ENSG00000163947


Homo sapiens

Features
Gene ID: ENSG00000163947
  
Biological name :ARHGEF3
  
Synonyms : ARHGEF3 / Q9NR81 / Rho guanine nucleotide exchange factor 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p14.3
Gene start: 56727418
Gene end: 57079329
  
Corresponding Affymetrix probe sets: 218501_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417986
Ensembl peptide - ENSP00000417810
Ensembl peptide - ENSP00000418469
Ensembl peptide - ENSP00000420633
Ensembl peptide - ENSP00000420420
Ensembl peptide - ENSP00000420402
Ensembl peptide - ENSP00000418984
Ensembl peptide - ENSP00000418826
Ensembl peptide - ENSP00000296315
Ensembl peptide - ENSP00000341071
Ensembl peptide - ENSP00000410922
Ensembl peptide - ENSP00000417087
NCBI entrez gene - 50650     See in Manteia.
OMIM - 612115
RefSeq - XM_017006506
RefSeq - NM_001128615
RefSeq - NM_001128616
RefSeq - NM_001289698
RefSeq - NM_019555
RefSeq - XM_005265186
RefSeq - XM_005265187
RefSeq - XM_011533764
RefSeq - XM_011533765
RefSeq - XM_011533766
RefSeq - XM_011533767
RefSeq - XM_017006502
RefSeq - XM_017006503
RefSeq - XM_017006504
RefSeq - XM_017006505
RefSeq Peptide - NP_001276627
RefSeq Peptide - NP_062455
RefSeq Peptide - NP_001122087
RefSeq Peptide - NP_001122088
swissprot - C9J5K8
swissprot - F8WC29
swissprot - F8WDB7
swissprot - E9PG37
swissprot - Q9NR81
swissprot - C9J586
swissprot - H7C4P0
swissprot - E7EU49
swissprot - C9JNF2
swissprot - C9J609
Ensembl - ENSG00000163947
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef3ENSDARG00000013834Danio rerio
 ARHGEF3ENSGALG00000005481Gallus gallus
 Q91X46ENSMUSG00000021895Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NET1 / Q7Z628 / neuroepithelial cell transforming 1ENSG0000017384853
Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12ENSG0000019691420
Q8N1W1 / ARHGEF28 / Rho guanine nucleotide exchange factor 28ENSG0000021494419
AKAP13 / Q12802 / A-kinase anchoring protein 13ENSG0000017077619
O15085 / ARHGEF11 / Rho guanine nucleotide exchange factor 11ENSG0000013269418
AC008878.3ENSG0000026886116
Q92888 / ARHGEF1 / Rho guanine nucleotide exchange factor 1ENSG0000007692816
Q6ZSZ5 / ARHGEF18 / Rho/Rac guanine nucleotide exchange factor 18ENSG0000010488016
Q92974 / ARHGEF2 / Rho/Rac guanine nucleotide exchange factor 2ENSG0000011658415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007266 Rho protein signal transduction TAS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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