ENSMUSG00000028059


Mus musculus

Features
Gene ID: ENSMUSG00000028059
  
Biological name :Arhgef2
  
Synonyms : Arhgef2 / Q60875 / Rho guanine nucleotide exchange factor 2
  
Possible biological names infered from orthology : Q92974 / Rho/Rac guanine nucleotide exchange factor 2
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 88605966
Gene end: 88648052
  
Corresponding Affymetrix probe sets: 10493267 (MoGene1.0st)   1421042_at (Mouse Genome 430 2.0 Array)   1421043_s_at (Mouse Genome 430 2.0 Array)   1427646_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135808
Ensembl peptide - ENSMUSP00000029694
Ensembl peptide - ENSMUSP00000103134
Ensembl peptide - ENSMUSP00000127843
Ensembl peptide - ENSMUSP00000134766
Ensembl peptide - ENSMUSP00000134834
Ensembl peptide - ENSMUSP00000134840
Ensembl peptide - ENSMUSP00000134843
Ensembl peptide - ENSMUSP00000134859
Ensembl peptide - ENSMUSP00000135044
Ensembl peptide - ENSMUSP00000135131
Ensembl peptide - ENSMUSP00000135168
Ensembl peptide - ENSMUSP00000135177
Ensembl peptide - ENSMUSP00000135397
Ensembl peptide - ENSMUSP00000135428
Ensembl peptide - ENSMUSP00000135612
Ensembl peptide - ENSMUSP00000135771
NCBI entrez gene - 16800     See in Manteia.
MGI - MGI:103264
RefSeq - XM_011240027
RefSeq - NM_001198911
RefSeq - NM_001198912
RefSeq - NM_001198913
RefSeq - NM_008487
RefSeq - XM_006501058
RefSeq - XM_006501059
RefSeq - XM_006501060
RefSeq - XM_006501061
RefSeq - XM_006501064
RefSeq - XM_006501065
RefSeq - XM_006501066
RefSeq - XM_006501067
RefSeq Peptide - NP_032513
RefSeq Peptide - NP_001185840
RefSeq Peptide - NP_001185841
RefSeq Peptide - NP_001185842
swissprot - H3BJ40
swissprot - H3BJ45
swissprot - H3BJ48
swissprot - H3BJ59
swissprot - H3BJM4
swissprot - H3BJU7
swissprot - H3BJX8
swissprot - H3BKH9
swissprot - H3BL15
swissprot - H3BLF9
swissprot - Q60875
swissprot - H3BIX8
swissprot - H3BLJ1
Ensembl - ENSMUSG00000028059
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef1aENSDARG00000040380Danio rerio
 arhgef2ENSDARG00000075819Danio rerio
 Q92974ENSG00000116584Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Akap13 / E9Q394 / A-kinase anchor protein 13 / Q12802* / A-kinase anchoring protein 13*ENSMUSG0000006640640
Arhgef28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*ENSMUSG0000002166232
Q6P9R4 / Arhgef18 / Rho guanine nucleotide exchange factor 18 / Q6ZSZ5* / AC008878.3* / Rho/Rac guanine nucleotide exchange factor 18*ENSMUSG0000000456828
Q8R4H2 / Arhgef12 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q9NZN5* / Rho guanine nucleotide exchange factor 12*ENSMUSG0000005949517
Arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*ENSMUSG0000004197717
Q61210 / Arhgef1 / Rho guanine nucleotide exchange factor 1 / Q92888*ENSMUSG0000004094015
Net1 / Q9Z206 / neuroepithelial cell transforming gene 1 / Q7Z628* / neuroepithelial cell transforming 1*ENSMUSG000000212158
Q91X46 / Arhgef3 / Rho guanine nucleotide exchange factor 3 / Q9NR81*ENSMUSG000000218958


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000132 establishment of mitotic spindle orientation IMP
 biological_processGO:0000902 cell morphogenesis ISS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007015 actin filament organization ISS
 biological_processGO:0007026 negative regulation of microtubule depolymerization ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production ISS
 biological_processGO:0032760 positive regulation of tumor necrosis factor production ISO
 biological_processGO:0035023 regulation of Rho protein signal transduction IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045666 positive regulation of neuron differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0050768 negative regulation of neurogenesis IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0055059 asymmetric neuroblast division IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071225 cellular response to muramyl dipeptide ISS
 biological_processGO:0071802 negative regulation of podosome assembly IMP
 biological_processGO:2001224 positive regulation of neuron migration IMP
 cellular_componentGO:0002102 podosome IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton ISO
 cellular_componentGO:0005874 microtubule ISO
 cellular_componentGO:0005923 bicellular tight junction IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031982 vesicle ISO
 cellular_componentGO:0032587 ruffle membrane ISS
 cellular_componentGO:0032991 protein-containing complex ISS
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043198 dendritic shaft IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding ISO
 molecular_functionGO:0017048 Rho GTPase binding ISS
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048365 Rac GTPase binding ISS


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Ros1tm1.1Char/Ros1tm1.1Char
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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