ENSG00000036672


Homo sapiens

Features
Gene ID: ENSG00000036672
  
Biological name :USP2
  
Synonyms : O75604 / ubiquitin specific peptidase 2 / USP2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q23.3
Gene start: 119355215
Gene end: 119381726
  
Corresponding Affymetrix probe sets: 207211_at (Human Genome U133 Plus 2.0 Array)   207213_s_at (Human Genome U133 Plus 2.0 Array)   229337_at (Human Genome U133 Plus 2.0 Array)   230965_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436952
Ensembl peptide - ENSP00000407842
Ensembl peptide - ENSP00000431857
Ensembl peptide - ENSP00000433977
Ensembl peptide - ENSP00000260187
NCBI entrez gene - 9099     See in Manteia.
OMIM - 604725
RefSeq - XM_017018539
RefSeq - NM_001243759
RefSeq - NM_004205
RefSeq - NM_171997
RefSeq - XM_005271721
RefSeq - XM_005271722
RefSeq Peptide - NP_004196
RefSeq Peptide - NP_741994
RefSeq Peptide - NP_001230688
swissprot - E9PSH6
swissprot - O75604
swissprot - E9PJ34
Ensembl - ENSG00000036672
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp2aENSDARG00000020107Danio rerio
 usp2bENSDARG00000074120Danio rerio
 USP2ENSGALG00000006755Gallus gallus
 Usp2ENSMUSG00000032010Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP21 / Q9UK80 / ubiquitin specific peptidase 21ENSG0000014325837
USP8 / P40818 / ubiquitin specific peptidase 8ENSG0000013859232
USP33 / Q8TEY7 / ubiquitin specific peptidase 33ENSG0000007725424
USP20 / Q9Y2K6 / ubiquitin specific peptidase 20ENSG0000013687822
USP45 / Q70EL2 / ubiquitin specific peptidase 45ENSG0000012355221
USP16 / Q9Y5T5 / ubiquitin specific peptidase 16ENSG0000015625621
USP50 / Q70EL3 / ubiquitin specific peptidase 50ENSG0000017023619


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0043153 entrainment of circadian clock by photoperiod ISS
 biological_processGO:0045475 locomotor rhythm ISS
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048512 circadian behavior ISS
 biological_processGO:0050821 protein stabilization IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity TAS
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030332 cyclin binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135679 MDM2 / Q00987 / MDM2 proto-oncogene  / complex / reaction
 ENSG00000198625 MDM4 / O15151 / MDM4, p53 regulator  / complex / reaction






 

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