ENSG00000066135


Homo sapiens

Features
Gene ID: ENSG00000066135
  
Biological name :KDM4A
  
Synonyms : KDM4A / lysine demethylase 4A / O75164
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.2
Gene start: 43650158
Gene end: 43705515
  
Corresponding Affymetrix probe sets: 203204_s_at (Human Genome U133 Plus 2.0 Array)   203205_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361473
Ensembl peptide - ENSP00000493741
Ensembl peptide - ENSP00000496362
NCBI entrez gene - 9682     See in Manteia.
OMIM - 609764
RefSeq - XM_017002912
RefSeq - NM_014663
RefSeq - XM_005271355
RefSeq - XM_005271356
RefSeq - XM_005271354
RefSeq Peptide - NP_055478
swissprot - O75164
Ensembl - ENSG00000066135
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm4aaENSDARG00000018782Danio rerio
 kdm4abENSDARG00000019103Danio rerio
 ENSGALG00000041647Gallus gallus
 ENSGALG00000010074Gallus gallus
 Kdm4aENSMUSG00000033326Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KDM4C / Q9H3R0 / lysine demethylase 4CENSG0000010707752
KDM4B / O94953 / lysine demethylase 4BENSG0000012766351
KDM4F / lysine demethylase 4FENSG0000025585524
KDM4D / Q6B0I6 / lysine demethylase 4DENSG0000018628024
KDM4E / B2RXH2 / lysine demethylase 4EENSG0000023526823
AL451062.3ENSG0000028498920


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR002999  Tudor domain
 IPR003347  JmjC domain
 IPR003349  JmjN domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR034732  Extended PHD (ePHD) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016577 histone demethylation IDA
 biological_processGO:0033169 histone H3-K9 demethylation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070544 histone H3-K36 demethylation IDA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0032452 histone demethylase activity TAS
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) IMP
 molecular_functionGO:0035064 methylated histone binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) IDA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163961 Q8IYW5 / RNF168 / ring finger protein 168  / reaction / complex
 ENSG00000104320 NBN / nibrin / O60934  / complex / reaction
 ENSG00000169139 Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2  / reaction / complex
 ENSG00000113522 RAD50 / Q92878 / RAD50 double strand break repair protein  / reaction / complex
 ENSG00000172977 KAT5 / Q92993 / lysine acetyltransferase 5  / reaction / complex
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction / complex
 ENSG00000020922 MRE11 / P49959 / MRE11 homolog, double strand break repair nuclease  / complex / reaction
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction / complex
 ENSG00000188486 H2AFX / P16104 / H2A histone family member X  / complex / reaction
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex
 ENSG00000109685 NSD2 / O96028 / nuclear receptor binding SET domain protein 2  / complex / reaction
 ENSG00000105229 PIAS4 / Q8N2W9 / protein inhibitor of activated STAT 4  / complex / reaction
 ENSG00000128731 HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2  / complex / reaction
 ENSG00000112130 RNF8 / O76064 / ring finger protein 8  / complex / reaction
 ENSG00000137337 MDC1 / Q14676 / mediator of DNA damage checkpoint 1  / complex / reaction
 ENSG00000168148 Q16695 / HIST3H3 / histone cluster 3 H3  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction






 

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