ENSDARG00000057513


Danio rerio

Features
Gene ID: ENSDARG00000057513
  
Biological name :mdm4
  
Synonyms : mdm4 / MDM4, p53 regulator
  
Possible biological names infered from orthology : O15151 / O35618 / transformed mouse 3T3 cell double minute 4
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 22890997
Gene end: 22916641
  
Corresponding Affymetrix probe sets: Dr.20062.1.S1_at (Zebrafish Array)   NM_212732_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000128053
Ensembl peptide - ENSDARP00000074651
NCBI entrez gene - 334932     See in Manteia.
RefSeq - NM_212732
RefSeq - XM_005172871
RefSeq - XM_005172869
RefSeq - NM_001328581
RefSeq Peptide - NP_001315510
RefSeq Peptide - NP_997897
swissprot - X1WCV6
swissprot - F1QD25
ZFIN ID - ZDB-GENE-030131-6872
Ensembl - ENSDARG00000057513
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MDM4ENSGALG00000000636Gallus gallus
 MDM4ENSG00000198625Homo sapiens
 Mdm4ENSMUSG00000054387Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mdm2 / MDM2 oncogene, E3 ubiquitin protein ligase / P23804* / Q00987* / MDM2 proto-oncogene* / E3 ubiquitin-protein ligase Mdm2 *ENSDARG0000003344322


Protein motifs (from Interpro)
Interpro ID Name
 IPR001876  Zinc finger, RanBP2-type
 IPR003121  SWIB/MDM2 domain
 IPR015458  MDM4
 IPR016495  p53 negative regulator Mdm2/Mdm4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0071157 negative regulation of cell cycle arrest IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
Ub-specific processing proteases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Stabilization of p53


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000002385 atm / ATM serine/threonine kinase / Q13315* / Q62388* / Serine-protein kinase ATM *  / reaction
 ENSDARG00000035559 tp53 / P79734 / tumor protein p53 / Trp53* / P04637* / P02340* / transformation related protein 53*  / complex / reaction
 ENSDARG00000033443 mdm2 / MDM2 oncogene, E3 ubiquitin protein ligase / P23804* / Q00987* / MDM2 proto-oncogene* / E3 ubiquitin-protein ligase Mdm2 *  / complex / reaction
 ENSDARG00000037262 cdkn2a/b / cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4) / CDKN2A* / CDKN2B* / P42772* / P55271* / Q8N726* / P42771* / cyclin dependent kinase inhibitor 2A* / cyclin dependent...  / reaction / complex






 

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