ENSG00000143258


Homo sapiens

Features
Gene ID: ENSG00000143258
  
Biological name :USP21
  
Synonyms : Q9UK80 / ubiquitin specific peptidase 21 / USP21
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q23.3
Gene start: 161159450
Gene end: 161165723
  
Corresponding Affymetrix probe sets: 218367_x_at (Human Genome U133 Plus 2.0 Array)   232219_x_at (Human Genome U133 Plus 2.0 Array)   234735_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000476830
Ensembl peptide - ENSP00000476344
Ensembl peptide - ENSP00000491514
Ensembl peptide - ENSP00000492693
Ensembl peptide - ENSP00000289865
Ensembl peptide - ENSP00000356980
Ensembl peptide - ENSP00000356981
NCBI entrez gene - 27005     See in Manteia.
OMIM - 604729
RefSeq - XM_017001042
RefSeq - NM_012475
RefSeq - XM_011509414
RefSeq - XM_017001036
RefSeq - XM_017001037
RefSeq - XM_017001038
RefSeq - XM_017001039
RefSeq - XM_017001040
RefSeq - XM_017001041
RefSeq - NM_001014443
RefSeq - NM_001319848
RefSeq Peptide - NP_001306777
RefSeq Peptide - NP_036607
RefSeq Peptide - NP_001014443
swissprot - A0A1W2PQ32
swissprot - A0A1W2PRX0
swissprot - Q9UK80
swissprot - V9GY36
swissprot - V9GYJ6
Ensembl - ENSG00000143258
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp21ENSDARG00000094280Danio rerio
 Usp21ENSMUSG00000053483Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP2 / O75604 / ubiquitin specific peptidase 2ENSG0000003667239
USP8 / P40818 / ubiquitin specific peptidase 8ENSG0000013859229
USP20 / Q9Y2K6 / ubiquitin specific peptidase 20ENSG0000013687823
USP33 / Q8TEY7 / ubiquitin specific peptidase 33ENSG0000007725423
USP16 / Q9Y5T5 / ubiquitin specific peptidase 16ENSG0000015625620
USP45 / Q70EL2 / ubiquitin specific peptidase 45ENSG0000012355220
USP50 / Q70EL3 / ubiquitin specific peptidase 50ENSG0000017023617


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0016578 histone deubiquitination ISS
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0003713 transcription coactivator activity ISS
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019784 NEDD8-specific protease activity IDA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000137033 IL33 / O95760 / interleukin 33  / complex
 ENSG00000107485 GATA3 / P23771 / GATA binding protein 3  / complex
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / complex
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / complex






 

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