ENSMUSG00000004568


Mus musculus

Features
Gene ID: ENSMUSG00000004568
  
Biological name :Arhgef18
  
Synonyms : Arhgef18 / Q6P9R4 / Rho guanine nucleotide exchange factor 18
  
Possible biological names infered from orthology : AC008878.3 / Q6ZSZ5 / Rho/Rac guanine nucleotide exchange factor 18
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 3393006
Gene end: 3456601
  
Corresponding Affymetrix probe sets: 10569733 (MoGene1.0st)   1418553_at (Mouse Genome 430 2.0 Array)   1440700_a_at (Mouse Genome 430 2.0 Array)   1444650_at (Mouse Genome 430 2.0 Array)   1457219_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004684
Ensembl peptide - ENSMUSP00000118410
NCBI entrez gene - 102098     See in Manteia.
MGI - MGI:2142567
RefSeq - XM_017312501
RefSeq - NM_133962
RefSeq - XM_006508681
RefSeq - XM_006508682
RefSeq Peptide - NP_598723
swissprot - D3YWI3
swissprot - Q6P9R4
Ensembl - ENSMUSG00000004568
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef18aENSDARG00000011157Danio rerio
 arhgef18bENSDARG00000042308Danio rerio
 ENSGALG00000003572Gallus gallus
 AC008878.3ENSG00000268861Homo sapiens
 Q6ZSZ5ENSG00000104880Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arhgef28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*ENSMUSG0000002166239
Akap13 / E9Q394 / A-kinase anchor protein 13 / Q12802* / A-kinase anchoring protein 13*ENSMUSG0000006640636
Q60875 / Arhgef2 / Rho guanine nucleotide exchange factor 2 / Q92974* / Rho/Rac guanine nucleotide exchange factor 2*ENSMUSG0000002805927
Q8R4H2 / Arhgef12 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q9NZN5* / Rho guanine nucleotide exchange factor 12*ENSMUSG0000005949516
Arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*ENSMUSG0000004197716
Q61210 / Arhgef1 / Rho guanine nucleotide exchange factor 1 / Q92888*ENSMUSG0000004094014
Q91X46 / Arhgef3 / Rho guanine nucleotide exchange factor 3 / Q9NR81*ENSMUSG000000218959
Net1 / Q9Z206 / neuroepithelial cell transforming gene 1 / Q7Z628* / neuroepithelial cell transforming 1*ENSMUSG000000212158


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction ISO
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0030036 actin cytoskeleton organization ISO
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0045177 apical part of cell ISO
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gnl3Gt(S4-4B1)Sor/Gnl3Gt(S4-4B1)Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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