ENSG00000198625


Homo sapiens

Features
Gene ID: ENSG00000198625
  
Biological name :MDM4
  
Synonyms : MDM4 / MDM4, p53 regulator / O15151
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.1
Gene start: 204516379
Gene end: 204558120
  
Corresponding Affymetrix probe sets: 205655_at (Human Genome U133 Plus 2.0 Array)   225740_x_at (Human Genome U133 Plus 2.0 Array)   225742_at (Human Genome U133 Plus 2.0 Array)   235162_at (Human Genome U133 Plus 2.0 Array)   236814_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000443816
Ensembl peptide - ENSP00000396840
Ensembl peptide - ENSP00000478080
Ensembl peptide - ENSP00000482479
Ensembl peptide - ENSP00000482388
Ensembl peptide - ENSP00000478581
Ensembl peptide - ENSP00000356147
Ensembl peptide - ENSP00000356148
Ensembl peptide - ENSP00000356150
Ensembl peptide - ENSP00000356151
Ensembl peptide - ENSP00000375811
Ensembl peptide - ENSP00000395254
NCBI entrez gene - 4194     See in Manteia.
OMIM - 602704
RefSeq - NM_001278516
RefSeq - NM_001204171
RefSeq - NM_001204172
RefSeq - NM_001278517
RefSeq - NM_001278518
RefSeq - NM_001278519
RefSeq - NM_002393
RefSeq - XM_017001311
RefSeq - XM_017001312
RefSeq - XM_017001313
RefSeq Peptide - NP_001265445
RefSeq Peptide - NP_001265446
RefSeq Peptide - NP_001265447
RefSeq Peptide - NP_001265448
RefSeq Peptide - NP_002384
RefSeq Peptide - NP_001191100
RefSeq Peptide - NP_001191101
swissprot - Q5T0Y3
swissprot - Q5T0Y4
swissprot - Q6MZR7
swissprot - Q68DC0
swissprot - A0A087WZ58
swissprot - A0A087WUE3
swissprot - A0A087WTR9
swissprot - O15151
swissprot - Q5T0Y2
swissprot - A0A024R990
Ensembl - ENSG00000198625
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mdm4ENSDARG00000057513Danio rerio
 MDM4ENSGALG00000000636Gallus gallus
 Mdm4ENSMUSG00000054387Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MDM2 / Q00987 / MDM2 proto-oncogeneENSG0000013567923


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR001876  Zinc finger, RanBP2-type
 IPR003121  SWIB/MDM2 domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015458  MDM4
 IPR016495  p53 negative regulator Mdm2/Mdm4
 IPR036443  Zinc finger, RanBP2-type superfamily
 IPR036885  SWIB/MDM2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0008283 cell proliferation IEP
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030330 DNA damage response, signal transduction by p53 class mediator IEP
 biological_processGO:0042177 negative regulation of protein catabolic process IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045023 G0 to G1 transition IEP
 biological_processGO:0050821 protein stabilization IEP
 biological_processGO:0065003 protein-containing complex assembly IDA
 biological_processGO:0071157 negative regulation of cell cycle arrest IEA
 biological_processGO:0071456 cellular response to hypoxia IEP
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity TAS


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
Ub-specific processing proteases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Stabilization of p53


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000147889 CDKN2A / P42771 / Q8N726 / cyclin dependent kinase inhibitor 2A  / complex / reaction
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction
 ENSG00000183765 CHEK2 / O96017 / checkpoint kinase 2  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex
 ENSG00000135679 MDM2 / Q00987 / MDM2 proto-oncogene  / complex / reaction
 ENSG00000036672 USP2 / O75604 / ubiquitin specific peptidase 2  / complex / reaction






 

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