ENSMUSG00000021895


Mus musculus

Features
Gene ID: ENSMUSG00000021895
  
Biological name :Arhgef3
  
Synonyms : Arhgef3 / Q91X46 / Rho guanine nucleotide exchange factor 3
  
Possible biological names infered from orthology : Q9NR81
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: A3
Gene start: 27114899
Gene end: 27403911
  
Corresponding Affymetrix probe sets: 10413419 (MoGene1.0st)   1424250_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046486
Ensembl peptide - ENSMUSP00000153124
Ensembl peptide - ENSMUSP00000153396
NCBI entrez gene - 71704     See in Manteia.
MGI - MGI:1918954
RefSeq - XM_006519580
RefSeq - NM_001289686
RefSeq - NM_001289687
RefSeq - NM_001289688
RefSeq - NM_027871
RefSeq - XM_006519574
RefSeq - XM_006519575
RefSeq - XM_006519576
RefSeq - XM_006519579
RefSeq Peptide - NP_001276615
RefSeq Peptide - NP_001276616
RefSeq Peptide - NP_001276617
RefSeq Peptide - NP_082147
swissprot - Q91X46
swissprot - A0A286YDE6
Ensembl - ENSMUSG00000021895
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef3ENSDARG00000013834Danio rerio
 ARHGEF3ENSGALG00000005481Gallus gallus
 Q9NR81ENSG00000163947Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Net1 / Q9Z206 / neuroepithelial cell transforming gene 1 / Q7Z628* / neuroepithelial cell transforming 1*ENSMUSG0000002121556
Q8R4H2 / Arhgef12 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q9NZN5* / Rho guanine nucleotide exchange factor 12*ENSMUSG0000005949520
Akap13 / E9Q394 / A-kinase anchor protein 13 / Q12802* / A-kinase anchoring protein 13*ENSMUSG0000006640619
Arhgef28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*ENSMUSG0000002166219
Arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*ENSMUSG0000004197719
Q61210 / Arhgef1 / Rho guanine nucleotide exchange factor 1 / Q92888*ENSMUSG0000004094017
Q6P9R4 / Arhgef18 / Rho guanine nucleotide exchange factor 18 / Q6ZSZ5* / AC008878.3* / Rho/Rac guanine nucleotide exchange factor 18*ENSMUSG0000000456816
Q60875 / Arhgef2 / Rho guanine nucleotide exchange factor 2 / Q92974* / Rho/Rac guanine nucleotide exchange factor 2*ENSMUSG0000002805915


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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