ENSG00000169252


Homo sapiens

Features
Gene ID: ENSG00000169252
  
Biological name :ADRB2
  
Synonyms : ADRB2 / adrenoceptor beta 2 / P07550
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q32
Gene start: 148825245
Gene end: 148828687
  
Corresponding Affymetrix probe sets: 206170_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000305372
RefSeq - NM_000024
RefSeq Peptide - NP_000015
swissprot - P07550
swissprot - X5DQM5
Ensembl - ENSG00000169252
  
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adrb2aENSDARG00000088124Danio rerio
 adrb2bENSDARG00000054510Danio rerio
 ADRB2ENSGALG00000040035Gallus gallus
 Adrb2ENSMUSG00000045730Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ADRB1 / P08588 / adrenoceptor beta 1ENSG0000004359150
ADRB3 / P13945 / adrenoceptor beta 3ENSG0000018877841
DRD1 / P21728 / dopamine receptor D1ENSG0000018484530
DRD5 / P21918 / dopamine receptor D5ENSG0000016967630
HTR2C / P28335 / 5-hydroxytryptamine receptor 2CENSG0000014724626
DRD3 / P35462 / dopamine receptor D3ENSG0000015157725
DRD2 / P14416 / dopamine receptor D2ENSG0000014929525
HTR2B / P41595 / 5-hydroxytryptamine receptor 2BENSG0000013591425
HRH2 / P25021 / histamine receptor H2ENSG0000011374925
HTR6 / P50406 / 5-hydroxytryptamine receptor 6ENSG0000015874825
HTR2A / P28223 / 5-hydroxytryptamine receptor 2AENSG0000010246823
DRD4 / P21917 / dopamine receptor D4ENSG0000006969622


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000332  Beta 2 adrenoceptor
 IPR002233  Adrenoceptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001993 regulation of systemic arterial blood pressure by norepinephrine-epinephrine IEA
 biological_processGO:0002024 diet induced thermogenesis IEA
 biological_processGO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA
 biological_processGO:0002028 regulation of sodium ion transport IEA
 biological_processGO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin IDA
 biological_processGO:0006898 receptor-mediated endocytosis IDA
 biological_processGO:0006940 regulation of smooth muscle contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007190 activation of adenylate cyclase activity IDA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0008333 endosome to lysosome transport TAS
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0010739 positive regulation of protein kinase A signaling IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IMP
 biological_processGO:0031649 heat generation IEA
 biological_processGO:0040015 negative regulation of multicellular organism growth IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0045453 bone resorption IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045986 negative regulation of smooth muscle contraction IEA
 biological_processGO:0050873 brown fat cell differentiation IEA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0061885 positive regulation of mini excitatory postsynaptic potential IEA
 biological_processGO:0071875 adrenergic receptor signaling pathway IDA
 biological_processGO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IGI
 biological_processGO:0097746 regulation of blood vessel diameter IEA
 biological_processGO:1901098 positive regulation of autophagosome maturation IDA
 biological_processGO:1904504 positive regulation of lipophagy IDA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:1990911 response to psychosocial stress TAS
 biological_processGO:2000481 positive regulation of cAMP-dependent protein kinase activity TAS
 biological_processGO:2000969 positive regulation of AMPA receptor activity IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005764 lysosome TAS
 cellular_componentGO:0005768 endosome TAS
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0016020 membrane NAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane TAS
 cellular_componentGO:0043235 receptor complex IDA
 molecular_functionGO:0001540 amyloid-beta binding IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004935 adrenergic receptor activity IEA
 molecular_functionGO:0004941 beta2-adrenergic receptor activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008179 adenylate cyclase binding IEA
 molecular_functionGO:0015459 potassium channel regulator activity IDA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0044877 protein-containing complex binding IPI
 molecular_functionGO:0051379 epinephrine binding IBA
 molecular_functionGO:0051380 norepinephrine binding IDA


Pathways (from Reactome)
Pathway description
Adrenoceptors
G alpha (s) signalling events
Ub-specific processing proteases
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000198055 GRK6 / P43250 / G protein-coupled receptor kinase 6  / reaction / complex
 ENSG00000141480 ARRB2 / P32121 / arrestin beta 2  / complex / reaction
 ENSG00000198873 GRK5 / P34947 / G protein-coupled receptor kinase 5  / reaction / complex
 ENSG00000173020 GRK2 / P25098 / G protein-coupled receptor kinase 2  / complex / reaction
 ENSG00000100077 GRK3 / P35626 / G protein-coupled receptor kinase 3  / reaction / complex
 ENSG00000137486 ARRB1 / P49407 / arrestin beta 1  / complex / reaction
 ENSG00000136878 USP20 / Q9Y2K6 / ubiquitin specific peptidase 20  / complex
 ENSG00000077254 USP33 / Q8TEY7 / ubiquitin specific peptidase 33  / complex






 

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