ENSG00000155366


Homo sapiens

Features
Gene ID: ENSG00000155366
  
Biological name :RHOC
  
Synonyms : P08134 / ras homolog family member C / RHOC
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p13.2
Gene start: 112701106
Gene end: 112707434
  
Corresponding Affymetrix probe sets: 200885_at (Human Genome U133 Plus 2.0 Array)   235742_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399424
Ensembl peptide - ENSP00000431392
Ensembl peptide - ENSP00000436240
Ensembl peptide - ENSP00000434877
Ensembl peptide - ENSP00000434310
Ensembl peptide - ENSP00000432209
Ensembl peptide - ENSP00000285735
Ensembl peptide - ENSP00000345236
Ensembl peptide - ENSP00000358646
Ensembl peptide - ENSP00000358647
Ensembl peptide - ENSP00000358650
Ensembl peptide - ENSP00000358651
Ensembl peptide - ENSP00000358652
Ensembl peptide - ENSP00000358656
Ensembl peptide - ENSP00000390823
Ensembl peptide - ENSP00000395791
NCBI entrez gene - 389     See in Manteia.
OMIM - 165380
RefSeq - NM_001042678
RefSeq - NM_001042679
RefSeq - NM_175744
RefSeq Peptide - NP_786886
RefSeq Peptide - NP_001036143
RefSeq Peptide - NP_001036144
swissprot - Q5JR06
swissprot - Q5JR07
swissprot - E9PQH6
swissprot - Q5JR08
swissprot - E9PN11
swissprot - E9PLA2
swissprot - A0A024R0I3
swissprot - P08134
swissprot - Q5JR05
Ensembl - ENSG00000155366
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhocaENSDARG00000021309Danio rerio
 rhocbENSDARG00000018328Danio rerio
 RHOCENSGALG00000001569Gallus gallus
 RhocENSMUSG00000002233Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RHOA / P61586 / ras homolog family member AENSG0000006756092
RHOB / P62745 / ras homolog family member BENSG0000014387884
AL603832.3ENSG0000027181055
RHOD / O00212 / ras homolog family member DENSG0000017315650
RHOF / Q9HBH0 / ras homolog family member F, filopodia associatedENSG0000013972549
RND3 / P61587 / Rho family GTPase 3ENSG0000011596349
RND2 / P52198 / Rho family GTPase 2ENSG0000010883047
RND1 / Q92730 / Rho family GTPase 1ENSG0000017260243


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0032464 positive regulation of protein homooligomerization ISS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP
 biological_processGO:0043297 apical junction assembly IDA
 biological_processGO:0044319 wound healing, spreading of cells ISS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0060193 positive regulation of lipase activity IDA
 biological_processGO:1902766 skeletal muscle satellite cell migration ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0032420 stereocilium ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity HMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases Activate Formins
RHO GTPases Activate Rhotekin and Rhophilins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114993 RTKN / Q9BST9 / rhotekin  / reaction / complex
 ENSG00000122966 CIT / O14578 / citron rho-interacting serine/threonine kinase  / reaction / complex
 ENSG00000164050 O43157 / PLXNB1 / plexin B1  / reaction
 ENSG00000132535 DLG4 / P78352 / discs large MAGUK scaffold protein 4  / reaction / complex
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / reaction
 ENSG00000172602 RND1 / Q92730 / Rho family GTPase 1  / reaction
 ENSG00000133392 MYH11 / P35749 / myosin heavy chain 11  / reaction
 ENSG00000140992 PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1  / reaction / complex
 ENSG00000067900 ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1  / complex / reaction
 ENSG00000134318 ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2  / complex / reaction
 ENSG00000213639 P62140 / PPP1CB / protein phosphatase 1 catalytic subunit beta  / reaction
 ENSG00000118680 MYL12B / O14950 / myosin light chain 12B  / reaction
 ENSG00000123143 PKN1 / Q16512 / protein kinase N1  / reaction / complex
 ENSG00000106683 LIMK1 / P53667 / LIM domain kinase 1  / reaction
 ENSG00000101335 MYL9 / P24844 / myosin light chain 9  / reaction
 ENSG00000118193 KIF14 / Q15058 / kinesin family member 14  / complex / reaction
 ENSG00000092841 MYL6 / P60660 / myosin light chain 6  / reaction
 ENSG00000058272 O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12A  / reaction
 ENSG00000065243 PKN2 / Q16513 / protein kinase N2  / complex / reaction
 ENSG00000184009 ACTG1 / P63261 / actin gamma 1  / reaction / complex
 ENSG00000075624 ACTB / P60709 / actin beta  / reaction / complex
 ENSG00000133026 MYH10 / P35580 / myosin heavy chain 10  / reaction
 ENSG00000105357 MYH14 / Q7Z406 / myosin heavy chain 14  / reaction
 ENSG00000077157 O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12B  / reaction
 ENSG00000100345 MYH9 / P35579 / myosin heavy chain 9  / reaction
 ENSG00000161791 FMNL3 / Q8IVF7 / formin like 3  / complex / reaction
 ENSG00000157827 FMNL2 / Q96PY5 / formin like 2  / complex / reaction
 ENSG00000187764 Q92854 / SEMA4D / semaphorin 4D  / reaction
 ENSG00000132694 O15085 / ARHGEF11 / Rho guanine nucleotide exchange factor 11  / reaction
 ENSG00000196914 Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12  / reaction
 ENSG00000198901 PRC1 / O43663 / protein regulator of cytokinesis 1  / complex / reaction






 

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