ENSG00000173848


Homo sapiens

Features
Gene ID: ENSG00000173848
  
Biological name :NET1
  
Synonyms : NET1 / neuroepithelial cell transforming 1 / Q7Z628
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: p15.1
Gene start: 5412551
Gene end: 5458463
  
Corresponding Affymetrix probe sets: 201829_at (Human Genome U133 Plus 2.0 Array)   201830_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000347134
Ensembl peptide - ENSP00000369717
Ensembl peptide - ENSP00000403101
NCBI entrez gene - 10276     See in Manteia.
OMIM - 606450
RefSeq - NM_005863
RefSeq - NM_001047160
RefSeq Peptide - NP_001040625
RefSeq Peptide - NP_005854
swissprot - Q5SQI5
swissprot - Q5SQI6
swissprot - Q5SQI7
swissprot - Q7Z628
Ensembl - ENSG00000173848
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 net1ENSDARG00000032765Danio rerio
 NET1ENSGALG00000008437Gallus gallus
 Net1ENSMUSG00000021215Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NR81 / ARHGEF3 / Rho guanine nucleotide exchange factor 3ENSG0000016394750
Q9NZN5 / ARHGEF12 / Rho guanine nucleotide exchange factor 12ENSG0000019691422
O15085 / ARHGEF11 / Rho guanine nucleotide exchange factor 11ENSG0000013269420
AKAP13 / Q12802 / A-kinase anchoring protein 13ENSG0000017077618
Q8N1W1 / ARHGEF28 / Rho guanine nucleotide exchange factor 28ENSG0000021494418
Q92888 / ARHGEF1 / Rho guanine nucleotide exchange factor 1ENSG0000007692817
Q6ZSZ5 / ARHGEF18 / Rho/Rac guanine nucleotide exchange factor 18ENSG0000010488015
AC008878.3ENSG0000026886115
Q92974 / ARHGEF2 / Rho/Rac guanine nucleotide exchange factor 2ENSG0000011658412


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth NAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0051451 myoblast migration IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IDA
 biological_processGO:0071479 cellular response to ionizing radiation IDA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017049 GTP-Rho binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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