ENSG00000123143


Homo sapiens

Features
Gene ID: ENSG00000123143
  
Biological name :PKN1
  
Synonyms : PKN1 / protein kinase N1 / Q16512
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.12
Gene start: 14433053
Gene end: 14471867
  
Corresponding Affymetrix probe sets: 202161_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468497
Ensembl peptide - ENSP00000466819
Ensembl peptide - ENSP00000467422
Ensembl peptide - ENSP00000242783
Ensembl peptide - ENSP00000343325
Ensembl peptide - ENSP00000465842
Ensembl peptide - ENSP00000465867
Ensembl peptide - ENSP00000466367
NCBI entrez gene - 5585     See in Manteia.
OMIM - 601032
RefSeq - XM_011528128
RefSeq - NM_002741
RefSeq - NM_213560
RefSeq Peptide - NP_002732
RefSeq Peptide - NP_998725
swissprot - K7ES10
swissprot - Q16512
swissprot - K7EKY9
swissprot - K7EL10
swissprot - K7EN76
swissprot - K7EM57
swissprot - K7EPK3
Ensembl - ENSG00000123143
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pkn1aENSDARG00000060184Danio rerio
 pkn1bENSDARG00000062748Danio rerio
 Pkn1ENSMUSG00000057672Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PKN2 / Q16513 / protein kinase N2ENSG0000006524361
PKN3 / Q6P5Z2 / protein kinase N3ENSG0000016044749
AL355916.3ENSG000002589897


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011072  HR1 rho-binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR035892  C2 domain superfamily
 IPR036274  HR1 repeat superfamily
 IPR037313  Serine/threonine-protein kinase N, first HR1 domain
 IPR037317  Serine/threonine-protein kinase N1, second HR1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IEA
 biological_processGO:0001783 B cell apoptotic process IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0002634 regulation of germinal center formation IEA
 biological_processGO:0002637 regulation of immunoglobulin production IEA
 biological_processGO:0003014 renal system process IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006972 hyperosmotic response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007257 activation of JUN kinase activity TAS
 biological_processGO:0010631 epithelial cell migration IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030889 negative regulation of B cell proliferation IEA
 biological_processGO:0035407 histone H3-T11 phosphorylation IDA
 biological_processGO:0048536 spleen development IEA
 biological_processGO:2000145 regulation of cell motility IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017049 GTP-Rho binding IDA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IMP
 molecular_functionGO:0035402 histone kinase activity (H3-T11 specific) IDA
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0042826 histone deacetylase binding IDA
 molecular_functionGO:0048365 Rac GTPase binding IDA
 molecular_functionGO:0050681 androgen receptor binding IDA


Pathways (from Reactome)
Pathway description
RHO GTPases activate PKNs
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction / complex
 ENSG00000140396 NCOA2 / Q15596 / nuclear receptor coactivator 2  / complex / reaction
 ENSG00000169083 AR / P10275 / androgen receptor  / reaction / complex
 ENSG00000167641 Q96A00 / PPP1R14A / protein phosphatase 1 regulatory inhibitor subunit 14A  / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction / complex
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction / complex
 ENSG00000140992 PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1  / complex / reaction
 ENSG00000158402 CDC25C / P30307 / cell division cycle 25C  / reaction / complex
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / complex / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / complex / reaction
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / complex / reaction
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / reaction / complex
 ENSG00000004487 KDM1A / O60341 / lysine demethylase 1A  / reaction / complex
 ENSG00000107077 KDM4C / Q9H3R0 / lysine demethylase 4C  / reaction / complex






 

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