ENSMUSG00000034218


Mus musculus

Features
Gene ID: ENSMUSG00000034218
  
Biological name :Atm
  
Synonyms : Atm / Q62388 / Serine-protein kinase ATM
  
Possible biological names infered from orthology : ATM serine/threonine kinase / Q13315
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.3
Gene start: 53439149
Gene end: 53536740
  
Corresponding Affymetrix probe sets: 10593526 (MoGene1.0st)   1421205_at (Mouse Genome 430 2.0 Array)   1428830_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118199
Ensembl peptide - ENSMUSP00000113388
Ensembl peptide - ENSMUSP00000115394
NCBI entrez gene - 11920     See in Manteia.
MGI - MGI:107202
RefSeq - XM_006509956
RefSeq - XM_011242385
RefSeq - XM_011242386
RefSeq - NM_007499
RefSeq Peptide - NP_031525
swissprot - Q62388
swissprot - D3Z0Q2
swissprot - F6UXV2
Ensembl - ENSMUSG00000034218
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atmENSDARG00000002385Danio rerio
 ATMENSGALG00000017159Gallus gallus
 ATMENSG00000149311Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic domain
 IPR003151  PIK-related kinase, FAT
 IPR003152  FATC domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR014009  PIK-related kinase
 IPR015519  Serine/threonine-protein kinase ATM
 IPR016024  Armadillo-type fold
 IPR018936  Phosphatidylinositol 3/4-kinase, conserved site
 IPR021668  Telomere-length maintenance and DNA damage repair
 IPR036940  Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0000723 telomere maintenance IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination IMP
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001756 somitogenesis IGI
 biological_processGO:0002331 pre-B cell allelic exclusion IMP
 biological_processGO:0002376 immune system process IMP
 biological_processGO:0002377 immunoglobulin production IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006975 DNA damage induced protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007094 mitotic spindle assembly checkpoint IEA
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0007143 female meiotic nuclear division IMP
 biological_processGO:0007292 female gamete generation IMP
 biological_processGO:0007420 brain development IGI
 biological_processGO:0007507 heart development IGI
 biological_processGO:0008340 determination of adult lifespan IGI
 biological_processGO:0008585 female gonad development IMP
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016572 histone phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0030889 negative regulation of B cell proliferation IEA
 biological_processGO:0032210 regulation of telomere maintenance via telomerase IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0033129 positive regulation of histone phosphorylation IEA
 biological_processGO:0033151 V(D)J recombination IGI
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0036289 peptidyl-serine autophosphorylation IEA
 biological_processGO:0042159 lipoprotein catabolic process IGI
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045141 meiotic telomere clustering IMP
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048538 thymus development IMP
 biological_processGO:0048599 oocyte development IMP
 biological_processGO:0051402 neuron apoptotic process IGI
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0070192 chromosome organization involved in meiotic cell cycle IMP
 biological_processGO:0071044 histone mRNA catabolic process IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0071481 cellular response to X-ray IEA
 biological_processGO:0071500 cellular response to nitrosative stress IEA
 biological_processGO:0072434 signal transduction involved in mitotic G2 DNA damage checkpoint IEA
 biological_processGO:0090399 replicative senescence IEA
 biological_processGO:0097694 establishment of RNA localization to telomere IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1903626 positive regulation of DNA catabolic process IEA
 biological_processGO:1903978 regulation of microglial cell activation IEA
 biological_processGO:1904262 negative regulation of TORC1 signaling IMP
 biological_processGO:1904354 negative regulation of telomere capping IEA
 biological_processGO:1904358 positive regulation of telomere maintenance via telomere lengthening IEA
 biological_processGO:1904884 positive regulation of telomerase catalytic core complex assembly IEA
 biological_processGO:1905843 regulation of cellular response to gamma radiation IEA
 biological_processGO:2001022 positive regulation of response to DNA damage stimulus IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:1990391 DNA repair complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004677 DNA-dependent protein kinase activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
DNA Damage/Telomere Stress Induced Senescence
Regulation of HSF1-mediated heat shock response
Autodegradation of the E3 ubiquitin ligase COP1
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
TP53 Regulates Transcription of Caspase Activators and Caspases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
G2/M DNA damage checkpoint
Stabilization of p53


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000013 abnormal fat distribution "alterations in the normal placement and amount of body fat" [J:57315]
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Allelic Composition: Lrrk2tm2Arte/Lrrk2tm2Arte
Genetic Background: Not Specified

