ENSG00000196914


Homo sapiens

Features
Gene ID: ENSG00000196914
  
Biological name :ARHGEF12
  
Synonyms : ARHGEF12 / Q9NZN5 / Rho guanine nucleotide exchange factor 12
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q23.3
Gene start: 120336914
Gene end: 120489936
  
Corresponding Affymetrix probe sets: 1559833_at (Human Genome U133 Plus 2.0 Array)   1566093_at (Human Genome U133 Plus 2.0 Array)   1570471_at (Human Genome U133 Plus 2.0 Array)   201333_s_at (Human Genome U133 Plus 2.0 Array)   201334_s_at (Human Genome U133 Plus 2.0 Array)   201335_s_at (Human Genome U133 Plus 2.0 Array)   210741_at (Human Genome U133 Plus 2.0 Array)   233620_at (Human Genome U133 Plus 2.0 Array)   233621_s_at (Human Genome U133 Plus 2.0 Array)   234129_at (Human Genome U133 Plus 2.0 Array)   234541_s_at (Human Genome U133 Plus 2.0 Array)   234542_at (Human Genome U133 Plus 2.0 Array)   234544_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000432984
Ensembl peptide - ENSP00000349056
Ensembl peptide - ENSP00000380942
NCBI entrez gene - 23365     See in Manteia.
OMIM - 604763
RefSeq - XM_017017422
RefSeq - NM_001198665
RefSeq - NM_001301084
RefSeq - NM_015313
RefSeq - XM_006718805
RefSeq - XM_011542720
RefSeq - XM_017017420
RefSeq - XM_017017421
RefSeq Peptide - NP_001185594
RefSeq Peptide - NP_001288013
RefSeq Peptide - NP_056128
swissprot - E9PMR6
swissprot - Q9NZN5
Ensembl - ENSG00000196914
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef12aENSDARG00000030532Danio rerio
 arhgef12bENSDARG00000100913Danio rerio
 ARHGEF12ENSGALG00000006663Gallus gallus
 Q8R4H2ENSMUSG00000059495Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O15085 / ARHGEF11 / Rho guanine nucleotide exchange factor 11ENSG0000013269433
Q92888 / ARHGEF1 / Rho guanine nucleotide exchange factor 1ENSG0000007692823
AKAP13 / Q12802 / A-kinase anchoring protein 13ENSG0000017077618
Q8N1W1 / ARHGEF28 / Rho guanine nucleotide exchange factor 28ENSG0000021494416
Q6ZSZ5 / ARHGEF18 / Rho/Rac guanine nucleotide exchange factor 18ENSG0000010488012
AC008878.3ENSG0000026886112
Q92974 / ARHGEF2 / Rho/Rac guanine nucleotide exchange factor 2ENSG0000011658411
NET1 / Q7Z628 / neuroepithelial cell transforming 1ENSG000001738488
Q9NR81 / ARHGEF3 / Rho guanine nucleotide exchange factor 3ENSG000001639477


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015212  Regulator of G protein signalling-like domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036034  PDZ superfamily
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164050 O43157 / PLXNB1 / plexin B1  / reaction / complex
 ENSG00000141736 ERBB2 / P04626 / erb-b2 receptor tyrosine kinase 2  / complex / reaction
 ENSG00000172602 RND1 / Q92730 / Rho family GTPase 1  / reaction / complex
 ENSG00000187764 Q92854 / SEMA4D / semaphorin 4D  / reaction / complex
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / reaction
 ENSG00000120063 GNA13 / Q14344 / G protein subunit alpha 13  / complex / reaction
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / reaction
 ENSG00000146535 GNA12 / Q03113 / G protein subunit alpha 12  / complex / reaction






 

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