| MP:0000111 | cleft palate | "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Mdm4tm1Glo/Mdm4+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL * C57BL/6 * SJL
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| MP:0000218 | increased WBC count | "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cd3etm1Cpt/Cd3etm1Cpt,Tg(CD3E)26Cpt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
|
| MP:0000221 | decreased WBC count | "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0000267 | abnormal cardiac development | "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370] |
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Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy
Genetic Background: involves: 129 * C57BL/6
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| MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J
|
| MP:0000280 | thin ventricular wall | "decreased depth of the cardiac wall of the heart ventricles" [J:45302] |
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J
|
| MP:0000333 | decreased bone marrow cell number | "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Mdm4tm1Glo/Mdm4tm1Glo
Genetic Background: Not Specified
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Mdm4tm1Glo/Mdm4+,Trp53tm1.1Tldo/Trp53+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
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| MP:0000352 | decreased cell proliferation | "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Genetic Background: involves: 129S5/SvEvBrd
Allelic Composition: Mdm4tm1Glo/Mdm4tm1Glo
Genetic Background: Not Specified
Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy
Genetic Background: involves: 129 * C57BL/6
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| MP:0000575 | dark foot pads | "darker color of the foot pads due to excess pigment" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Mdm4tm1Glo/Mdm4+
Genetic Background: Not Specified
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm2.1Glo/Mdm4+
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0000585 | kinked tail | "a sharp bend or zig-zag in the tail" [J:61295] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
|
| MP:0000599 | enlarged liver | "larger than average size of the liver" [J:65146] |
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Allelic Composition: Ightm1(Myc)Janz/Igh+,Mdm4tm1.1Wahl/Mdm4tm1.1Wahl
Genetic Background: involves: 129S/Sv * C57BL/6
|
| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ightm1(Myc)Janz/Igh+,Mdm4tm1.1Wahl/Mdm4tm1.1Wahl
Genetic Background: involves: 129S/Sv * C57BL/6
|
| MP:0000694 | spleen hypoplasia | "small size due to reduced cell number in the spleen" [J:43971] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
|
| MP:0000702 | enlarged lymph nodes | "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ightm1(Myc)Janz/Igh+,Mdm4tm1.1Wahl/Mdm4tm1.1Wahl
Genetic Background: involves: 129S/Sv * C57BL/6
|
| MP:0000785 | telencephalon hypoplasia | "reduced cell number in cerebral cortex and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302] |
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Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Genetic Background: involves: 129S5/SvEvBrd
|
| MP:0000825 | dilated lateral ventricles | "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857] |
Show
Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Genetic Background: involves: 129S5/SvEvBrd
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| MP:0000851 | cerebellum hypoplasia | "reduced cell number in the cerebellum" [MGI:CLS, J:45302] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0000852 | small cerebellum | "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S7/SvEvBrd
|
| MP:0000872 | abnormal external granule cell layer | "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0000877 | abnormal Purkinje cell | "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
Show
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
|
| MP:0000886 | abnormal cerebellar granule layer | "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
Show
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0000914 | exencephaly | "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
Show
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
|
| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
Show
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
Show
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0001661 | extended life span | "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6J
Allelic Composition: Mdm4tm2Glo/Mdm4tm2.1Glo,Tg(Myh6-cre)2182Mds/0,Trp53tm1Tyj/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0001672 | abnormal embryogenesis/ development | "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S7/SvEvBrd
Allelic Composition: Mdm4tm1Glo/Mdm4tm1Glo,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas
Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1.1Xlu/Trp53tm1.1Xlu
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N
|
| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
Show
Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Genetic Background: involves: 129S5/SvEvBrd
Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy
Genetic Background: involves: 129 * C57BL/6
|
| MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
Show
Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J
|
| MP:0001823 | thymus hypoplasia | "small size due to reduced cell number in the thymus" [J:23255] |
Show
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0002020 | increased tumor incidence | "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193] |
Show
Allelic Composition: Mdm4tm2Glo/Mdm4tm2.1Glo,Tg(Myh6-cre)2182Mds/0,Trp53tm1Tyj/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0002023 | B cell derived lymphoma | "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ightm1(Myc)Janz/Igh+,Mdm4tm1.1Wahl/Mdm4tm1.1Wahl
Genetic Background: involves: 129S/Sv * C57BL/6
Allelic Composition: Mdm4tm1Glo/Mdm4+,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL * C57BL/6 * SJL
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J
Allelic Composition: Ightm1(Myc)Janz/Igh+,Mdm4tm1.1Wahl/Mdm4tm1.1Wahl
Genetic Background: involves: 129S/Sv * C57BL/6
Allelic Composition: Mdm4tm1Glo/Mdm4+,Trp53tm1.1Tldo/Trp53+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
Allelic Composition: Mdm4tm2Glo/Mdm4tm2.1Glo,Tg(Myh6-cre)2182Mds/0,Trp53tm1Tyj/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6J * FVB/N
|
| MP:0002123 | abnormal hematopoiesis | "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Galnstm2(GALNS)Toma/Galnstm2(GALNS)Toma
Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Mdm4tm3Glo/Mdm4tm3.1Glo,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N
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| MP:0002795 | dilated cardiomyopathy | "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J
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| MP:0002874 | decreased hemoglobin content | "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0003010 | decreased mortality induced by ionizing radiation | "reduced sensitivity to lethal doses of ionizing radiation such as ultraviolet light, X-rays, or gamma rays" [smb:Susan M. Bello , Mouse Genome Informatics Curator, J:88888] |
Show
Allelic Composition: Cd3etm1Cpt/Cd3etm1Cpt,Tg(CD3E)26Cpt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0003077 | abnormal cell cycle | "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266] |
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Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex,Trp53tm3Wahl/Trp53tm3Wahl
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm3Wahl/Trp53tm3Wahl
Genetic Background: involves: 129
Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Genetic Background: involves: 129S5/SvEvBrd