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plcz1em2Jparr/Plcz1em2Jparr
Genetic Background: C57BL/6-Plcz1em2Jparr

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0000711 thymic cortex hypoplasia "reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
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Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0001145 abnormal male reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that produces spermatozoa" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Atmtm1Led/Atmtm1Led,Kat8tm2Thl/Kat8+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad52tm1Aps/Rad52tm1Aps
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: CByJ.129S6-Atmtm1Awb

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: B6.129S6-Atmtm1Awb

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: A.129S6-Atmtm1Awb

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: either: (129S6/SvEvTac-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: either: (129S6/SvEvTac-Atmtm1Awb x A.129S6-Atmtm1Awb)F1 or (A.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: either: (A.129S6-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x A.129S6-Atmtm1Awb)F1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Lig4tm1Icrf/Lig4tm1Icrf
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Lig4tm1Pmc/Lig4tm1Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * SJL

Allelic Composition: Atmtm1.1Mmpl/Atmtm1.1Mmpl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Atmtm1Awb/Atm+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad52tm1Aps/Rad52tm1Aps
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: A.129S6-Atmtm1Awb/J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0001830 decreased activated T cell number "reduced numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pnkptm1.1Pmc/Pnkptm1.1Pmc,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0001931 abnormal oogenesis "atypical formation or failure to form the female germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002019 abnormal tumor incidence "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: B6.129S6-Atmtm1Awb

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: either: (A.129S6-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x A.129S6-Atmtm1Awb)F1

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

Allelic Composition: Atmtm1Mfl/Atm+
Genetic Background: involves: 129T2/SvEms * C57BL/6J

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad52tm1Aps/Rad52tm1Aps
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: CByJ.129S6-Atmtm1Awb

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: either: (129S6/SvEvTac-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: either: (129S6/SvEvTac-Atmtm1Awb x A.129S6-Atmtm1Awb)F1 or (A.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1

Allelic Composition: Atmtm1.1Mmpl/Atmtm1.1Mmpl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Atmtm1Mfl/Atm+
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Atmtm1Mfl/Atm+
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Lig4tm1Pmc/Lig4tm1Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/SvImJ * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Atmtm1Awb/Atm+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Ppm1dtm1Lad/Ppm1dtm1Lad,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129 * C57BL * FVB/N * SJL

Allelic Composition: Atmtm1Led/Atm+,Kat8tm2Thl/Kat8+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Atmtm1Led/Atmtm1Led,Kat8tm2Thl/Kat8+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad52tm1Aps/Rad52tm1Aps
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: CByJ.129S6-Atmtm1Awb

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: B6.129S6-Atmtm1Awb

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: A.129S6-Atmtm1Awb

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: either: (129S6/SvEvTac-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: either: (129S6/SvEvTac-Atmtm1Awb x A.129S6-Atmtm1Awb)F1 or (A.129S6-Atmtm1Awb x 129S6/SvEvTac-Atmtm1Awb)F1

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: either: (A.129S6-Atmtm1Awb x B6.129S6-Atmtm1Awb)F1 or (B6.129S6-Atmtm1Awb x A.129S6-Atmtm1Awb)F1

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: A.129S6-Atmtm1Awb

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Awb/Atm+,Rad50tm4.1Jpt/Rad50+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0002399 abnormal pluripotent precursor cell morphology/development "anomalous structure or fomation of the cells that give rise to most types of cells necessary for fetal development" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,Pknox1tm1Fbla/Pknox1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Pmc/Atmtm1Pmc
Genetic Background: B6.Cg-Atmtm1Pmc

 MP:0003202 abnormal neuron apoptosis "change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm2Pmc/Atmtm2Pmc,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Xrcc2tm1Pmc/Xrcc2tm1Pmc
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Allelic Composition: Atmtm1Pmc/Atm+,Lig4tm1Icrf/Lig4tm1Icrf
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Lig4tm1Icrf/Lig4tm1Icrf
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

 MP:0003207 decreased sensitivity to gamma-irradiation "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Jak3bfy/Jak3bfy
Genetic Background: C57BL/6JSfdAnu-Jak3bfy/AnuApb

Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Trp73tm2Mak/Trp73tm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: A.129S6-Atmtm1Awb

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Atmtm2Pmc/Atmtm2Pmc,Atrtm2Bal/Atrtm2Bal,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac

