ENSG00000187764


Homo sapiens

Features
Gene ID: ENSG00000187764
  
Biological name :SEMA4D
  
Synonyms : Q92854 / SEMA4D / semaphorin 4D
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q22.2
Gene start: 89360787
Gene end: 89498130
  
Corresponding Affymetrix probe sets: 203528_at (Human Genome U133 Plus 2.0 Array)   228891_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000411981
Ensembl peptide - ENSP00000405652
Ensembl peptide - ENSP00000413352
Ensembl peptide - ENSP00000446394
Ensembl peptide - ENSP00000438389
Ensembl peptide - ENSP00000416747
Ensembl peptide - ENSP00000416523
Ensembl peptide - ENSP00000344923
Ensembl peptide - ENSP00000348822
Ensembl peptide - ENSP00000388768
Ensembl peptide - ENSP00000390754
Ensembl peptide - ENSP00000391733
Ensembl peptide - ENSP00000395222
Ensembl peptide - ENSP00000399948
Ensembl peptide - ENSP00000405102
NCBI entrez gene - 10507     See in Manteia.
OMIM - 601866
RefSeq - XM_017014199
RefSeq - XM_011518131
RefSeq - XM_011518133
RefSeq - XM_011518134
RefSeq - XM_017014193
RefSeq - XM_017014194
RefSeq - XM_017014195
RefSeq - XM_017014196
RefSeq - XM_017014197
RefSeq - XM_017014198
RefSeq - NM_001142287
RefSeq - NM_006378
RefSeq - XM_005251654
RefSeq - XM_011518123
RefSeq - XM_011518124
RefSeq - XM_011518125
RefSeq - XM_011518127
RefSeq - XM_011518128
RefSeq - XM_011518129
RefSeq - XM_011518130
RefSeq Peptide - NP_001135759
RefSeq Peptide - NP_006369
swissprot - C9JFP1
swissprot - C9JD54
swissprot - E9PFD9
swissprot - Q92854
swissprot - A0A0C4DG45
swissprot - F5H044
swissprot - C9JYS7
Ensembl - ENSG00000187764
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SEMA4DENSDARG00000067801Danio rerio
 SEMA4DENSGALG00000010697Gallus gallus
 O09126ENSMUSG00000021451Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SEMA4B / semaphorin 4BENSG0000018503333
Q9C0C4 / SEMA4C / semaphorin 4CENSG0000016875833
Q9NTN9 / SEMA4G / semaphorin 4GENSG0000009553931
Q9H3S1 / SEMA4A / semaphorin 4AENSG0000019618930
Q14563 / SEMA3A / semaphorin 3AENSG0000007521327
O95754 / SEMA4F / ssemaphorin 4FENSG0000013562227
Q13214 / SEMA3B / semaphorin 3BENSG0000001217127
O95025 / SEMA3D / semaphorin 3DENSG0000015399326
Q9NS98 / SEMA3G / semaphorin 3GENSG0000001031926
Q13275 / SEMA3F / semaphorin 3FENSG0000000161726
Q99985 / SEMA3C / semaphorin 3CENSG0000007522325
O15041 / SEMA3E / semaphorin 3EENSG0000017038125


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR027231  Semaphorin
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036352  Sema domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007162 negative regulation of cell adhesion IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0010693 negative regulation of alkaline phosphatase activity IMP
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0031344 regulation of cell projection organization IMP
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043547 positive regulation of GTPase activity ISS
 biological_processGO:0043931 ossification involved in bone maturation IMP
 biological_processGO:0045668 negative regulation of osteoblast differentiation ISS
 biological_processGO:0048672 positive regulation of collateral sprouting IMP
 biological_processGO:0048814 regulation of dendrite morphogenesis IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0050919 negative chemotaxis IBA
 biological_processGO:0070486 leukocyte aggregation IMP
 biological_processGO:0071526 semaphorin-plexin signaling pathway IMP
 biological_processGO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis ISS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IMP
 molecular_functionGO:0005102 signaling receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030215 semaphorin receptor binding ISS


Pathways (from Reactome)
Pathway description
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse
Other semaphorin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164050 O43157 / PLXNB1 / plexin B1  / complex / reaction
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / reaction / complex
 ENSG00000172602 RND1 / Q92730 / Rho family GTPase 1  / reaction / complex
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex / reaction
 ENSG00000132694 O15085 / ARHGEF11 / Rho guanine nucleotide exchange factor 11  / reaction / complex
 ENSG00000187764 Q92854 / SEMA4D / semaphorin 4D  / complex
 ENSG00000137101 CD72 / P21854 / CD72 molecule  / complex / reaction
 ENSG00000196914 Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction / complex
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000160007 Q9NRY4 / ARHGAP35 / Rho GTPase activating protein 35  / reaction / complex
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / reaction
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / reaction






 

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