ENSMUSG00000021215


Mus musculus

Features
Gene ID: ENSMUSG00000021215
  
Biological name :Net1
  
Synonyms : Net1 / neuroepithelial cell transforming gene 1 / Q9Z206
  
Possible biological names infered from orthology : neuroepithelial cell transforming 1 / Q7Z628
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A1
Gene start: 3882018
Gene end: 3918220
  
Corresponding Affymetrix probe sets: 10407420 (MoGene1.0st)   1421321_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152173
Ensembl peptide - ENSMUSP00000152333
Ensembl peptide - ENSMUSP00000089464
Ensembl peptide - ENSMUSP00000097529
NCBI entrez gene - 56349     See in Manteia.
MGI - MGI:1927138
RefSeq - NM_001047159
RefSeq - NM_019671
RefSeq Peptide - NP_001040624
RefSeq Peptide - NP_062645
swissprot - Q9Z206
swissprot - A0A1Y7VJ80
swissprot - Q3USZ7
swissprot - A0A1Y7VKV6
Ensembl - ENSMUSG00000021215
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 net1ENSDARG00000032765Danio rerio
 NET1ENSGALG00000008437Gallus gallus
 NET1ENSG00000173848Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91X46 / Arhgef3 / Rho guanine nucleotide exchange factor 3 / Q9NR81*ENSMUSG0000002189550
Q8R4H2 / Arhgef12 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q9NZN5* / Rho guanine nucleotide exchange factor 12*ENSMUSG0000005949521
Akap13 / E9Q394 / A-kinase anchor protein 13 / Q12802* / A-kinase anchoring protein 13*ENSMUSG0000006640619
Arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*ENSMUSG0000004197719
Arhgef28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*ENSMUSG0000002166217
Q61210 / Arhgef1 / Rho guanine nucleotide exchange factor 1 / Q92888*ENSMUSG0000004094016
Q60875 / Arhgef2 / Rho guanine nucleotide exchange factor 2 / Q92974* / Rho/Rac guanine nucleotide exchange factor 2*ENSMUSG0000002805914
Q6P9R4 / Arhgef18 / Rho guanine nucleotide exchange factor 18 / Q6ZSZ5* / AC008878.3* / Rho/Rac guanine nucleotide exchange factor 18*ENSMUSG0000000456814


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051451 myoblast migration IGI
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071479 cellular response to ionizing radiation IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017049 GTP-Rho binding IDA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0008904 abnormal mammary fat pad morphology "any structural anomaly of the encapsulated adipose tissue associated with the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

 MP:0013784 abnormal mammary gland bud elongation "any anomaly in the process in which a mammary bud grows along its axis; in mouse embryos, the distal end of the mammary bud begins to elongate into the underlying dermal mesenchyme to form a mammary cord (sprout) by E15.5" [MGI:Anna, PMID:25467960]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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