 MP:0003830 abnormal testis development "abnormal morphogenesis of the male reproductive gland containing the germ cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:100020]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Atmtm1Awb/Atm+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2atm1.1Brn/Cdkn2atm1.1Brn,Pknox1tm1Fbla/Pknox1tm1Fbla
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,Pknox1tm1Fbla/Pknox1tm1Fbla
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Atmtm1Pmc/Atmtm1Pmc
Genetic Background: Not Specified

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0004101 abnormal brain interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atmtm2Pmc/Atmtm2Pmc,Pnkptm1.1Pmc/Pnkptm1.1Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0004228 decreased cellular sensitivity to ionizing radiation "decreased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Nbntm2.1Jpt/Nbntm2.1Jpt
Genetic Background: involves: 129S6/SvEvTac * 129/Sv

Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Lig4tm1Icrf/Lig4tm1Icrf
Genetic Background: involves: 129

Allelic Composition: Atmtm2Pmc/Atmtm2Pmc,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Atmtm2Pmc/Atmtm2Pmc,Atrtm2Bal/Atrtm2Bal,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Atmtm1Shzh/Atmtm2.1Fwa,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S6/SvEvTac

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Paxxem1Spj/Paxxem1Spj
Genetic Background: involves: A/J * C57BL/6NTac

 MP:0004849 abnormal testis size "anomaly in the size of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Awb/Atm+,Rad50tm4.1Jpt/Rad50+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc
Genetic Background: B6.Cg-Atmtm1Pmc

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atmtm1.1Mmpl/Atmtm1.1Mmpl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Terttm1.1Phan/Terttm1.1Phan,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Paxxem1Spj/Paxxem1Spj
Genetic Background: involves: A/J * C57BL/6NTac

Allelic Composition: Atmtm1.1Mmpl/Atmtm1.1Mmpl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lrrk2tm2Arte/Lrrk2tm2Arte
Genetic Background: Not Specified

Allelic Composition: Atmtm1Pmc/Atm+
Genetic Background: B6.Cg-Atmtm1Pmc

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lrrk2tm2Arte/Lrrk2tm2Arte
Genetic Background: Not Specified

Allelic Composition: Atmtm1Pmc/Atm+
Genetic Background: B6.Cg-Atmtm1Pmc

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Lrrk2tm2Arte/Lrrk2tm2Arte
Genetic Background: Not Specified

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Tardbptm2(TARDBP*A382T/Venus)Okn/Tardbp+
Genetic Background: Not Specified

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Mfl/Atm+
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
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Allelic Composition: Atmtm1.1Mmpl/Atmtm1.1Mmpl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad52tm1Aps/Rad52tm1Aps
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad52tm1Aps/Rad52tm1Aps
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Mfl/Atmtm1Mfl
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: 129S6/SvEvTac-Atmtm1Awb/J

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc
Genetic Background: B6.Cg-Atmtm1Pmc

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
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Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Atmtm1Shzh/Atmtm2.1Fwa
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Atmtm1Shzh/Atmtm2.1Fwa,Gt(ROSA)26Sortm1(cre/ERT2)Thl/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S6/SvEvTac

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1.1Mmpl/Atmtm1.1Mmpl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0009021 absent estrus "absence or failure of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Fwa/Atmtm1Fwa
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Paxxem1Spj/Paxxem1Spj
Genetic Background: involves: A/J * C57BL/6NTac

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Trp73tm2Mak/Trp73tm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Atmtm1Awb/Atm+,Rad50tm4.1Jpt/Rad50+
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

 MP:0010268 decreased lymphoma incidence "less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad52tm1Aps/Rad52tm1Aps
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
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Allelic Composition: Atmtm1Mfl/Atm+
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: B6.129S6-Atmtm1Awb

Allelic Composition: Atmtm1Awb/Atmtm1Awb
Genetic Background: A.129S6-Atmtm1Awb

Allelic Composition: Atmtm1.1Mmpl/Atmtm1.1Mmpl
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Lig4tm1Icrf/Lig4tm1Icrf
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Nbntm1Jpt/Nbntm1Jpt,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd

Allelic Composition: Atmtm1.1Shzh/Atmtm1.1Shzh
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Lig4tm1Icrf/Lig4tm1Icrf
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129S1/Sv * 129X1/SvJ)

Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,Pknox1tm1Fbla/Pknox1tm1Fbla
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011168 abnormal fat cell differentiation "abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449, MGI:csmith]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc
Genetic Background: B6.Cg-Atmtm1Pmc

