Manteia

ENSMUSG00000033326

Mus musculus

Features

Gene ID:	ENSMUSG00000033326

Biological name :	Kdm4a

Synonyms :	Kdm4a / Lysine-specific demethylase 4A / Q8BW72

Possible biological names infered from orthology :	AL451062.3 / lysine demethylase 4A / O75164

Species:	Mus musculus

Chr. number:	4
Strand:	-1
Band:	D2.1
Gene start:	118136957
Gene end:	118180043

Corresponding Affymetrix probe sets:	10515590 (MoGene1.0st) 1435340_at (Mouse Genome 430 2.0 Array) 1446699_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000062910 Ensembl peptide - ENSMUSP00000095524 Ensembl peptide - ENSMUSP00000102011 Ensembl peptide - ENSMUSP00000102014 NCBI entrez gene - 230674 See in Manteia. MGI - MGI:2446210 RefSeq - XM_006503011 RefSeq - NM_001161823 RefSeq - NM_172382 RefSeq - XM_006503010 RefSeq Peptide - NP_759014 RefSeq Peptide - NP_001155295 swissprot - Q8BW72 swissprot - A2A8L9 Ensembl - ENSMUSG00000033326

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
kdm4aa	ENSDARG00000018782	Danio rerio
kdm4ab	ENSDARG00000019103	Danio rerio
	ENSGALG00000041647	Gallus gallus
	ENSGALG00000010074	Gallus gallus
AL451062.3	ENSG00000284989	Homo sapiens
KDM4A	ENSG00000066135	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Kdm4b / Q91VY5 / Lysine-specific demethylase 4B / O94953* / lysine demethylase 4B*	ENSMUSG00000024201	50
Kdm4c / Q8VCD7 / Mus musculus lysine (K)-specific demethylase 4C (Kdm4c), transcript variant 3, mRNA. / Q9H3R0* / lysine demethylase 4C*	ENSMUSG00000028397	50
Kdm4d / Q3U2K5 / Lysine-specific demethylase 4D / KDM4E* / KDM4F* / B2RXH2* / Q6B0I6* / lysine demethylase 4E* / lysine demethylase 4D* / lysine demethylase 4F*	ENSMUSG00000053914	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR001965	Zinc finger, PHD-type
IPR002999	Tudor domain
IPR003347	JmjC domain
IPR003349	JmjN domain
IPR011011	Zinc finger, FYVE/PHD-type
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR034732	Extended PHD (ePHD) domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006325	chromatin organization	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0010507	negative regulation of autophagy	ISO
biological_process	GO:0010628	positive regulation of gene expression	IEA
biological_process	GO:0010629	negative regulation of gene expression	ISO
biological_process	GO:0014898	cardiac muscle hypertrophy in response to stress	IMP
biological_process	GO:0016577	histone demethylation	ISO
biological_process	GO:0031667	response to nutrient levels	IEA
biological_process	GO:0033169	histone H3-K9 demethylation	ISO
biological_process	GO:0045666	positive regulation of neuron differentiation	IEA
biological_process	GO:0045892	negative regulation of transcription, DNA-templated	ISO
biological_process	GO:0048712	negative regulation of astrocyte differentiation	IEA
biological_process	GO:0055114	oxidation-reduction process	IEA
biological_process	GO:0060548	negative regulation of cell death	IEA
biological_process	GO:0070544	histone H3-K36 demethylation	ISO
biological_process	GO:1900113	negative regulation of histone H3-K9 trimethylation	IDA
cellular_component	GO:0001650	fibrillar center	ISO
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005721	pericentric heterochromatin	IDA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	ISO
molecular_function	GO:0008270	zinc ion binding	ISO
molecular_function	GO:0016491	oxidoreductase activity	IEA
molecular_function	GO:0031625	ubiquitin protein ligase binding	ISO
molecular_function	GO:0032452	histone demethylase activity	IDA
molecular_function	GO:0032454	histone demethylase activity (H3-K9 specific)	ISO
molecular_function	GO:0035064	methylated histone binding	ISS
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0051213	dioxygenase activity	IEA
molecular_function	GO:0051864	histone demethylase activity (H3-K36 specific)	ISO

Pathways (from Reactome)

Pathway description

HDMs demethylate histones

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002834	decreased heart weight	"less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ghr^tm1.1Dlr/Ghr^tm1.1Dlr,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * DBA
MP:0003921	abnormal left ventricle morphology	"structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ghr^tm1.1Dlr/Ghr^tm1.1Dlr,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * DBA
MP:0004486	decreased response of heart to induced stress	"decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1.1Dlr/Ghr^tm1.1Dlr,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * DBA
MP:0004565	small myocardial fiber	"decreased size of the cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ghr^tm1.1Dlr/Ghr^tm1.1Dlr,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * DBA
MP:0005599	increased cardiac muscle contractility	"greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Ghr^tm1.1Dlr/Ghr^tm1.1Dlr,Tg(Ins2-cre)25Mgn/0 Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * DBA

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000020380	Rad50 / RAD50 double strand break repair protein / Q92878* / AC116366.3*	/ complex / reaction
ENSMUSG00000014074	Q80XJ2 / Rnf168 / E3 ubiquitin-protein ligase RNF168 / Q8IYW5* / ring finger protein 168*	/ reaction / complex
ENSMUSG00000028224	Nbn / Q9R207 / Nibrin / O60934*	/ complex / reaction
ENSMUSG00000031928	Mre11a / Q61216 / Double-strand break repair protein MRE11 / MRE11* / P49959* / MRE11 homolog, double strand break repair nuclease*	/ complex / reaction
ENSMUSG00000049932	H2afx / P27661 / Histone H2AX / P16104* / H2A histone family member X*	/ complex / reaction
ENSMUSG00000060981	P62806 / Hist1h4h / Histone H4	/ reaction / complex
ENSMUSG00000024926	Kat5 / Q8CHK4 / Histone acetyltransferase KAT5 / Q92993* / lysine acetyltransferase 5*	/ reaction / complex
ENSMUSG00000015120	Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*	/ reaction
ENSMUSG00000090083	Rnf8 / Q8VC56 / E3 ubiquitin-protein ligase RNF8 / O76064* / ring finger protein 8*	/ complex / reaction
ENSMUSG00000034218	Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*	/ complex / reaction
ENSMUSG00000030451	Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*	/ reaction / complex
ENSMUSG00000026021	Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*	/ complex / reaction
ENSMUSG00000098374	Gm28043 / RNF8* / O76064* / ring finger protein 8*	/ reaction / complex
ENSMUSG00000004934	Pias4 / Q9JM05 / protein inhibitor of activated STAT 4 / Q8N2W9*	/ reaction / complex
ENSMUSG00000061607	Mdc1 / Q14676* / mediator of DNA damage checkpoint 1*	/ complex / reaction
ENSMUSG00000057406	Nsd2 / Q8BVE8 / Histone-lysine N-methyltransferase NSD2 / O96028* / nuclear receptor binding SET domain protein 2*	/ complex / reaction
ENSMUSG00000022674	Q9D2M8 / Ube2v2 / ubiquitin-conjugating enzyme E2 variant 2 / Q15819* / ubiquitin conjugating enzyme E2 V2*	/ complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr