ENSG00000107077


Homo sapiens

Features
Gene ID: ENSG00000107077
  
Biological name :KDM4C
  
Synonyms : KDM4C / lysine demethylase 4C / Q9H3R0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p24.1
Gene start: 6720863
Gene end: 7175648
  
Corresponding Affymetrix probe sets: 1556493_a_at (Human Genome U133 Plus 2.0 Array)   209984_at (Human Genome U133 Plus 2.0 Array)   214861_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404756
Ensembl peptide - ENSP00000400127
Ensembl peptide - ENSP00000405739
Ensembl peptide - ENSP00000445427
Ensembl peptide - ENSP00000440656
Ensembl peptide - ENSP00000370707
Ensembl peptide - ENSP00000370710
Ensembl peptide - ENSP00000383990
NCBI entrez gene - 23081     See in Manteia.
OMIM - 605469
RefSeq - XM_017014506
RefSeq - XM_011517811
RefSeq - XM_011517812
RefSeq - XM_011517816
RefSeq - XM_017014498
RefSeq - XM_017014499
RefSeq - XM_017014500
RefSeq - XM_017014501
RefSeq - XM_017014502
RefSeq - XM_017014503
RefSeq - XM_017014504
RefSeq - XM_017014505
RefSeq - NM_001146695
RefSeq - NM_001146696
RefSeq - NM_001304339
RefSeq - NM_001304340
RefSeq - NM_001304341
RefSeq - NM_015061
RefSeq - XM_006716741
RefSeq Peptide - NP_001140168
RefSeq Peptide - NP_001291268
RefSeq Peptide - NP_001291269
RefSeq Peptide - NP_001291270
RefSeq Peptide - NP_055876
RefSeq Peptide - NP_001140167
swissprot - B0QZ60
swissprot - F8WCN1
swissprot - C9J879
swissprot - Q9H3R0
swissprot - A0A0A0MSR6
Ensembl - ENSG00000107077
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kdm4cENSDARG00000061504Danio rerio
 KDM4CENSGALG00000020557Gallus gallus
 Kdm4cENSMUSG00000028397Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KDM4B / O94953 / lysine demethylase 4BENSG0000012766354
KDM4A / O75164 / lysine demethylase 4AENSG0000006613552
KDM4F / lysine demethylase 4FENSG0000025585524
KDM4D / Q6B0I6 / lysine demethylase 4DENSG0000018628024
KDM4E / B2RXH2 / lysine demethylase 4EENSG0000023526823
AL451062.3ENSG0000028498915


Protein motifs (from Interpro)
Interpro ID Name
 IPR001965  Zinc finger, PHD-type
 IPR002999  Tudor domain
 IPR003347  JmjC domain
 IPR003349  JmjN domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR034732  Extended PHD (ePHD) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001825 blastocyst formation IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0033169 histone H3-K9 demethylation IMP
 biological_processGO:0045666 positive regulation of neuron differentiation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070544 histone H3-K36 demethylation IDA
 biological_processGO:1900113 negative regulation of histone H3-K9 trimethylation IEA
 biological_processGO:2000036 regulation of stem cell population maintenance IEA
 biological_processGO:2000736 regulation of stem cell differentiation IEA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005721 pericentric heterochromatin IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0032452 histone demethylase activity TAS
 molecular_functionGO:0032454 histone demethylase activity (H3-K9 specific) IMP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050681 androgen receptor binding IPI
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0051864 histone demethylase activity (H3-K36 specific) IDA


Pathways (from Reactome)
Pathway description
HDMs demethylate histones
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000123143 PKN1 / Q16512 / protein kinase N1  / complex / reaction
 ENSG00000169083 AR / P10275 / androgen receptor  / reaction / complex
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction / complex
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction / complex






 

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