ENSG00000077254


Homo sapiens

Features
Gene ID: ENSG00000077254
  
Biological name :USP33
  
Synonyms : Q8TEY7 / ubiquitin specific peptidase 33 / USP33
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p31.1
Gene start: 77695987
Gene end: 77759852
  
Corresponding Affymetrix probe sets: 212513_s_at (Human Genome U133 Plus 2.0 Array)   214843_s_at (Human Genome U133 Plus 2.0 Array)   217441_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432667
Ensembl peptide - ENSP00000432392
Ensembl peptide - ENSP00000433283
Ensembl peptide - ENSP00000436441
Ensembl peptide - ENSP00000434441
Ensembl peptide - ENSP00000350009
Ensembl peptide - ENSP00000359828
Ensembl peptide - ENSP00000359829
Ensembl peptide - ENSP00000359830
NCBI entrez gene - 23032     See in Manteia.
OMIM - 615146
RefSeq - XM_017000729
RefSeq - XM_011541055
RefSeq - XM_011541056
RefSeq - XM_017000722
RefSeq - XM_017000723
RefSeq - XM_017000724
RefSeq - XM_017000725
RefSeq - XM_017000726
RefSeq - XM_017000727
RefSeq - XM_017000728
RefSeq - NM_015017
RefSeq - NM_201624
RefSeq - NM_201626
RefSeq - XM_005270648
RefSeq - XM_005270649
RefSeq Peptide - NP_963918
RefSeq Peptide - NP_963920
RefSeq Peptide - NP_055832
swissprot - H0YD08
swissprot - E9PQP0
swissprot - Q8TEY7
swissprot - E9PLK7
swissprot - E9PP47
swissprot - H0YCV3
Ensembl - ENSG00000077254
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp33ENSDARG00000016163Danio rerio
 USP33ENSGALG00000008974Gallus gallus
 Usp33ENSMUSG00000025437Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP20 / Q9Y2K6 / ubiquitin specific peptidase 20ENSG0000013687858
USP8 / P40818 / ubiquitin specific peptidase 8ENSG0000013859216
USP16 / Q9Y5T5 / ubiquitin specific peptidase 16ENSG0000015625616
USP2 / O75604 / ubiquitin specific peptidase 2ENSG0000003667215
USP45 / Q70EL2 / ubiquitin specific peptidase 45ENSG0000012355215
USP21 / Q9UK80 / ubiquitin specific peptidase 21ENSG0000014325814
USP50 / Q70EL3 / ubiquitin specific peptidase 50ENSG0000017023610


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001607  Zinc finger, UBP-type
 IPR006615  Peptidase C19, ubiquitin-specific peptidase, DUSP domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain
 IPR035927  DUSP-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007411 axon guidance ISS
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IMP
 biological_processGO:0009267 cellular response to starvation IDA
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0016579 protein deubiquitination IMP
 biological_processGO:0032091 negative regulation of protein binding IMP
 biological_processGO:0032092 positive regulation of protein binding IMP
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051298 centrosome duplication IMP
 biological_processGO:0070536 protein K63-linked deubiquitination IDA
 biological_processGO:0071108 protein K48-linked deubiquitination IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005776 autophagosome IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0030891 VCB complex TAS
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IPI
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IMP
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017160 Ral GTPase binding IPI
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Ub-specific processing proteases
Regulation of expression of SLITs and ROBOs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000103540 CCP110 / O43303 / centriolar coiled-coil protein 110  / complex
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / reaction
 ENSG00000169252 ADRB2 / P07550 / adrenoceptor beta 2  / complex
 ENSG00000141480 ARRB2 / P32121 / arrestin beta 2  / complex






 

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