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Apaf1tm1Mak/Apaf1tm1Mak
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc
Genetic Background: B6.Cg-Atmtm1Pmc

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Atmtm1Awb/Atmtm1Awb,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Atmtm1Awb/Atm+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Atmtm1Mfl/Atm+
Genetic Background: involves: 129T2/SvEms * C57BL/6J

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Atmtm1Fwa/Atmtm1Fwa,H2afxtm1Fwa/H2afxtm1Fwa
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0013236 ovary degeneration "a retrogressive impairment of function or destruction of one or both ovaries" [MGI:anna]
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Allelic Composition: Atmtm1Bal/Atmtm1Bal
Genetic Background: involves: 129S4/SvJae

 MP:0014127 increased thymoma incidence "greater than the expected number of a malignant neoplasm originating from the epithelial cells of the thymus, occurring in a specific population in a given time period; thymoma is an uncommon tumor linked with myasthenia gravis and other autoimmune diseases" [http://medical-dictionary.thefreedictionary.com/thymoma, http://www.cancer.gov/cancertopics/pdq/treatment/thymoma/patient/page1#_139]
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Allelic Composition: Atmtm1Led/Atmtm1Led
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0014178 increased brain apoptosis "increase in the number of cells of the brain undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Atmtm2Pmc/Atmtm2Pmc,Pnkptm1.1Pmc/Pnkptm1.1Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000751 Rpa1 / Q8VEE4 / Replication protein A 70 kDa DNA-binding subunit / P27694* / replication protein A1*  / reaction / complex
 ENSMUSG00000003099 Ppp5c / Q60676 / Serine/threonine-protein phosphatase 5 / P53041* / protein phosphatase 5 catalytic subunit*  / reaction
 ENSMUSG00000002814 Top3a / O70157 / topoisomerase (DNA) III alpha / Q13472* / DNA topoisomerase III alpha*  / complex / reaction
 ENSMUSG00000002221 Paxip1 / Q6NZQ4 / PAX-interacting protein 1 / Q6ZW49*  / reaction / complex
 ENSMUSG00000017146 Brca1 / P48754 / Breast cancer type 1 susceptibility protein homolog / P38398* / BRCA1, DNA repair associated*  / complex / reaction
 ENSMUSG00000020380 Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*  / complex / reaction
 ENSMUSG00000014074 Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*  / reaction / complex
 ENSMUSG00000028886 Eya3 / P97480 / Eyes absent homolog 3 / Q99504* / EYA transcriptional coactivator and phosphatase 3*  / reaction
 ENSMUSG00000012483 Rpa3 / Q9CQ71 / Replication protein A 14 kDa subunit / P35244* / replication protein A3*  / reaction / complex
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / complex / reaction
 ENSMUSG00000024201 Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*  / reaction / complex
 ENSMUSG00000026196 Bard1 / O70445 / BRCA1-associated RING domain protein 1 / Q99728* / BRCA1 associated RING domain 1*  / complex / reaction
 ENSMUSG00000028224 Nbn / Q9R207 / Nibrin / O60934*  / complex / reaction
 ENSMUSG00000035367 Rmi1 / Q9D4G9 / RecQ-mediated genome instability protein 1 / Q9H9A7* / RecQ mediated genome instability 1*  / complex / reaction
 ENSMUSG00000031583 Wrn / O09053 / Werner syndrome RecQ like helicase / Q14191*  / complex / reaction
 ENSMUSG00000032409 Atr / ATR serine/threonine kinase / Q13535*  / complex / reaction
 ENSMUSG00000039748 Exo1 / Q9QZ11 / Exonuclease 1 / Q9UQ84*  / complex / reaction
 ENSMUSG00000031928 Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*  / complex / reaction
 ENSMUSG00000037991 Rmi2 / Q3UPE3 / RecQ-mediated genome instability protein 2 / Q96E14* / RecQ mediated genome instability 2*  / complex / reaction
 ENSMUSG00000041238 Rbbp8 / Q80YR6 / retinoblastoma binding protein 8, endonuclease / Q99708* / RB binding protein 8, endonuclease*  / complex / reaction
 ENSMUSG00000035234 Q8BPZ8 / Abraxas1 / BRCA1 A complex subunit / Q6UWZ7* / abraxas 1, BRCA1 A complex subunit*  / reaction / complex
