 / dopamine receptor D3ENSG0000015157721
HRH2 / P25021 / histamine receptor H2ENSG0000011374918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000482  5-Hydroxytryptamine 2B receptor
 IPR002231  5-hydroxytryptamine receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0001819 positive regulation of cytokine production IDA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002031 G-protein coupled receptor internalization IEA
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0003300 cardiac muscle hypertrophy IEA
 biological_processGO:0006182 cGMP biosynthetic process IDA
 biological_processGO:0006874 cellular calcium ion homeostasis IDA
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007202 activation of phospholipase C activity IDA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007210 serotonin receptor signaling pathway IMP
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007610 behavior IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0010513 positive regulation of phosphatidylinositol biosynthetic process IDA
 biological_processGO:0014033 neural crest cell differentiation IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0014827 intestine smooth muscle contraction IMP
 biological_processGO:0016310 phosphorylation IMP
 biological_processGO:0019722 calcium-mediated signaling IMP
 biological_processGO:0042310 vasoconstriction IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
 biological_processGO:0043406 positive regulation of MAP kinase activity IDA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048598 embryonic morphogenesis IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0050795 regulation of behavior IMP
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IDA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IMP
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060548 negative regulation of cell death IMP
 biological_processGO:0070371 ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0070528 protein kinase C signaling IMP
 biological_processGO:0071502 cellular response to temperature stimulus IEA
 biological_processGO:0098664 G-protein coupled serotonin receptor signaling pathway IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IMP
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004993 G-protein coupled serotonin receptor activity IDA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0030594 neurotransmitter receptor activity IBA
 molecular_functionGO:0051378 serotonin binding IEA


Pathways (from Reactome)
Pathway description
Serotonin receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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