ENSMUSG00000066406


Mus musculus

Features
Gene ID: ENSMUSG00000066406
  
Biological name :Akap13
  
Synonyms : Akap13 / A-kinase anchor protein 13 / E9Q394
  
Possible biological names infered from orthology : A-kinase anchoring protein 13 / Q12802
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: D1
Gene start: 75455534
Gene end: 75754609
  
Corresponding Affymetrix probe sets: 10554166 (MoGene1.0st)   1430185_at (Mouse Genome 430 2.0 Array)   1430404_at (Mouse Genome 430 2.0 Array)   1430445_at (Mouse Genome 430 2.0 Array)   1433722_at (Mouse Genome 430 2.0 Array)   1439254_at (Mouse Genome 430 2.0 Array)   1440392_at (Mouse Genome 430 2.0 Array)   1443923_at (Mouse Genome 430 2.0 Array)   1445311_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129784
Ensembl peptide - ENSMUSP00000146503
Ensembl peptide - ENSMUSP00000146401
Ensembl peptide - ENSMUSP00000147237
Ensembl peptide - ENSMUSP00000146990
Ensembl peptide - ENSMUSP00000146779
NCBI entrez gene - 75547     See in Manteia.
MGI - MGI:2676556
RefSeq - XM_017312363
RefSeq - XM_006541254
RefSeq - XM_006541255
RefSeq - XM_006541256
RefSeq - XM_006541257
RefSeq - XM_006541258
RefSeq - XM_006541259
RefSeq - XM_006541260
RefSeq - NM_029332
RefSeq - XM_006541250
RefSeq - XM_006541251
RefSeq - XM_006541252
RefSeq - XM_006541253
RefSeq Peptide - NP_083608
swissprot - A0A140LJJ5
swissprot - A0A140LIX0
swissprot - E9Q394
swissprot - A0A140LHQ3
swissprot - A0A140LHG3
swissprot - A0A140LID7
Ensembl - ENSMUSG00000066406
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AKAP13ENSDARG00000079994Danio rerio
 si:dkey-172h23.2ENSDARG00000023868Danio rerio
 AKAP13ENSGALG00000006840Gallus gallus
 AKAP13ENSG00000170776Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arhgef28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*ENSMUSG0000002166219
Q60875 / Arhgef2 / Rho guanine nucleotide exchange factor 2 / Q92974* / Rho/Rac guanine nucleotide exchange factor 2*ENSMUSG0000002805914
Q6P9R4 / Arhgef18 / Rho guanine nucleotide exchange factor 18 / Q6ZSZ5* / AC008878.3* / Rho/Rac guanine nucleotide exchange factor 18*ENSMUSG0000000456813
Q8R4H2 / Arhgef12 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q9NZN5* / Rho guanine nucleotide exchange factor 12*ENSMUSG000000594959
Arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*ENSMUSG000000419779
Q61210 / Arhgef1 / Rho guanine nucleotide exchange factor 1 / Q92888*ENSMUSG000000409406
Net1 / Q9Z206 / neuroepithelial cell transforming gene 1 / Q7Z628* / neuroepithelial cell transforming 1*ENSMUSG000000212154
Q91X46 / Arhgef3 / Rho guanine nucleotide exchange factor 3 / Q9NR81*ENSMUSG000000218954


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011993  PH-like domain superfamily
 IPR028852  A-kinase anchor protein 13
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0010611 regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035025 positive regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0051168 nuclear export IEA
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 biological_processGO:0060297 regulation of sarcomere organization IMP
 biological_processGO:0060348 bone development IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071875 adrenergic receptor signaling pathway IEA
 biological_processGO:0086023 adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process IMP
 biological_processGO:1900169 regulation of glucocorticoid mediated signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IDA
 cellular_componentGO:0005938 cell cortex ISS
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004691 cAMP-dependent protein kinase activity IEA
 molecular_functionGO:0005078 MAP-kinase scaffold activity IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0017048 Rho GTPase binding IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051018 protein kinase A binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Omptm1(cre)Jae/Omp+
Genetic Background: involves: 129S1/Sv

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Omptm1(cre)Jae/Omp+
Genetic Background: involves: 129S1/Sv

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Pgrmc1tm1.1Jjp/Pgrmc1tm1.1Jjp,Omptm1(cre)Jae/Omp+
Genetic Background: involves: 129S1/Sv

 MP:0006341 small first branchial arch "reduced size of the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0009333 abnormal splenocyte physiology "any functional anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0009922 increased transitional stage T1 B cell number "greater number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
Show

Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
Show

Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0010503 myocardial trabeculae hypoplasia "underdevelopment or reduced size of the supporting bundles of muscular fibers lining the walls of the heart, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
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Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

 MP:0012723 abnormal nuchal region morphology "any structural anomaly of the posterior region of the neck, including the suboccipital region" [MGI:anna]
Show

Allelic Composition: Mcph1tm1.1Zqw/Mcph1tm1.1Zqw
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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