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| MP:0003131 | increased erythrocyte count | "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Cd3etm1Cpt/Cd3etm1Cpt,Tg(CD3E)26Cpt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0003141 | cardiac fibrosis | "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J
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| MP:0003155 | abnormal telomere length | "abnormal length of the terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability; normal length is a few hundred base pairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Mdm4tm1Glo/Mdm4+,Trp53tm1.1Tldo/Trp53+
Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6
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| MP:0003179 | decreased platelet count | "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0003207 | decreased sensitivity to gamma-irradiation | "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cd3etm1Cpt/Cd3etm1Cpt,Tg(CD3E)26Cpt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0003222 | increased cardiomyocyte apoptosis | "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J
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| MP:0003643 | spleen atrophy | "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0003644 | thymus atrophy | "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0003717 | pallor | "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Genetic Background: involves: 129S5/SvEvBrd
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0003720 | abnormal neural tube closure | "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099] |
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Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Genetic Background: involves: 129S5/SvEvBrd
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| MP:0003861 | abnormal nervous system development | "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Genetic Background: involves: 129S5/SvEvBrd
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Mdm4tm1Glo/Mdm4tm1Glo,Trp53tm1Adv/Trp53tm1Adv
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1.1Xlu/Trp53tm1.1Xlu
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N
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| MP:0003992 | increased mortality induced by ionizing radiation | "greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Grin2ctm2Rsp/Grin2ctm2Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Mdm4tm1Glo/Mdm4+
Genetic Background: Not Specified
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| MP:0004045 | abnormal cell cycle checkpoint function | "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Genetic Background: involves: 129S5/SvEvBrd
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| MP:0004200 | reduced fetal size | "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0004261 | abnormal embryonic neuroepithelium morphology | "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy
Genetic Background: involves: 129 * C57BL/6
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| MP:0004505 | decreased renal glomerulus number | "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0004564 | enlarged myocardial fiber | "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J
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| MP:0004567 | decreased myocardial fiber number | "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J
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| MP:0005152 | pancytopenia | "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0005505 | increased platelet count | "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cd3etm1Cpt/Cd3etm1Cpt,Tg(CD3E)26Cpt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0005621 | abnormal cell physiology | "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Grin2ctm2Rsp/Grin2ctm2Rsp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0006138 | congestive heart failure | "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J
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| MP:0006386 | absent somites | "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy
Genetic Background: involves: 129 * C57BL/6
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| MP:0008022 | dilated heart ventricles | "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mdm4tm2.1Glo/Mdm4tm2.1Glo,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J
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| MP:0008411 | decreased cellular sensitivity to ultraviolet irradiation | "reduced incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd
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| MP:0008924 | decreased granule neuron number | "reduction in the number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S7/SvEvBrd
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| MP:0009336 | increased splenocyte proliferation | "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ightm1(Myc)Janz/Igh+,Mdm4tm1.1Wahl/Mdm4tm1.1Wahl
Genetic Background: involves: 129S/Sv * C57BL/6
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| MP:0009542 | decreased thymocyte apoptosis | "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd3etm1Cpt/Cd3etm1Cpt,Tg(CD3E)26Cpt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Galnstm2(GALNS)Toma/Galnstm2(GALNS)Toma
Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Mdm4tm1Glo/Mdm4+,Rpl27aSfa/Rpl27a+
Genetic Background: involves: C57BL/6J
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| MP:0011096 | complete embryonic lethality before somite formation | "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith] |
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Allelic Composition: Mdm4tm1Glo/Mdm4tm1Glo
Genetic Background: Not Specified
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Genetic Background: involves: 129S5/SvEvBrd
Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Mdm4tm3.1Glo/Mdm4tm3.1Glo
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
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| MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd
Allelic Composition: Mdm4tm1Glo/Mdm4tm1Glo,Trp53tm1Adv/Trp53tm1Adv
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Mdm4tm1Glo/Mdm4tm1Glo,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
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| MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex,Trp53tm1.1Xlu/Trp53tm1.1Xlu
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1.1Xlu/Trp53tm1.1Xlu
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex
Genetic Background: involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6 * FVB/N
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| MP:0011703 | increased fibroblast proliferation | "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith] |
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Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd
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| MP:0011704 | decreased fibroblast proliferation | "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith] |
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Allelic Composition: Mdm4Gt(VICTR20)7Lex/Mdm4Gt(VICTR20)7Lex,Trp53tm3Wahl/Trp53tm3Wahl
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd
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| MP:0012431 | increased lymphoma incidence | "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith] |
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Allelic Composition: Ightm1(Myc)Janz/Igh+,Mdm4tm1.1Wahl/Mdm4tm1.1Wahl
Genetic Background: involves: 129S/Sv * C57BL/6
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| MP:0013504 | increased embryonic tissue cell apoptosis | "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith] |
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4tm1Glo/Mdm4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Allelic Composition: Mdm4tm1Zmy/Mdm4tm1Zmy
Genetic Background: involves: 129 * C57BL/6
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