 ENSMUSG00000026648 Q8K4J0 / Dclre1c / Protein artemis / Q96SD1* / DNA cross-link repair 1C*  / reaction / complex
 ENSMUSG00000049932 H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*  / complex / reaction
 ENSMUSG00000034329 Brip1 / Q5SXJ3 / Fanconi anemia group J protein homolog / Q9BX63* / BRCA1 interacting protein C-terminal helicase 1*  / complex / reaction
 ENSMUSG00000025646 Atrip / Q8BMG1 / ATR-interacting protein / Q8WXE1*  / complex / reaction
 ENSMUSG00000033326 Kdm4a / Q8BW72 / Lysine-specific demethylase 4A / O75164* / AL451062.3* / lysine demethylase 4A*  / reaction / complex
 ENSMUSG00000057406 Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*  / complex / reaction
 ENSMUSG00000029521 Chek2 / Q9Z265 / Serine/threonine-protein kinase Chk2 / O96017* / checkpoint kinase 2*  / complex / reaction
 ENSMUSG00000030528 Blm / O88700 / Bloom syndrome protein homolog / P54132* / Bloom syndrome RecQ like helicase*  / complex / reaction
 ENSMUSG00000036875 Dna2 / Q6ZQJ5 / DNA replication ATP-dependent helicase/nuclease DNA2 DNA replication nuclease DNA2 DNA replication ATP-dependent helicase DNA2 / P51530* / DNA replication helicase/nuclease 2*  / complex / reaction
 ENSMUSG00000061607 Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*  / reaction / complex
 ENSMUSG00000028884 Rpa2 / replication protein A2 / P15927*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / complex / reaction
 ENSMUSG00000036202 Rif1 / Q6PR54 / Telomere-associated protein RIF1 / Q5UIP0* / replication timing regulatory factor 1*  / complex / reaction
 ENSMUSG00000024926 Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*  / complex
 ENSMUSG00000037032 Apbb1 / Q9QXJ1 / Amyloid-beta A4 protein-binding family B member 1 / O00213* / amyloid beta precursor protein binding family B member 1*  / complex / reaction
 ENSMUSG00000025358 Cdk2 / P97377 / Cyclin-dependent kinase 2 / P24941*  / complex / reaction
 ENSMUSG00000030451 Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*  / complex / reaction
 ENSMUSG00000040782 Cop1 / Q9R1A8 / COP1, E3 ubiquitin ligase / Q8NHY2*  / reaction
 ENSMUSG00000028630 Dyrk2 / Q5U4C9 / Dual specificity tyrosine-phosphorylation-regulated kinase 2 / Q92630*  / reaction
 ENSMUSG00000025932 Eya1 / P97767 / Eyes absent homolog 1 / Q99502* / EYA transcriptional coactivator and phosphatase 1*  / reaction
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000006288 Ttc5 / Q99LG4 / tetratricopeptide repeat domain 5 / Q8N0Z6*  / reaction
 ENSMUSG00000004934 Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*  / complex / reaction
 ENSMUSG00000025878 Uimc1 / ubiquitin interaction motif containing 1 / Q96RL1*  / reaction / complex
 ENSMUSG00000054387 Mdm4 / O35618 / transformed mouse 3T3 cell double minute 4 / O15151* / MDM4, p53 regulator*  / reaction
 ENSMUSG00000022674 Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*  / complex
 ENSMUSG00000026842 Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000090083 Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000017897 Eya2 / O08575 / Eyes absent homolog 2 / O00167* / EYA transcriptional coactivator and phosphatase 2*  / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / complex
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / reaction
 ENSMUSG00000025507 Pidd1 / Q9ERV7 / p53-induced death domain-containing protein 1 / Q9HB75* / p53-induced death domain protein 1*  / reaction
 ENSMUSG00000033712 Ccar2 / Q8VDP4 / Cell cycle and apoptosis regulator protein 2 / Q8N163* / cell cycle and apoptosis regulator 2*  / reaction
 ENSMUSG00000098374 Gm28043 / RNF8* / O76064* / ring finger protein 8*  / reaction / complex
 ENSMUSG00000032113 Chek1 / O35280 / Serine/threonine-protein kinase Chk1 / O14757* / checkpoint kinase 1*  / reaction
 ENSMUSG00000043909 P70399 / Trp53bp1 / TP53-binding protein 1 / Q12888* / TP53BP1* / tumor protein p53 binding protein 1*  / reaction / complex
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
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